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Nitric Oxide Donors - 1st Edition - ISBN: 9780128092750, 9780128134597

Nitric Oxide Donors

1st Edition

Novel Biomedical Applications and Perspectives

Author: Amedea Seabra
Paperback ISBN: 9780128092750
eBook ISBN: 9780128134597
Imprint: Academic Press
Published Date: 17th March 2017
Page Count: 364
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Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges and innovations in the design of therapeutics nitric oxide donors with great impact in several aspects of human physiology and pathophysiology. Although considerable innovative progress has been achieved using Nitric Oxide donors in biomedical applications, certain drawbacks still need to be overcome to successfully translate these research innovations into clinical applications.

This book encompasses several topics on nitric oxide such as its sources and biological properties; its performance in the cardiovascular and neurologic systems, in the human skin and its application in the treatment of neglected diseases, neurodegenerative disorders, and cancer. Additionally, it covers its role in inflammation and immunity, penile erection function, photodynamic therapy, antimicrobial activities. It also discusses the future of nitric oxide donors in combination with other therapeutic drugs, in implantable sensors, and nitric oxide releasing hydrogels and medical devices for topical applications.

The book is a valuable source for researchers on different areas of biomedical field who are interested in the improvements that these molecules can make in the treatment of several conditions.

Key Features

  • Provides background information about biology and chemistry of nitric oxide
  • Discusses the state-of-the-art in the design of nitric oxide releasing nanomaterials for biomedical applications
  • Covers the usage of nitric oxide donors in the treatment of several conditions, such as cancer, human skin, cardiovascular system, and immunity
  • Discusses the future of nitric oxide donors and their FDA approval


Graduate students synthetic biologists, medical doctors, physicians, biochemists, pharmacists

Table of Contents

Chapter 1. Nitric Oxide Derivative Ruthenium Compounds as NO-Based Chemotherapeutic and Phototherapeutic Agents

  • Abstract
  • Introduction
  • Nitrosyl Ruthenium Complexes as NO Delivery Agents
  • Ruthenium-Nitrogen Oxide Derivatives as NO Sources
  • Nitrosyl Ruthenium Complexes as NO Delivery Agent by Reduction Process
  • Photo-Nitric Oxide Release Promoted by Ruthenium Complexes
  • Image: A Powerful Tool to Elucidate Cytotoxicity Mechanisms of No Donor Agents Based on Ruthenium Complexes
  • Conclusion
  • References

Chapter 2. Nitric Oxide Donors for Treating Neglected Diseases

  • Abstract
  • Neglected Diseases
  • Why Using NO Donors to Treat Neglected Diseases?
  • Malaria
  • Leishmaniasis
  • Trypanosomiasis
  • Schistosomiasis
  • Tuberculosis
  • Dengue Fever
  • Blastocystis Hominis Infection
  • NO Donors and Lymphatic Filariasis
  • NO Donors and Other Neglected Diseases
  • Mechanisms of Action of NO Against Pathogens That Cause Neglected Diseases
  • Final Remarks: Challenges and Perspectives
  • Acknowledgments
  • References

Chapter 3. Nitric Oxide-Donating Devices for Topical Applications

  • Abstract
  • Introduction
  • NO’s Role in the Body
  • Topical Applicators
  • Conclusion
  • References

Chapter 4. Nitric Oxide Donors and Therapeutic Applications in Cancer

  • Abstract
  • Introduction
  • Cellular Actions of NO
  • NSAIDs Protect Against Cancer, Proof of Principle
  • Side Effects Associated with NSAID Use
  • Nitric Oxide-Releasing NSAIDs (NO-NSAIDs) and the Rationale for Their Development
  • Structural Features of Nitrate NO-NSAIDs
  • NO-Releasing Coxibs
  • Cancer Prevention with NO-NSAIDs
  • Biological Actions of the Spacer in NO-ASA
  • Diazeniumdiolate-Based NO-Releasing Compounds
  • RRx-001 an Aerospace Compound for Cancer Treatment
  • Concluding Remarks and Future Directions
  • Acknowledgment
  • References

Chapter 5. Nitric Oxide Donors and Penile Erectile Function

  • Abstract
  • Introduction
  • Nitric Oxide Synthase (NOS) Isoforms
  • The Role of NO in Erectile Physiology
  • ED and Its Prevalence
  • NO Donors
  • NO Donors for Erectile Function
  • Sodium Nitrite (NaNO2)
  • S-nitroacetylpenicillamine
  • Sodium Nitroprusside
  • Organic Nitrates
  • Sydnonimines
  • Oximes
  • Spermine NONOate
  • S-nitrosothiols
  • Nitrosamines
  • PDE-5 Inhibitors
  • sGC Stimulators and Activators
  • NO-Donating Statins
  • Conclusions and Perspectives
  • References

Chapter 6. Nitric Oxide Donors in Nerve Regeneration

  • Abstract
  • Introduction
  • NO in Neuroregeneration
  • Neuronal Growth and Synaptic Plasticity
  • Neuroprotectant
  • NO in Neurodegeneration
  • Alzheimer’s Disease
  • Parkinson’s Disease
  • Huntington’s Disease
  • Examples of NO Donors Evaluated for Nerve Regeneration
  • Locust Studies on NO-cGMP with NOC-18 and SNP
  • Goldfish Optic Nerve Regeneration Studied with NOR-2 and SNAP
  • Regenerating RGCs of Cats with Nipradilol
  • Reinnervation After Penile Nerve Crush Studies with SNP in Rats
  • Exogenous SNAC on Motor Functional Recovery in Rats
  • S-Nitrosoglutathione (GSNO) Effects After I/R injury in Rats
  • GSNO Influences Angiogenesis in Rats
  • Conclusion
  • In Memoriam: Vinod B. Damodaran
  • References

Chapter 7. Nitric Oxide Donors as Antimicrobial Agents

  • Abstract
  • Nitric Oxide
  • Biosynthesis of NO
  • NO Inactivation Chemistry
  • Biological Effects of NO
  • NO Regulation in Microbes
  • NO as an Antimicrobial and Antibiofilm Agent
  • NO Gas as an Antimicrobial Agent
  • NO Donors as Antimicrobials
  • Dual Action NO Donors as Antimicrobials
  • Conclusion
  • References

Chapter 8. Improving the Performance of Implantable Sensors with Nitric Oxide Release

  • Abstract
  • Introduction
  • Biological Response to Implanted Sensors
  • The Role NO Could Play
  • NO Donors and Generators Applied to Sensors
  • Conclusion and Future Directions
  • References

Chapter 9. Strategies to Deliver Nitric Oxide Donors to Control Biofilms of Clinical and Industrial Interest

  • Abstract
  • Introduction
  • Dual Function of NO: Antibacterial Agent and Genetic Regulator in Bacteria
  • NO Donor Platforms to Control Biofilm of Clinical Interest
  • Delivery of NO via Small Molecular Weight Donors
  • Conclusion
  • References

Chapter 10. Developing New Organic Nitrates for Treating Hypertension

  • Abstract
  • Introduction
  • Historical Perspective
  • Important Organic Nitrates Used in Clinic
  • Organic Nitrates and Arterial Hypertension
  • Nitrate Tolerance
  • New Insights on Drug Development
  • Acknowledgments
  • References

Chapter 11. Nitric Oxide Donors in Brain Inflammation

  • Abstract
  • Introduction
  • Role of Nitric Oxide in Brain Physiology
  • Neuroinflammation and NO in Damaged Brain
  • NO Donors as Neuroprotective Agents in Brain Inflammation
  • Concluding Remarks
  • References

Chapter 12. Synergistic Activities of Nitric Oxide and Various Drugs

  • Abstract
  • Introduction
  • Delivery of NOS
  • NO and Anticancer Drug Cotreatment
  • NO Anticancer Drug Hybrids
  • NO-Based Antibacterial and Biofilm Dispersal Agents
  • Synergic Effect of NO with Antibiotics
  • Conclusion
  • References

Chapter 13. Hydrogels for Topical Nitric Oxide Delivery

  • Abstract
  • Hydrogels with Dissolved Molecular NO Donors
  • Hydrogels with Covalently Attached NO Donors
  • Gels Based on Extemporaneous NO Release
  • Supramolecular NO-Releasing Hydrogels
  • Conclusion
  • References


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© Academic Press 2017
17th March 2017
Academic Press
Paperback ISBN:
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About the Author

Amedea Seabra

Amedea B. Seabra holds a diploma degree in Chemistry from University of São Paulo (USP). She finished her Ph.D. at Chemistry Institute, State University of Campinas (UNICAMP) in 2006. Thereafter, she worked as a Research Fellow at UNICAMP (2006–2008), and she took postdoctoral studies at the Chemistry and Biochemistry Department, Concordia University in Montreal, Canada (2008–2010).She is associated professor at Federal University of ABC (UFABC). Her present research is focused on the preparation, characterization and evaluation of the cytotoxicity of nitric oxide-releasing nanomaterials for biomedical and agricultural applications.

Affiliations and Expertise

Associate Professor, Federal University of ABC (UFABC)

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