Nitric Oxide (Donor/Induced) in Chemosensitization

Nitric Oxide (Donor/Induced) in Chemosensitization

1st Edition - June 12, 2017

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  • Editor: Benjamin Bonavida
  • Hardcover ISBN: 9780128164716
  • eBook ISBN: 9780128110218

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Nitric Oxide as a Chemosensitizing Agent, Volume One is the first book to describe several reviews by authoritative scientists and clinicians on novel findings in the reversal of drug resistant cancers by the combination treatment of Nitric Oxide and sub toxic concentrations of chemotherapeutic drugs that have been reported in both in vitro, in vivo and preclinical models. The book describes the various underlying chemical, molecular and genetic mechanisms by which NO and NO reactive species mediate the anti-cancer activity, thus reducing the threshold of drug resistance and enabling chemo therapeutic drugs to induce their cytotoxic activity and reversal of resistance. This book exposes scientists and clinicians to this highly beneficial topic for research investigations and pharmaceutical companies to new avenues for R&D. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use Nitric Oxide as a sensitizing agent for chemotherapy.

Key Features

  • Brings updated information as reviewed by experts in the field
  • Presents expert analysis and summary of reported and novel findings and potential translational application in cancer patients
  • Describes molecular mechanisms with new and helpful approaches that can be used in reader investigations


Cancer researchers; oncologists; pharmacists; graduate students in cancer studies

Table of Contents

  • 1. Nitric Oxide Mediated Chemosensitization: Gene Therapy Versus Exogenous Introduction of NO Donors
    2. Nitric Oxide Donors Sensitize Resistant Cancer Cells to Apoptosis Induced by Chemotherapy: Molecular Mechanisms of Sensitization
    3. RRx-001 Reset: Chemoresensitization Via NO-Mediated M1 Macrophage Repolarization
    4. Nitric Oxide and Nitric Oxide-Donors in Pre-Clinical Studies of Breast and Prostate Cancer
    5. Evaluation of the Impact of Nitric Oxide on Resistance to Platinum-Based Chemotherapeutics
    6. Nitric oxide and platinum derivatives-based regimens for cancer treatment: from preclinical studies to clinical trials
    7. NO-H2S Releasing Chimeras as a Multifaceted Approach to Cancer Therapy
    8. Nitric Oxide-based Anticancer Therapeutics: The New Technologies of The Nanoparticles
    9. Nitric Oxide in Rectal Cancer: from Mice to Patients
    10. Chemoprotective and Chemosensitizing Effects of Nitric oxide and Other Biologically Active Gases in Breast Cancer Chemotherapy: Potential Implications
    11. Role of Nitric Oxide in Cancer Stem Cell Regulation and Metastasis 
    12. Nitric Oxide Interacting with Glutathione Transferases 
    13. Application of MRI to Study the Role of Nitric Oxide in Cancer Therapy
    14. S-Nitrosothiol Metabolism In Cancer And Therapeutic Implications

Product details

  • No. of pages: 248
  • Language: English
  • Copyright: © Academic Press 2017
  • Published: June 12, 2017
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128164716
  • eBook ISBN: 9780128110218

About the Editor

Benjamin Bonavida

Benjamin Bonavida, PhD, has been involved in the field of immunology and cancer biology for several decades and has published extensively in the fields of cancer resistance, chemotherapy, immunotherapy, and various molecular approaches to circumvent the resistance of the cancer cells using sensitizing agents. Accordingly, he was the first to publish a book on tumor sensitization in 2008. More recently, Dr. Bonavida is the Series Editor of 3 series published by Elsevier/Academic Press (“Cancer Sensitizing Agents for Chemotherapy,” “Breaking Cancer Resistance to Therapeutic Antibodies,” and “Breaking Tolerance to Anti-Cancer Immunotherapy”) and several books have been published and many are in development. He has published extensively in the field of NK biology and cytotoxicity in the past, and many of these publications were in collaboration with the co-editor Dr. Anahid Jewett.

Affiliations and Expertise

Professor, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, USA

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