Nicotinic Acetylcholine Receptors in Health and Disease provides the latest information Nicotinic acetylcholine receptors (nAChRs), which are involved in numerous diseases, including Alzheimer’s, Parkinson’s, and schizophrenia, and are important potential translational targets for treatment of these diseases, as well as therapy for addiction. This book focuses on the roles and function of nAChRs inside and outside of the nervous system, with an emphasis on translational implications and future prospects for the treatment of numerous disorders. This greater understanding of the basic neurobiology and clinical roles of nAChRs provides important insights for future clinical treatments of many major disorders.
Describes the roles, expression and function of nicotinic receptors
Includes receptor involvement, both inside and outside the nervous system
Details nicotinic receptor involvement in Alzheimer’s, Parkinson’s, Cancer, Schizophrenia, and more
Emphasizes future treatment prospects of disorders via modulation of nAChR signaling
Undergraduate and graduate students in medicine, health sciences, and biological sciences, neuroscientists, clinicians, post-doctoral fellows, and researchers
Table of Contents
Introduction: Overview of nAChRs, will focus on neuronal receptors 1. nAChR Structure 2. Receptor Localization, Subtype Diversity, and Evolution 3. Ion Channel Function, and Biophysics
Associate Professor in the Department of Neuroscience at Ohio State University. Involved in undergraduate and graduate education for most of his career, he served on the Neuroscience Graduate Studies Program Graduate Studies Committee for many years and is currently on the Biomedical Sciences Graduate Programs Graduate Studies Committee (BSGP). He was involved in the development of the Neuroscience major at Ohio State and has taught a large undergraduate Neuroscience class for more than 10 years. Research activities in the Boyd laboratory emphasize a molecular biological analysis of neuronal nicotinic acetylcholine receptors (nAChRs) and were the first to clone the zebrafish neuronal nAChR genes and determine its expression pattern during development. The information derived from these studies is being used to develop zebrafish as a model for studying the role of nAChRs in normal development of the nervous system and the mechanisms by which nicotine perturbs this.