Nicotine Use in Mental Illness and Neurological Disorders, Volume 124

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• Preface
• Part 1: Introductory chapter
  • Chapter One: Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine
    • Abstract
    • 1 Introduction
    • 2 Nicotinic Receptor Structure
    • 3 Nicotinic Receptor Channel Gating
    • 4 Cationic Permeability of the Nicotinic Receptor Pore
    • 5 Nicotinic Receptor Response to Nicotine from Tobacco
    • 6 Conclusion
    • Acknowledgment
• Part 2: Schizophrenia
  • Chapter Two: The Role of Nicotine in Schizophrenia
    • Abstract
    • 1 Introduction
    • 2 Effects of Nicotine on Schizophrenia Endophenotypes and Symptom Domains
    • 3 Nicotinic Receptor Genes in Schizophrenia
    • 4 Development of Nicotinic Agents for the Treatment of Schizophrenia
    • 5 Conclusions
  • Chapter Three: Neuronal α7 Nicotinic Receptors as a Target for the Treatment of Schizophrenia
    • Abstract
    • 1 Introduction
    • 2 The α7 nAChRs
    • 3 The Heteromeric α7-Containing Receptors
    • 4 Localization of the α7 Receptors
    • 5 Allosteric Modulation
    • 6 The α7 Receptors in Brain Circuits
    • 7 α7 Receptors and Schizophrenia
    • 8 α7 and NMDA Receptor Interactions in Schizophrenia
    • 9 α7 Receptors as a Drug Target
    • 10 Effects of α7-Selective Compounds on Behavior
    • 11 Conclusions
  • Chapter Four: Role of the Neuregulin Signaling Pathway in Nicotine Dependence and Co-morbid Disorders
    • Abstract
    • 1 Introduction
    • 2 Known Mechanisms of Neuregulin–ErbB Signaling
    • 3 NRG3: Relevance in Smoking Behavior and Co-morbid Disorders
    • 4 ERBB4: Relevance in Smoking Behavior and Co-morbid Disorders
    • 5 Summary
  • Chapter Five: Effective Cessation Strategies for Smokers with Schizophrenia
    • Abstract
    • 1 Efficacy of Bupropion, as Monotherapy or in Combination with NRT
    • 2 Efficacy of Varenicline
    • 3 Duration of Treatment
    • 4 Behavioral Treatment
    • 5 Treatment Adherence
    • 6 Safety Issues
    • 7 Conclusion
• Part 3: Mood disorders
  • Chapter Six: Role of the Brain's Reward Circuitry in Depression: Transcriptional Mechanisms
    • Abstract
    • 1 Introduction
    • 2 The NAc Reward Circuit in Mood Regulation
    • 3 Transcriptional and Epigenetic Mechanisms in the NAc in Mood Regulation
    • 4 Future Directions
    • Acknowledgment
  • Chapter Seven: Nicotine Addiction and Psychiatric Disorders
    • Abstract
    • 1 Introduction
    • 2 Nicotine's Effects on ADHD
    • 3 Involvement of nAChRs in Anxiety and Anxiety Disorders
    • 4 Effects of Nicotine Dependence, Withdrawal, and nAChR Regulation on Depression
    • 5 Conclusion
    • Acknowledgment
  • Chapter Eight: The Role of Depression in the Uptake and Maintenance of Cigarette Smoking
    • Abstract
    • 1 The Smoking and Depression Problem
    • 2 Adolescent Smoking Uptake and Depression
    • 3 Smoking Cessation and Depression
    • 4 Targeting Positive Mood May Increase Smoking Cessation Treatment Effectiveness
    • 5 Individual Differences in Cessation Outcome and Treatment Effectiveness
    • 6 Conclusions
• Part 4: Parkinson's disease
  • Chapter Nine: Nicotine and Nicotinic Receptor Drugs: Potential for Parkinson's Disease and Drug-Induced Movement Disorders
    • Abstract
    • 1 Parkinson's Disease Overview
    • 2 Neuroprotection and Parkinson's Disease
    • 3 Nicotine and nAChR Drugs Do Not Improve Parkinsonian Motor Symptoms
    • 4 Nicotine and nAChR Drugs Reduce LIDs
    • 5 Nicotine and nAChR Drugs Reduce Antipsychotic-Induced Tardive Dyskinesias
    • 6 Beneficial Role of Nicotine and nAChR Drugs in Cognition, Depression, and Other Neuropsychiatric Disorders
    • 7 Concluding Remarks
    • Acknowledgment
• Part 5: Alzheimer's disease
  • Chapter Ten: Nicotinic Cholinergic Mechanisms in Alzheimer's Disease
    • Abstract
    • 1 Homomeric and Heteromeric α7-nAChRs
    • 2 Alterations of α7-nAChR Expressions in AD Animal Models and AD Patients
    • 3 Interaction of Amyloid Beta Peptides (Aβ) and α7-nAChRs
    • 4 Coincident Roles of α7-nAChRs in Aβ Toxicity
    • 5 Roles of α7-nAChRs in Neuronal Hyperexcitation in AD
    • 6 Coincident Roles of α7-nAChRs in AD Pathogenesis
    • 7 Conclusions
• Index
• Contents of Recent Volumes

Nicotine Use in Mental Illness and Neurological Disorders, a volume in the International Review of Neurobiology series, is a comprehensive overview of the state-of-the-art research into nicotine use in mental illness and neurological disorders. It reviews current knowledge and understanding, also provides a starting point for researchers and practitioners entering the field.

• Provides a broad coverage of subject matter
• Presents a comprehensive overview of the state-of-the-art research into nicotine use in mental illness and neurological disorders
• Ideal for researchers and practitioners, and those just entering the field

People working in basic neuroscience, neurology and psychiatry; medical doctors and care givers.