Nicotine Use in Mental Illness and Neurological Disorders

Nicotine Use in Mental Illness and Neurological Disorders

1st Edition - October 1, 2015

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  • Editor: Mariella De Biasi
  • Hardcover ISBN: 9780128015834
  • eBook ISBN: 9780128016268

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Description

Nicotine Use in Mental Illness and Neurological Disorders, a volume in the International Review of Neurobiology series, is a comprehensive overview of the state-of-the-art research into nicotine use in mental illness and neurological disorders. It reviews current knowledge and understanding, also provides a starting point for researchers and practitioners entering the field.

Key Features

  • Provides a broad coverage of subject matter
  • Presents a comprehensive overview of the state-of-the-art research into nicotine use in mental illness and neurological disorders
  • Ideal for researchers and practitioners, and those just entering the field

Readership

People working in basic neuroscience, neurology and psychiatry; medical doctors and care givers.

Table of Contents

    • Preface
    • Part 1: Introductory chapter
      • Chapter One: Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine
        • Abstract
        • 1 Introduction
        • 2 Nicotinic Receptor Structure
        • 3 Nicotinic Receptor Channel Gating
        • 4 Cationic Permeability of the Nicotinic Receptor Pore
        • 5 Nicotinic Receptor Response to Nicotine from Tobacco
        • 6 Conclusion
        • Acknowledgment
    • Part 2: Schizophrenia
      • Chapter Two: The Role of Nicotine in Schizophrenia
        • Abstract
        • 1 Introduction
        • 2 Effects of Nicotine on Schizophrenia Endophenotypes and Symptom Domains
        • 3 Nicotinic Receptor Genes in Schizophrenia
        • 4 Development of Nicotinic Agents for the Treatment of Schizophrenia
        • 5 Conclusions
      • Chapter Three: Neuronal α7 Nicotinic Receptors as a Target for the Treatment of Schizophrenia
        • Abstract
        • 1 Introduction
        • 2 The α7 nAChRs
        • 3 The Heteromeric α7-Containing Receptors
        • 4 Localization of the α7 Receptors
        • 5 Allosteric Modulation
        • 6 The α7 Receptors in Brain Circuits
        • 7 α7 Receptors and Schizophrenia
        • 8 α7 and NMDA Receptor Interactions in Schizophrenia
        • 9 α7 Receptors as a Drug Target
        • 10 Effects of α7-Selective Compounds on Behavior
        • 11 Conclusions
      • Chapter Four: Role of the Neuregulin Signaling Pathway in Nicotine Dependence and Co-morbid Disorders
        • Abstract
        • 1 Introduction
        • 2 Known Mechanisms of Neuregulin–ErbB Signaling
        • 3 NRG3: Relevance in Smoking Behavior and Co-morbid Disorders
        • 4 ERBB4: Relevance in Smoking Behavior and Co-morbid Disorders
        • 5 Summary
      • Chapter Five: Effective Cessation Strategies for Smokers with Schizophrenia
        • Abstract
        • 1 Efficacy of Bupropion, as Monotherapy or in Combination with NRT
        • 2 Efficacy of Varenicline
        • 3 Duration of Treatment
        • 4 Behavioral Treatment
        • 5 Treatment Adherence
        • 6 Safety Issues
        • 7 Conclusion
    • Part 3: Mood disorders
      • Chapter Six: Role of the Brain's Reward Circuitry in Depression: Transcriptional Mechanisms
        • Abstract
        • 1 Introduction
        • 2 The NAc Reward Circuit in Mood Regulation
        • 3 Transcriptional and Epigenetic Mechanisms in the NAc in Mood Regulation
        • 4 Future Directions
        • Acknowledgment
      • Chapter Seven: Nicotine Addiction and Psychiatric Disorders
        • Abstract
        • 1 Introduction
        • 2 Nicotine's Effects on ADHD
        • 3 Involvement of nAChRs in Anxiety and Anxiety Disorders
        • 4 Effects of Nicotine Dependence, Withdrawal, and nAChR Regulation on Depression
        • 5 Conclusion
        • Acknowledgment
      • Chapter Eight: The Role of Depression in the Uptake and Maintenance of Cigarette Smoking
        • Abstract
        • 1 The Smoking and Depression Problem
        • 2 Adolescent Smoking Uptake and Depression
        • 3 Smoking Cessation and Depression
        • 4 Targeting Positive Mood May Increase Smoking Cessation Treatment Effectiveness
        • 5 Individual Differences in Cessation Outcome and Treatment Effectiveness
        • 6 Conclusions
    • Part 4: Parkinson's disease
      • Chapter Nine: Nicotine and Nicotinic Receptor Drugs: Potential for Parkinson's Disease and Drug-Induced Movement Disorders
        • Abstract
        • 1 Parkinson's Disease Overview
        • 2 Neuroprotection and Parkinson's Disease
        • 3 Nicotine and nAChR Drugs Do Not Improve Parkinsonian Motor Symptoms
        • 4 Nicotine and nAChR Drugs Reduce LIDs
        • 5 Nicotine and nAChR Drugs Reduce Antipsychotic-Induced Tardive Dyskinesias
        • 6 Beneficial Role of Nicotine and nAChR Drugs in Cognition, Depression, and Other Neuropsychiatric Disorders
        • 7 Concluding Remarks
        • Acknowledgment
    • Part 5: Alzheimer's disease
      • Chapter Ten: Nicotinic Cholinergic Mechanisms in Alzheimer's Disease
        • Abstract
        • 1 Homomeric and Heteromeric α7-nAChRs
        • 2 Alterations of α7-nAChR Expressions in AD Animal Models and AD Patients
        • 3 Interaction of Amyloid Beta Peptides (Aβ) and α7-nAChRs
        • 4 Coincident Roles of α7-nAChRs in Aβ Toxicity
        • 5 Roles of α7-nAChRs in Neuronal Hyperexcitation in AD
        • 6 Coincident Roles of α7-nAChRs in AD Pathogenesis
        • 7 Conclusions
    • Index
    • Contents of Recent Volumes

Product details

  • No. of pages: 296
  • Language: English
  • Copyright: © Academic Press 2015
  • Published: October 1, 2015
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128015834
  • eBook ISBN: 9780128016268

About the Serial Volume Editor

Mariella De Biasi

Affiliations and Expertise

University of Pennsylvania, PA, USA

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