The book highlights different aspects of current understanding of neurotrophin-receptor signal transduction pathways, including the signaling endosome hypothesis. Findings on the synaptotrophic potential of NGF and related neurotrophins, neurotrophin involvement in neuronal stem cell biology, biological activity of the NGF precursor proNGF, and nociception- and antinociception-associated activity of NGF and/or BDNF are also presented and discussed.

Several chapters deal with the involvement of various neurotrophins in the control of different nonneuronal processes, such as immune, inflammatory and allergic reactions, tissue repair and wound healing. The findings showed that neurotrophins play important roles in the pathobiology of a surprising variety of seemingly unrelated non-neurological diseases, including bronchial asthma, rheumatoid arthritis, systemic sclerosis, hair growth disorders, psoriasis, corneal and skin ulcers, atherosclerosis, metabolic syndrome, crush syndrome, and Behçet's disease. There are also chapters on the involvement of NGF and related molecules in neurological diseases, including Huntington's disease, the multiple sclerosis-like model of experimental allergic encephalomyelitis, peripheral neuropathies, neuroblastoma, Parkinson's disease, Alzheimer's disease, and even motion sickness syndrome, also psychiatric disorders, including depression and schizophrenia. Finally, potential important therapeutic benefits are presented, for diabetic neuropathy, gastrointestinal dysmotility, CNS neurodegenerative disease, spinal cord injuries, cutaneous and corneal ulcers, as well as peripheral ischemic vasculopathy.

Table of Contents

List of contributors. Preface. Acknowledgements. I. Growth Factors and Cell Signaling. 1. Trafficking the NGF signal: implications for normal and degenerating neurons (J.-D. Delcroix, J. Valletta et al.). 2. The p75 neurotrophin receptor - multiple interactors and numerous functions (J.J. Gentry, P.A. Barker, B.D. Carter). 3. The role of neurotransmission and the Chopper domain in p75 neurotrophin receptor death signaling (E.J. Coulson, K. Reid et al.). 4. The role of NT-3 signaling in Merkel cell development (M. Sieber-Blum, V. Szeder, M. Grim). II. Growth Factors, Progenitor Cells and Cell Survival. 5. Stem cells and nervous tissue repair: from in vitro to in vivo (L. Calzà, M. Fernandez et al.). 6. Pathways of survival induced by NGF and extracellular ATP after grown factor deprivation (N. d'Ambrosi, B. Murra et al.). 7. ProNGF: a neurotrophic or an apoptotic molecule? (M. Fahnestock, G. Yu, M.D. Coughlin). 8. NGF deprivation-induced gene expression: after ten years, where do we stand? (R.S. Freeman, R.L. Burch et al.). 9. Neural stem and progenitor cells: choosing the right Shc (T. Cataudella, L. Conti, E. Cattaneo). III. Neurotrophins and CNS. 10. Acute and long-term synaptic modulation by neurotrophins (B. Lu). 11. Neurotrophic factors and psychiatric-like disorders: evidence in rodent models of schizophrenia and depression (F. Angelucci, A. Mathe). 12. Discovering novel phenotype-selective neurotrophic factors to treat neurodegenerative diseases (P.S. Petrova, A. Raibekas et al.). 13. Neurobehavioral coping to altered gravity: endogenous responses of neurotrophins (N. Francia, D. Santucci et al.). 14. Neurotrophic factors in Huntington's disease (J. Alberch, E. Pérez-Navarro, J.M. Canals). IV. Neurotrophins, PNS and Peripheral Tissues. 15. Neural crest development and neuroblastoma:


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© 2003
Elsevier Science
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About the editors

L. Aloe

Affiliations and Expertise

Istitute of Neurobiology and Molecular Medicine, National Research Council, Rome, Italy

L. Calza

Affiliations and Expertise

Department of Veterinary Morphophysiology and Animal Production DIMORFIPA, University of Bologna, Italy