New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System Part A

1st Edition, Volume 220 - October 6, 2015
Editors: Giacinto Bagetta, Carlo Nucci
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 4 - 6 3 5 6 6 - 2
eBook ISBN:
9 7 8 - 0 - 4 4 4 - 6 3 5 6 9 - 3

New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System is the latest volume from Progress in Brain Research focusing on new… Read more

New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System Part A

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New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System
is the latest volume from Progress in Brain Research focusing on new trends in basic and clinical research of glaucoma. This established international series examines major areas of basic and clinical research within neuroscience, as well as emerging subfields.

Preface
- Part A
Chapter 1: Retinal neurodegeneration in experimental glaucoma
- Abstract
- 1 Introduction
- 2 Methods
- 3 Results and Discussion
- 4 Concluding Remarks
- Acknowledgments
Chapter 2: Retinal ganglion cell apoptotic pathway in glaucoma: Initiating and downstream mechanisms
- Abstract
- 1 Introduction
- 2 The Initial Insult—BDNF and Neurotrophic Factor Deprivation
- 3 The MAP-Kinase Pathway in Glaucoma
- 4 JNK
- 5 p38
- 6 ERK
- 7 The BCL-2 Family
- 8 Caspases and Inhibitor of Apoptosis Proteins
- 9 Normal Tension Glaucoma
- 10 Limitations
- 11 Summary
Chapter 3: The contribution of the sclera and lamina cribrosa to the pathogenesis of glaucoma: Diagnostic and treatment implications
- Abstract
- 1 Introduction
- 2 The Interaction of PPS, Lamina Cribrosa, and IOP
- 3 Pathological Changes in the Sclera and ONH in Glaucoma
- 4 Role of Experimental Animal Models
- 5 Scleral and ONH Changes in Mouse Glaucoma
- 6 Remodeling of the ONH in Glaucoma
- 7 Connective Tissue-Based Therapies to Alter Glaucoma Damage
- 8 Conclusion
- Acknowledgments
Chapter 4: Autophagy dysregulation and the fate of retinal ganglion cells in glaucomatous optic neuropathy
- Abstract
- 1 Introduction
- 2 The Basics of Autophagy: Mechanisms, Regulation, and Functions
- 3 Autophagy and RGC Death in Glaucoma Models
- 4 Aging, Autophagy, and Glaucoma
- 5 Concluding Remarks
- Acknowledgment
Chapter 5: Advances in glaucoma genetics
- Abstract
- 1 Introduction
- 2 Familial Linkage Analysis: causative POAG Disease Genes
- 3 Association Studies for POAG
- 4 Perspective
Chapter 6: Oxidative stress and mitochondrial failure in the pathogenesis of glaucoma neurodegeneration
- Abstract
- 1 Introduction
- 2 Mitochondrial Involvement in Glaucoma Pathogenesis
- 3 Oxidative Stress in Eye Diseases
- 4 Antioxidants and Glaucoma. Improving Glaucoma Prognosis by Applying Targeted Neuroprotection
- 5 Final Remarks
Chapter 7: Macro- and microglial responses in the fellow eyes contralateral to glaucomatous eyes
- Abstract
- 1 Introduction
- 2 The Contralateral Eye is Involved in Some Experimental Glaucoma Models
- 3 RGC Damage After Axonal Injury: Optic-Nerve Crush and Optic-Nerve Section
- 4 RGC Damage After IOP Elevation
- 5 Mechanisms Responsible for Contralateral Eye Involvement
- Acknowledgments
Chapter 8: Retinal and optic nerve changes in glaucoma: From animal study to clinical implication
- Abstract
- 1 Introduction
- 2 Confocal Scanning Laser Tomography
- 3 Scanning Laser Polarimetry
- 4 Spectral Domain Optical Coherence Tomography
- 5 Adaptive Optics Confocal Scanning Laser Tomography
- 6 Summary
- Acknowledgments
Chapter 9: Lymphatic drainage from the eye: A new target for therapy
- Abstract
- 1 Introduction
- 2 Aqueous Humor Dynamics and IOP
- 3 The Role of Ocular Lymphatics in Aqueous Humor Drainage
- 4 Lymphatics: A Novel Treatment Target for Glaucoma
- 5 Key Challenges
- 6 Significance
- Acknowledgments
Chapter 10: Retinal ganglion cell dendrite pathology and synapse loss: Implications for glaucoma
- Abstract
- 1 Does Dendritic Pathology Contribute to Vision Loss in Glaucoma?
- 2 Morphological Diversity of RGC Dendrites: An Embarrassment of Riches
- 3 Axonal Injury Triggers Pathological Changes in RGC Dendrites
- 4 Mechanisms That Regulate Dendrite and Synapse Stability
- 5 Conclusions and Future Directions
- Acknowledgments
Chapter 11: MicroRNA target prediction in glaucoma
- Abstract
- 1 Introduction
- 2 Methods
- 3 Results
- 4 Discussion
Chapter 12: Stem cell approaches to glaucoma: from aqueous outflow modulation to retinal neuroprotection
- Abstract
- 1 Introduction
- 2 Stem Cells
- 3 Aqueous Outflow Modulation
- 4 Retinal Neuroprotection
- 5 RGC Replacement and Regeneration
- 6 Delivery Methods
- 7 Clinical Application and Translation
- 8 Conclusions
- Acknowledgments
Chapter 13: Natural compounds and retinal ganglion cell neuroprotection
- Abstract
- 1 Background
- 2 Cannabinoids
- 3 Coenzyme Q
- 4 Erigeron breviscapus
- 5 Erythropoietin
- 6 Estrogens
- 7 Flavonoids
- 8 Forskolin
- 9 Lycium barbarum
- 10 Neuroglobin
- 11 Prostaglandins
- 12 Taurine
- Acknowledgment
Chapter 14: Rho kinase inhibitor AMA0526 improves surgical outcome in a rabbit model of glaucoma filtration surgery
- Abstract
- 1 Introduction
- 2 Materials and Methods
- 3 Results
- 4 Discussion
- Acknowledgments
Index
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Giacinto Bagetta

Carlo Nucci