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New Strategies Targeting Cancer Metabolism - 1st Edition - ISBN: 9780128217832

New Strategies Targeting Cancer Metabolism

1st Edition

Anticancer Drugs, Synthetic Analogues and Antitumor Agents

Authors: Galal Elgemeie Reham Mohamed-Ezzat
Paperback ISBN: 9780128217832
Imprint: Elsevier
Published Date: 1st December 2021
Page Count: 600
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Description

New Strategies Targeting Cancer Metabolism: Anticancer Drugs, Synthetic Analogues and Antitumor Agents presents up-to-date synthetic strategies for three categories of antimetabolites: antifolates, purines and pyrimidines, the main classes of antimetabolites which are integrated into various pharmaceutical agents. Many of these antimetabolites are considered potent chemotherapeutic agents which have great impact potential on the current medicinal research. These main classes of antimetabolites are used in the treatment of critical diseases including cancer, malignancies, chronic inflammatory diseases, malaria, psoriasis, gastrointestinal diseases, microbial, Alzheimer’s disease, influenza virus, hepatitis C (HCV), HIV, rheumatoid arthritis and other autoimmune diseases.

In this book, insights into a broad array of novel compounds are reviewed, well-recognized synthetic approaches are emphasized for further drug development and discovery, and the biological evaluation of novel synthesized compounds are included. This comprehensive reference is a valuable resource for medicinal chemists working in drug discovery and development, as well as pharmacologists and biochemists working in related fields.

Key Features

  • Provides the only resource dedicated to synthetic strategies of antimetabolites
  • Features synthetic strategies for nucleosides and their analogues
  • Includes coverage of purine-, pyrimidine- and folate-based anticancer drugs

Readership

Organic and Medicinal Chemists working in drug discovery.
Biochemists, pharmacologists

Table of Contents

  1. Medicinal chemistry of Antimetabolites
    2. Folate-Based anti-cancer Drugs
    3. Pyrimidine-based anticancer drugs
    4. Purine-based anticancer drugs
    5. Synthetic Strategies for Antifolates and their Analogues
    6. Synthetic Strategies for Pyrimidine Nucleosides and their Analogues
    7. Synthetic Strategies for Purine Nucleosides and their Analogues1. Medicinal chemistry of Antimetabolites
    2. Folate-Based anti-cancer Drugs
    3. Pyrimidine-based anticancer drugs
    4. Purine-based anticancer drugs
    5. Synthetic Strategies for Antifolates and their Analogues
    6. Synthetic Strategies for Pyrimidine Nucleosides and their Analogues
    7. Synthetic Strategies for Purine Nucleosides and their Analogues

Details

No. of pages:
600
Language:
English
Copyright:
© Elsevier 2021
Published:
1st December 2021
Imprint:
Elsevier
Paperback ISBN:
9780128217832

About the Authors

Galal Elgemeie

Prof. Elgemeie is the author of over 230 scientific international papers on heterocyclic chemistry, medicinal chemistry and synthetic methodology. He has supervised the work of 35 Ph.D and 55 M.Sc. students. His research interests include the development and mechanistic understanding of organic reactions and their application to the synthesis of antimetabolic agents. Prof. Elgemeie was nominated as one of the leading scientists of the Member States of the Organization of Islamic Countries in the year 2009 Report. Prof. Elgemeie's research activities have received many awards including the Egypt Prize in Chemistry and The ISESCO Scientific Award, among many others.

Affiliations and Expertise

Department of Chemistry, Helwan University, Cairo, Egypt

Reham Mohamed-Ezzat

Reham Mohamed-Ezzat works in the Chemistry of Natural and Microbial Products Department at the National Research Center in Cairo, Egypt.

Affiliations and Expertise

Chemistry of Natural and Microbial Products Department, National Research Center, Cairo, Egypt

Ratings and Reviews