New Strategies Targeting Cancer Metabolism

New Strategies Targeting Cancer Metabolism: Anticancer Drugs, Synthetic Analogues and Antitumor Agents presents up-to-date synthetic strategies for three categories of antimetabolites: antifolates, purines and pyrimidines, the main classes of antimetabolites which are integrated into various pharmaceutical agents. Many of these antimetabolites are considered potent chemotherapeutic agents which have great impact potential on the current medicinal research. These main classes of antimetabolites are used in the treatment of critical diseases including cancer, malignancies, chronic inflammatory diseases, malaria, psoriasis, gastrointestinal diseases, microbial, Alzheimer’s disease, influenza virus, hepatitis C (HCV), HIV, rheumatoid arthritis and other autoimmune diseases.

In this book, insights into a broad array of novel compounds are reviewed, well-recognized synthetic approaches are emphasized for further drug development and discovery, and the biological evaluation of novel synthesized compounds are included. This comprehensive reference is a valuable resource for medicinal chemists working in drug discovery and development, as well as pharmacologists and biochemists working in related fields.

• Provides the only resource dedicated to synthetic strategies of antimetabolites
• Features synthetic strategies for nucleosides and their analogues
• Includes coverage of purine-, pyrimidine- and folate-based anticancer drugs

Organic and Medicinal Chemists working in drug discovery.
Biochemists, pharmacologists

1. Medicinal chemistry of Antimetabolites
   2. Folate-Based anti-cancer Drugs
   3. Pyrimidine-based anticancer drugs
   4. Purine-based anticancer drugs
   5. Synthetic Strategies for Antifolates and their Analogues
   6. Synthetic Strategies for Pyrimidine Nucleosides and their Analogues
   7. Synthetic Strategies for Purine Nucleosides and their Analogues1. Medicinal chemistry of Antimetabolites
   2. Folate-Based anti-cancer Drugs
   3. Pyrimidine-based anticancer drugs
   4. Purine-based anticancer drugs
   5. Synthetic Strategies for Antifolates and their Analogues
   6. Synthetic Strategies for Pyrimidine Nucleosides and their Analogues
   7. Synthetic Strategies for Purine Nucleosides and their Analogues