New Perspectives in Adipose Tissue

New Perspectives in Adipose Tissue

Structure, Function and Development

1st Edition - April 22, 1985

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  • Editors: A. Cryer, R. L. R. Van
  • eBook ISBN: 9781483163970

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New Perspectives in Adipose Tissue: Structure, Function and Development reviews the state of knowledge on adipose tissue. The book begins with discussions of the anatomy and morphology of adipose tissue. This is followed by separate chapters on the nervous control of circulation and metabolism in white adipose tissue; hormonal regulation of biosynthetic activities in white adipose tissue; hormonal control of lipid degradation; and plasma membrane properties and receptors in white adipose tissue. Subsequent chapters cover topics such as lipoproteins and adipose tissue; brown adipose tissue thermogenesis and energy balance in animals and man; methodological approaches to the study of the adipose tissues; adipose tissue growth following lipectomy; the adipocyte precursor cell; and adipose tissue dysfunction and its consequences. In addition to being authoritative source material, the chapters presented in this book are wide in their coverage and appeal.

Table of Contents

  • 1 The Comparative Anatomy of Adipose Tissue

    1.1 Introduction

    1.2 Anatomy of Adipose Tissue in the Fetus

    1.3 Cellularity of Adipose Tissue

    1.4 Stromal-Vascular Aspects of Adipose Tissue

    1.5 References

    2 The Morphology of Adipose Tissue

    2.1 Introduction

    2.2 White Adipose Tissue

    2.3 Brown Adipose Tissue

    2.4 Acknowledgments

    2.5 References

    3 Nervous Control of Circulation and Metabolism in White Adipose Tissue

    3.1 Introduction

    3.2 Innervation of White Adipose Tissue

    3.3 Control of Transmitter Release

    3.4 Nervous Control of Circulation

    3.5 Nervous Control of Metabolism

    3.6 Interplay between Circulation and Metabolism

    3.7 Pathophysiological Considerations—Adipose Tissue in Shock

    3.8 Summary and Conclusions

    3.9 Acknowledgments

    3.10 References

    4 The Metabolism of White Adipose Tissue In Vivo and In Vitro

    4.1 Introduction

    4.2 Methodological Aspects

    4.3 Blood Flow

    4.4 Lipoprotein Lipase and the Utilization of Plasma Triacylglycerol

    4.5 Fatty Acid Synthesis

    4.6 Esterification

    4.7 Lipolysis

    4.8 References

    5 Hormonal Regulation of Biosynthetic Activities in White Adipose Tissue

    5.1 Introduction

    5.2 Precursors of Biosynthesis: information Gained from Measurements of Metabolic Fluxes

    5.3 The Provision of Precursors

    5.4 Conversion of Intracellular Glucose to Triosephosphates and to Pyruvate

    5.5 Control of the Pyruvate Dehydrogenase (PDH) Complex

    5.6 Acetyl CoA Carboxylase

    5.7 Other Enzymes Associated with the FAS Pathway

    5.8 The Esterification Pathway

    5.9 References

    6 Hormonal Control of Lipid Degradation

    6.1 Introduction

    6.2 The Rate-Controlling Enzyme: The Hormone-Sensitive Lipase

    6.3 Short-term Hormonal Control of Lipolysis

    6.4 Conclusions and Perspectives

    6.5 Acknowledgments

    6.6 References

    7 Plasma Membrane Properties and Receptors in White Adipose Tissue

    7.1 Introduction

    7.2 Methodological Approaches for the Study of the Fat Cell Plasma Membrane

    7.3 Plasma Membrane Receptors: identification, Characterization and Purification

    7.4 Summary and Concluding Remarks

    7.5 References

    8 Lipoproteins and Adipose Tissue

    8.1 The Plasma Lipoproteins

    8.2 The Lipoproteins and Adipose Tissue

    8.3 The Relation of Adipose Tissue Cholesterol Storage to Circulating Lipoprotein Cholesterol

    8.4 Conclusion

    8.5 References

    9 The Role of Brown Adipose Tissue Thermogenesis in Energy Balance

    9.1 Introduction

    9.2 BAT Thermogenesis and Energy Balance in Normal Animals

    9.3 BAT Thermogenesis and Energy Balance in obese Animals

    9.4 Role of BAT Thermogenesis in Energy Balance in Man

    9.5 Conclusion and Implications for the Future

    9.6 References

    10 Brown Adipose Tissue: Molecular Mechanisms Controlling Activity and Thermogenesis

    10.1 Brown Adipose Tissue is not White Adipose Tissue

    10.2 The Energy-Consuming, Heat-Producing Function of BAT

    10.3 Heat Production In Vitro

    10.4 The Question of the Nature of the Intracellular Mediator of Thermogenesis

    10.5 The Recovery Processes

    10.6 Physiological Recruitment of the Thermogenic Capacity of BAT

    10.7 Perspectives

    10.8 Acknowledgments

    10.9 References

    11 Methodological Approaches to the Study of the Adipose Tissues: Their Impact on Research into the Aetiology of Obesity

    11.1 Introduction

    11.2 Methodological Approaches to Determine whether the Increased White Fat Cell Size of Genetically Obese Rodents is Caused by their Nature or their Nurture

    11.3 Methodological Approaches to the Measurement of Blood Flow to BAT

    11.4 Methodological Approaches to the Identification of the Adipose Tissues

    11.5 Concluding Remarks

    11.6 Acknowledgments

    11.7 References

    12 Regulation of Adipose Tissue Development in Utero

    12.1 Introduction

    12.2 Metabolic Development

    12.3 Effectors of Fetal Adipose Tissue Development

    12.4 Genetic Aspects

    12.5 Central Mechanisms

    12.6 Summary

    12.7 Acknowledgment

    12.8 References

    13 Growth of Adipose Tissue following Lipectomy

    13.1 Introduction

    13.2 Animal Experiments

    13.3 Use of Lipectomy to Study Regulation of Body Fat Mass: 'Lipodynamics'

    13.4 Lipectomy in Man

    13.5 References

    14 Cell and Tissue Culture Models of Adipocyte Development

    14.1 Introduction

    14.2 Models of Adipocyte Differentiation Using Cells Derived from Adipose Tissue

    14.3 Models of Adipocyte Differentiation Using Cells Derived from Non-Adipose Tissue

    14.4 Factors Affecting Adipocyte Differentiation

    14.5 Structural and Functional Changes during Adipocyte Differentiation In Vitro

    14.6 Concluding Remarks

    14.7 Acknowledgments

    14.8 References

    15 The Adipocyte Precursor Cell

    15.1 Introduction

    15.2 Adipocyte Precursors In Vitro

    15.3 Functional Characteristics of Adipocyte Precursors

    15.4 Effect of Hormones on Adipocyte Precursors

    15.5 Effect of Growth Factors

    15.6 Adipocyte Precursor Clones

    15.7 Development of Adipocyte Precursors In Vivo

    15.8 Adipocyte Delipidation

    15.9 The Nature of the Adipocyte

    15.10 Adipocyte Precursor Characteristics in Human and Animal Obesities

    15.11 New Perspectives in Adipose Cellularity

    15.12 References

    16 Biochemical Markers of Adipocyte Precursor Differentiation

    16.1 Introduction

    16.2 Measurements of Overall Metabolic Changes

    16.3 Activities of Intracellular Enzymes of Lipid Metabolism

    16.4 Changes in the Levels of other Proteins

    16.5 Changes in the Responses to Hormones

    16.6 Cell Surface Changes

    16.7 Postscript

    16.8 References

    17 The Role of Hormone Status in the Development of Excess Adiposity in Animal Models of Obesity

    17.1 Introduction

    17.2 Hormone Secretion in Animal Obesities

    17.3 Regulation of Food Intake

    17.4 Hormonal Control of Energy Expenditure

    17.5 Hormonal Control of Lipid Metabolism in Obesity

    17.6 Adipose Tissue Development in Animal Obesities

    17.7 Concluding Remarks

    17.8 References

    18 Adipose Tissue Dysfunction and its Consequences

    18.1 Introduction

    18.2 Obesity and Adipose Tissue Morphology

    18.3 Endocrine Regulation of Adipocytes

    18.4 Regional Obesity and Classification

    18.5 Integration of Regional Obesity Data and Adipocyte Function

    18.6 Summary, Outlook and Conclusions

    18.7 References


Product details

  • No. of pages: 490
  • Language: English
  • Copyright: © Butterworth-Heinemann 1985
  • Published: April 22, 1985
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483163970

About the Editors

A. Cryer

R. L. R. Van

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