New Insights on the Development of the Vascular System

New Insights on the Development of the Vascular System

1st Edition - September 1, 2022

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  • Author: Domenico Ribatti
  • Paperback ISBN: 9780323905992

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Description

New Insights on the Development of the Vascular System examines the most recent literature and data on the development of the vascular system, along with advice on new laboratory techniques and approaches to data analysis. This volume is a comprehensive handbook to the state-of-the-art in vascular system development. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system, and there is extensive literature on the genetic background and molecular mechanisms responsible for blood vessel formation. Yet new data and techniques have been developed in recent years. Although scientific literature covers the descriptive aspects of embryonic vascular system development, modern techniques such as the technology of cell fusion, cell sorting and image analysis give new insight into the mechanisms by which vessels form and regress and how blood flow changes directions in the same vessels.

Key Features

  • Gives a comprehensive overview of the most recent literature in the field of vascular system development
  • Presents new data, including sections on endothelial cell signaling and technologies of cell fusion, cell sorting and image analysis
  • Provides useful insights on the analysis of new experimental work
  • Suggests modern techniques for scientists to use in the lab
  • Gives an overview of vascular biology that will be useful for those needing rapid familiarity
  • Provides an expert guide to the state-of-the-art in vascular system development as written by a leader in the field

Readership

Researchers in biochemistry, vascular biology, cell and molecular biology, physiology, neurology, oncology, pathology, cardiology, rheumatology, ophthalmology, and genetics. Advanced students in vascular biology and pharmaceutics

Table of Contents

  • 1. Vasculogenesis
    2. Angiogenesis
    3. Key regulators of endothelial sprouting
    4. Endothelial tip, stalk, and phalanx cells
    5. Role of VEGF and VEGFRs
    6. Role of notch and notch ligands
    7. Role of microRNA
    8. Lumen formation and perfusion
    9. Network formation
    10. Remodeling
    11. Pruning
    12. Maturation and stabilization (pericyte recruitment)
    13. Non-sprouting angiogenesis (intussusceptive microvascular growth, IMG)
    14. Arterial-venous specificationForeword
    15. Vasculogenesis
    16. Angiogenesis
    17. Key regulators of endothelial sprouting
    18. Endothelial tip, stalk, and phalanx cells
    19. Role of VEGF and VEGFRs
    20. Role of notch and notch ligands
    21. Role of microRNA
    22. Lumen formation and perfusion
    23. Network formation
    24. Remodeling
    25. Pruning
    26. Maturation and stabilization (pericyte recruitment)
    27. Non-sprouting angiogenesis (intussusceptive microvascular growth, IMG)
    28. Arterial-venous specification

Product details

  • No. of pages: 210
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: September 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323905992

About the Author

Domenico Ribatti

Domenico Ribatti is Professor of Human Anatomy, in the Department of Basic Biomedical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Italy. He was awarded his M.D. degree in 1981, with full marks. In 1983, he joined the Medical School as Assistant at the Institute of Human Anatomy, University of Bari. In 1984, he took the specialization in Allergology. In 1989, he spent one year in Geneva, working at the Department of Morphology. In 2008, he received the honoris causa degree in Medicine and Pharmacy form the University of Timisoara, Romania. He is the author of over 800 publications and 50 chapters, as well as a number of books for Elsevier/Academic Press including: Milestones in Immunology (2017) In Vivo Models to Study Angiogenesis (2017) Immunology in the Twentieth Century (2018) Tumor Vascularization (2020) Tumor Microenvironment Regulation of Tumor Expansion (2021) .

Affiliations and Expertise

Professor of Human Anatomy, Department of Basic Biomedical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy

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