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New Concepts of Psychostimulants Induced Neurotoxicity - 1st Edition - ISBN: 9780123745040, 9780080922904

New Concepts of Psychostimulants Induced Neurotoxicity, Volume 88

1st Edition

Editor: Hari Shanker Sharma
Hardcover ISBN: 9780123745040
eBook ISBN: 9780080922904
Imprint: Academic Press
Published Date: 5th November 2009
Page Count: 472
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Table of Contents

1. Effects of psychostimulants on neurotrophins: implications for psychostimulant-induced neurotoxicity. Francesco Angelucci, Italy.

2. Dopamine-Induced Behavioral Changes and Oxidative Stress in Methamphetamine-induced Neurotoxicity. Taizo Kita, Japan

3. Molecular bases of methamphetamine-induced neurodegeneration. Jean Lud Cadet, USA

4. Ethanol alters the physiology of neuron-glia communication. Antonio González , Spian

5. Therapeutic targeting of "DARPP-32" a key signaling molecule in the dopiminergic pathway for the treatment of opiate addiction. Supriya D. Mahajan , USA

6. Mechanisms of action for bupropion and diethylpropion at the brain, cellular, and molecular levels. Hugo R. Arias, Mexico

7. Dosing time-dependent actions of psychostimulants. H. Manev, USA

8. Methamphetamine induced neurotoxicity. Eugene Kiyatkin, USA

9. Serotonin modulating AP compounds attenuate morphine withdrawal induced neurotoxicity. Torbjörn Lundstedt, Sweden

10. Methamphetamine and the blood-brain barrier. Ali SF, USA

11. Morphine induced heat shock protein expression. Relevance to Neurotoxicity and Neurorepair. Dafin Muresanu, Romania

12. Psychotimulants and the blood-CSF barrier. Conrad Johanson, USA

13. MDMA induces blood-brain barrier disruption and neurotoxicity, Hari S Sharma, Sweden

14. Temperature, stress and MDMA neurotoxicity, James O'Callaghan, USA

15. Amphetamine substitute and neuronal activation. D Miller, USA

16. Cannabinoid receptors and the pathology of drug abuse, E. Onaivi, USA

17. Nanoparticles influence Morphine dependece and withdrawal. Hari S Sharma

18. Neuropharmacological profile of GHB abuse, T J Maher, USA

19. Histamine modulation in morphine dependence and withdrawal. Ranjana Patnaik, Varanasi, India

20. Morphine dependence and withdrawal influences spinal cord injury induced neurotoxicity. Amit K Ray, Varanasi, India

21. Neurochemical and microvascular reactions during morphine dependence and withdrawal. Mark A Smith, USA.


Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

With recent advancements in new knowledge, it has become evident that psychostimulants and related drugs of abuse are influencing our central nervous system (CNS) remarkably and could alter their function for a longtime. This volume is the first to focus on substance abuse induced brain pathology in the widest sense as it covers alterations in neuronal, glial and endothelial cell functions under the influence of acute or chronic usage of substance abuse.


Neuroscientists and neurologists


No. of pages:
© Academic Press 2009
5th November 2009
Academic Press
Hardcover ISBN:
eBook ISBN:


Praise for the Series:
"A valuable addition to any college library as current reference material for advanced undergraduates, graduate students, and professional scientists." - Choice

Ratings and Reviews

About the Editor

Hari Shanker Sharma

Dr. Hari Shanker Sharma, Professor of Neurobiology (MRC), Docent in Neuroanatomy (UU) is currently working in Uppsala University Hospital, Department of Surgical Sciences, Division of Anesthesiology & Intensive Care Medicine, Uppsala University, Sweden. Dr Sharma obtained his Masters Degree from Bihar University with special expertise in Cell Biology in 1976 and was awarded the Gold Medal of Bihar University for securing 1st position in the 1st Class. Dr Sharma joined the group of Professor Prasanta Kumar Dey, a neurophysiologist, by training in the Department of Physiology, Institute of Medical; Sciences, Banaras Hindu University, Varanasi in 1977 to obtain his Doctor of Philosophy Degree (D.Phil.) in Neurosciences and was awarded his Ph.D. in 1982 on “Blood-Brain Barrier in Stress.” After carrying out a series of Government of India funded Research Projects on the BBB and brain dysfunction (1982–1987), Dr Sharma joined the lab of Neuropathology at Uppsala University with Professor Yngve Olsson in 1988 to investigate passage of tracer transport across the BBB caused by stress or traumatic insults to the Brain and Spinal cord at light and electron microscopy. Dr Sharma was awarded the prestigious Alexander von Humboldt Foundation Fellowship of German Government (1989–1991) to work on hyperthermia induced BBB dysfunction at the ultrastructural level in the laboratory of Professor Jorge Cervós-Navarro (a living “Legend in Neuropathology in Europe”). Dr Sharma again joined Uppsala University and established a network of collaboration on “Experimental CNS Injury Research Group” as a lead investigator with eminent collaborators in various parts of Europe, USA, and Australia (1991–). On his work on hyperthermia Dr Sharma received the prestigious Neuroanatomy award “Rönnows Research prize” of Uppsala University for “best neuroanatomical research of the year 1996” followed by the Award of the Degree of Doctor of Medical Sciences of Uppsala University in Neuroanatomy in 1999 and selected for the Best Thesis Award of the Medical faculty, “The Hwassers Prize” of 1999. On his meticulous works on the Blood Brain barrier and Brain edema (2000–2003) Dr. Sharma earned the prestigious title of “Docent in Neuroanatomy” of Medical Faculty, Uppsala University in April 2004. Currently his main research interest is Neuroprotection and Neuroregeneration, in relation to the Blood-brain barrier in stress, trauma, and drugs of abuse in health and disease. Dr. Sharma on his research on brain pathology and neuroprotection in different models received the prestigious award from The Laerdal Foundation of Acute Medicine, Stavanger, Norway, in 2005 followed by Distinguished International Scientists Collaboration Award by National Institute on Drug Abuse (NIDA), Baltimore, MD (2006–2008). His recent work on 5-HT3 receptor mediated neuroprotection in morphine withdrawal induced neurotoxicity won the coveted prize of Best Investigator Award 2008 and Best Scientific Presentation by European Federation of the International Association for Study of Pain (ISAP), and Awarded during their VI Annual Meeting in Lisbon, September 9–12, 2008. His recent research is aimed to find out the role of nanoparticles in Neurodegeneration and Neuroprotection using various treatment strategies that is supported by European Aerospace Research and Development (EOARD), London, UK and US Air Force Research Laboratory, Wright Patterson Air Force Base, Dayton, Oh, USA. On his works on Blood–brain barrier in hypertension and diabetes together with Romanian colleagues, University of Medicine and Pharmacy “Iuliu Hatieganu,” Cluj-Napoca, Romania awarded Dr. Sharma with Honorary Doctorate of Medical Sciences in 2009. Dr Sharma’s work over 30 years on the blood-brain barrier and brain edema won him the US Neurosurgeon Dr Anthony Marmarou Award (2011) by the International Brain Edema Society at their 15th Congress in Tokyo, Japan, November 2011. His works on Nanoneuroscience and development of nanomedicine to treat the CNS injuries has won accolades at various Government and International Scotties or Organization across the World. Accordingly Dr Sharma was decorated with the most prestigious ”Hind Rattan Award 2012” on the eve of Republic Day of India in January 2012 and Mahatma Gandhi Pravasi Gold Medal in October 2012 in House of Lords, London, UK. Dr Sharma was also invited to organize and chair Nanosymposium in Society for Neuroscience meetings in Chicago (2009), San Diego (2010), Washington DC (2011) and New Orleans (2012). Dr Sharma has published over 380 research papers, 75 reviews, 12 monographs, and 70 international book chapters and edited 15 book volumes.

Affiliations and Expertise

Professor, Uppsala University, Sweden