New Combination Approaches to Enhance Rituximab-Based Lymphoma Therapies - 1st Edition - ISBN: 9780128164075

New Combination Approaches to Enhance Rituximab-Based Lymphoma Therapies

1st Edition

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Series Volume Editors: Benjamin Bonavida
Hardcover ISBN: 9780128164075
Imprint: Academic Press
Published Date: 1st July 2020
Page Count: 250
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Table of Contents

  1. Introduction
    2. Sensitization by Radiotherapy for Rituximab Mediated Cytotoxicity
    3. Sensitization by Bortexomib for Rituximab Mediated Cytotoxicity
    4. Sensitization by Complement Inhibitor for Rituximab-Mediated Cytotoxicity
    5. Sensitization by Immunomodulation Agents for Rituximab-Mediated Cytotoxicity
    6. Combination of Obinutuzumab and Rituximab for Rituximab-Mediated Cytotoxicity
    7. Inhibitor of Tumor Suppressors for Sensitization to Rituximab-Mediated Cytotoxicity
    8. Sensitization Fusion Protein Containing Anti-CD20 Antibody
    9. Inhibitors of Cell Signaling for Sensitization to Rituximab for Rituximab-Mediated Cytotoxicity
    10. Sensitization by Anti-Apoptotic Inhibitors to Rituximab-Mediated Cytotoxicity
    11. Sensitization by Chemotherapy to Rituximab-Mediated Cytotoxicity
    12. Sensitization by HDAC Inhibitors to Rituximab-Mediated Cytotoxicity


New Combination Approaches to Enhance Rituximab-Based Lymphoma Therapies provides general updated information on the resistance of various human lymphoma/leukemia subtypes to anti-CD20 therapeutic antibodies. It discusses also the description of various targeted sensitizing agents that can reverse innate or acquired resistance when used in combination with various FDA-approved anti-CD20 antibodies.

There have been a lot of reports in which the treatment with anti-CD20 antibodies for various lymphomas/leukemias has resulted in significant clinical responses; however, there have been also subsets of cancer patients who did not respond initially and several of the responding patients developed resistance to subsequent treatments with the same or different regimens. Therefore, the use of various immunosensitizing agents targeting resistant factors to reverse resistance has been considered and this book discusses each of them in depth, such as Bortexomib, Immunomodulation Agents, Obinutuzumab, Tumor Suppressors, and HDAC Inhibitors.

This book is a valuable source for cancer researchers, oncologists, pharmacologists and different members of biomedical field interested in fighting cancer resistance to anti-CD20 antibodies.

Key Features

  • Provides a general overview of various sensitizing agents that can work effectively when used in combination with anti-CD20 antibodies to reverse resistance
  • Offers potential underlying mechanisms by which the cancer cells are either inherently resistant or become unresponsive to further antibody treatments
  • Discusses how to develop new targeted agents to underlie resistance in order to expand research on this field


Cancer researchers; medical oncologists; clinicians; pharmacologists; translational investigators


No. of pages:
© Academic Press 2020
1st July 2020
Academic Press
Hardcover ISBN:

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About the Series Volume Editors

Benjamin Bonavida Series Volume Editor

Dr. Bonavida is internationally renowned by his expertise and various publications in the field of tumor cell sensitization to chemotherapy and in particular the novel role of Nitric Oxide (NO) donors in chemo-sensitization and reversal of drug resistance. He was the first individual to co-organize the first international workshop on NO and Cancer with Dr. Jean-François Jeannin in Paris. Subsequently, they co-organized three additional conferences on the same topic. The last fourth workshop was held in March in Sevilla, Spain with Dr. Muntane, and the proceedings were published in Redox Biology recently. These conferences focus on NO and derivatives in cancer and their therapeutic applications in resistant cancer.

Affiliations and Expertise

Professor, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, USA