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New and Future Developments in Microbial Biotechnology and Bioengineering - 1st Edition - ISBN: 9780444635051, 9780444635136

New and Future Developments in Microbial Biotechnology and Bioengineering

1st Edition

Aspergillus System Properties and Applications

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Editor: Vijai Gupta
Hardcover ISBN: 9780444635051
eBook ISBN: 9780444635136
Imprint: Elsevier
Published Date: 2nd August 2016
Page Count: 314
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New and Future Developments in Microbial Biotechnology and Bioengineering: Aspergillus System Properties and Applications provides information on emerging issues related to recent advancements in aspergillus research and its applications in bioprocess technology, chemical engineering, genome biology, molecular taxonomy, secondary and metabolite production, industrial process and biofuels/bioenergy research, and alternative fuel development. The book covers the various novel enzymes secreted by these fungi and their specific use in the food, textile, pulp and paper, biocellulosic ethanol production, and other industries.

The book describes research and experimentation on aspergillus activity and directly connects them to their use in bioprocess technology, chemical engineering, bioremediation process, secondary metabolite production, pharmaceutical processes, protein production, industrial process, biofuels/bioenergy research, and alternative fuel development. Readers will find this book to be an indispensable resource for biotechnologists, biochemical engineers, biochemists, microbiologists, bioinformatics researchers, and other biologists who are interested in learning about the potential applications of these fungi.

Key Features

  • Compiles available, up-to-date information on recent developments made in the study of aspergillus system properties
  • Contains global content from pioneering international authors
  • Presents current research efforts and links them to various applications, including uses in foods, textiles, pulp and paper, and in biocellulosic ethanol production
  • Provides an indispensable resource for biologists who are interested in learning about the potential applications of the fungi aspergillus


Bioengineers, Biochemical Engineers, Biochemists, Biotechnologists, food technologists, enzymologists, and related Professionals/ researchers. Graduate and postgraduate students, researchers and microbiologists, mycologists.

Table of Contents

  • List of Contributors
  • Section I: Biology and Biodiversity
    • Chapter 1. Biodiversity of the Genus Aspergillus in Different Habitats
      • Abstract
      • Introduction
      • Methodology of Studying Aspergillus Biodiversity
      • Aspergillus Diversity in Different Habitats
      • Conclusions
      • References
    • Chapter 2. Understanding the Diversity of Aspergillus by Next-Generation Sequencing
      • Abstract
      • Introduction
      • Methods for the Diversity Assessments of Different Aspergillus Species
      • Conclusion
      • References
    • Chapter 3. Molecular Evolution of Aspergillus
      • Abstract
      • Aspergillus Generalities
      • Aspergillus Role in Nature
      • Aspergillus Diversity
      • Genome Sequencing of Aspergillus Species
      • Future Trends
      • References
  • Section II: Secretion and Protein Production
    • Chapter 4. Heterologous Expression of Proteins in Aspergillus
      • Abstract
      • Historical Context
      • Biosafety
      • Fermentation Systems for Protein Production in Aspergillus: Scale-Up
      • Homologous Protein Production for Industrial Application
      • Enhancing Heterologous Protein Expression
      • Human Proteins Expressed in Aspergillus
      • Synthetic Biology as an Innovative Approach for the Biosynthesis of Novel Compounds
      • Bioremediation
      • References
    • Chapter 5. Aspergillus Secretome: An Overview
      • Abstract
      • Introduction
      • Secretome
      • Access to Secretome
      • Genomic Analysis
      • Bioinformatics Approach
      • Recent Breakthroughs
      • Conclusion
      • References
  • Section III: Secondary Metabolism
    • Chapter 6. Secondary Metabolism and Antimicrobial Metabolites of Aspergillus
      • Abstract
      • Introduction
      • Metabolites
      • Polyketides
      • Lovastatin
      • Aflatoxin B1
      • Ochratoxin
      • Enzymes
      • Lipases
      • Laccases
      • Tannases
      • Pectinases
      • Proteases
      • Lactases
      • Cellulases
      • Amylases
      • Organic Acids
      • Citric Acid
      • Itaconic Acid
      • Kojic Acid
      • Gluconic Acid
      • Final Remarks
      • Acknowledgments
      • References
    • Chapter 7. Fungal Volatile Organic Compounds (VOCs) and the Genus Aspergillus
      • Abstract
      • Introduction to Volatile Organic Compounds
      • VOCS as Taxonomic Characters and as Indicators of Fungal Growth
      • VOCS as Aroma Compounds
      • Physiological Effect of Aspergillus VOCS
      • VOCS as Products of Aspergillus Enzymatic Biotransformations
      • Summary and Prospects for Future Research
      • References
  • Section IV: Tools
    • Chapter 8. Molecular Tools for Strain Improvement in Aspergillus
      • Abstract
      • Introduction
      • Aspergillus Strain Improvement
      • Strain Mating Approach
      • Gene Targeting Approach: Functional Loss of Target Gene Conferring Toxicity
      • Promoter Analysis
      • Application of RNA Interference
      • Desired Gene Fusion with a Strongly Expressed Genes
      • Site-Directed Insertional Mutagenesis
      • Conclusions
      • References
  • Section V: Applications
    • Chapter 9. Enzyme System from Aspergillus in Current Industrial Uses and Future Applications in the Production of Second-Generation Ethanol
      • Abstract
      • Introduction
      • Biodiversity and Bioprospecting
      • Enzyme System from Aspergillus Applied in Current Industrial Uses and Second-Generation Ethanol
      • Perspectives and Concluding Remarks
      • Acknowledgments
      • References
    • Chapter 10. Advances in Cultivation Strategies of Aspergillus for Production of Enzymes Involved in the Saccharification of Lignocellulosic Feedstocks
      • Abstract
      • Introduction
      • Enzymes Involved in the Saccharification of Lignocellulosic Feedstocks
      • Cultivation of Aspergillus Under SmF
      • Cultivation of Aspergillus Under SSF
      • Novel Approaches for (Hemi)Cellulolytic Enzyme Production by Aspergillus
      • Concluding Remarks
      • References
    • Chapter 11. β-Glucosidase From Aspergillus
      • Abstract
      • Introduction
      • Aspergillus as Enzyme Producers
      • Production of β-Glucosidase using Aspergillus Strains
      • Purification and Characterization of β-Glucosidases
      • Engineering of Aspergillus Strains and β-Glucosidase from Aspergillus
      • Applications of β-Glucosidase from Aspergillus
      • Immobilization of β-Glucosidases from Aspergillus sp.
      • Conclusions
      • References
    • Chapter 12. Regulation and Heterologous Expression of Lignocellulosic Enzymes in Aspergillus
      • Abstract
      • Introduction
      • Structure of Plant Cell Wall
      • The Lignocellulolytic System
      • Regulation of Lignocellulolytic Enzymes in Aspergillus Species
      • Heterologous Expression in Aspergillus
      • Conclusions
      • References
    • Chapter 13. Aspergillus Enzymes for Textile Industry
      • Abstract
      • Textile Industry: A Major Industrial Sector Worldwide
      • Microbial Enzymes for the Textile Industry: Revolutionary Step in the Industrial World
      • Fungal Enzymes for Textile Industry
      • Aspergillus Species
      • Aspergillus sp. for Industrial Applications
      • Future Scope
      • References
    • Chapter 14. Biosynthesis of Nanoparticles by Aspergillus and Its Medical Applications
      • Abstract
      • Introduction
      • Metal Nanoparticles
      • Methods Employed for NP Synthesis
      • Medical Use and Importance
      • Diagnostics
      • Antimicrobial Properties
      • Hyperthermia
      • Drug Delivery
      • Toxicity
      • Final Remarks and Perspectives
      • Acknowledgments
      • References
    • Chapter 15. Role of Aspergillus in Bioremediation Process
      • Abstract
      • Introduction
      • A Brief Scenario of Soil and Water Pollution and the Adverse Effects
      • Bioremediation: Its Necessity
      • HM Bioremediation by Aspergillus
      • Mechanism of HM Tolerance by Aspergillus
      • Bioremediation of Hydrocarbons by Aspergillus
      • Role of Aspergillus sp. in Textile Wastewater Cleaning
      • Conclusion
      • References
    • Chapter 16. Applications of Aspergillus in Plant Growth Promotion
      • Abstract
      • Introduction
      • Phosphorous Solubilization/Mineralization
      • Secondary Metabolites
      • Phytohormone
      • Conclusion
      • References
    • Chapter 17. Aspergillus in Biomedical Research
      • Abstract
      • Introduction
      • Future Prospects of Using Aspergillus in Biomedical Research
      • References
    • Chapter 18. Aspergillus Applications in Cancer Research
      • Abstract
      • Introduction
      • Conclusions and Future Perspectives
      • References
    • Chapter 19. Protein Production: Quality Control and Secretion Stress Response
      • Abstract
      • Introduction
      • Genetic Strategies
      • Bioprocessing Strategies
      • Conclusion
      • References
  • Index


No. of pages:
© Elsevier 2016
2nd August 2016
Hardcover ISBN:
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About the Editor

Vijai Gupta

Vijai K. Gupta has previously worked as- Senior Scientist, ERA Chair VALORTECH, Estonian University of Life Sciences, Estonia; Senior Scientist, ERA Chair Green Chemistry, Tallinn Technical University, Estonia and Senior Researcher, Molecular Glycobiotechnology Group Department of Biochemistry. NUI Galway Ireland. Currently, he working as Professor (Associate) of Biochemistry at UM6P University, Morocco. Dr. Gupta’s present work is focused on the development and optimization of novel enzyme-based bioconversion systems for biorefining and bioenergy, bioactive natural products and biomass to bioproduct valorisation using microbial technologies. He has 122 publications with h-index 36 and RG Score 41.25

Affiliations and Expertise

Professor, AgroBioSciences (AgBS) and Chemical and Biochemical Sciences (CBS) Department, Mohammed VI Polytechnic University (UM6P), Benguerir, Morocco

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