This volume in the Handbook of Clinical Neurology series provides a complete review of the history, science and current state of neurovirology. It covers the science and clinical presentation, diagnosis, and treatment of viruses of the brain and central nervous system, and is a trusted resource for scholars, scientists, neuroscientists, neurologists, virologists, and pharmacologists working on neurovirology.

Neurovirology has been significantly bolstered by modern technologies such as PCR and MRI with direct impact on isolating viruses and advancing therapeutics based on molecular medicine. These advances are particularly important today with the introduction of emerging and re-emerging diseases such as HIV/AIDS, Nipah encephalitis and the appearance of West Nile encephalitis in the western hemisphere.

Key Features

  • Detailed coverage of neurovirology from the basic science to clinical presentation
  • Covers advances in neurovirology via polymerase chain reaction (PCR) and MRI technology
  • Covers emerging and re-emerging diseases including HIV/AIDS, Nipah encephalitis, and the appearance of West Nile encephalitis in the western hemisphere


Clinical neurologists at tertiary centers and neuroscience researchers

Table of Contents

  • Handbook of Clinical Neurology 3rd Series
  • Foreword
  • Preface
  • SECTION 1: Introduction
    • Chapter 1: A history of viral infections of the central nervous system: foundations, milestones, and patterns
      • Abstract
      • Introduction
      • Foundations
      • Milestones
      • Conclusions: patterns observed and patterns predicted
    • Chapter 2: Basics of virology
      • Abstract
      • Introduction
      • What is a virus?
      • Virus taxonomy and nomenclature
      • Virion structure
      • Virus origins and evolution
      • Virus replication cycles
      • Neurotropic viruses
      • Fundamental aspects of viral pathogenesis
      • Immunity to viruses
      • Diagnosis of viral infections
      • Antivirals
    • Chapter 3: Neuroepidemiology and the epidemiology of viral infections of the nervous system
      • Abstract
      • Introduction
      • Epidemiology of viral infections of the nervous system
      • Summary
    • Chapter 4: Clinical approach to the syndromes of viral encephalitis, myelitis, and meningitis
      • Abstract
      • Introduction
      • Definitions of viral central nervous system infection syndromes
      • Viral encephalitis
      • Viral meningitis
      • Viral myelitis
      • Suggested investigations for viral CNS infections
      • Suggested treatment for CNS viral infection
    • Chapter 5: Laboratory diagnosis of viral infection
      • Abstract
      • Introduction
      • General principles of laboratory viral diagnosis
      • Viral diagnostic methods
      • Sample collection and transport
      • Summary and interpretation of test results
    • Chapter 6: Neuroimaging of viral infections of the central nervous system
      • Abstract
      • Basic principles of imaging
      • Herpesviruses
      • Arbovirus
      • Nipah and hendra virus
      • Adenovirus
      • Arena


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About the editors

Alex Tselis

I graduated with a B Sc in physics from McGill University in Montreal in 1978. I obtained my PhD in physics from Brown University in 1983. After postdoctoral work at Purdue University, I entered medical school at the University of Miami in Florida, graduating with my MD in 1987. I trained in clinical neurology at Northwestern University and Duke University, followed by postdoctoral training in neurovirology at the University of Pennsylvania, 1991-1994. Since 1994 I have been on the faculty at the Department of Neurology at Wayne State University.

Affiliations and Expertise

Department of Neurology, Detroit Medical Center, Wayne State University, Detroit, MI, USA

John Booss

My laboratory work had been in the virology of the nervous system and in viral immunology with emphasis on the cytomegaloviruses. Clinically my interests had been in viral encephalitis, multiple sclerosis, and HIV of the nervous system. From 1993 until my retirement in 2005, I was the National Program Director for Neurology for the Department of Veterans Affairs. Our goal was to have neurological services coordinated nationally. During that time we were able to establish national centers of excellence for Parkinson’s Disease and Multiple Sclerosis. Just after my retirement, a coalition of organizations led by the American Academy of Neurology convinced the Congress to establish national VA centers of excellence in epilepsy. I am presently interested in historical subjects including historical virology: see for example To Catch a Virus, Booss and August, ASM Press, 2013; and Neurovirology in the Elsevier series Handbook of Clinical Neurology, eds, Tselis and Booss, forthcoming, 2014.

Affiliations and Expertise

Virology Labs, West Haven, CT, USA