Neurotrophins - 1st Edition - ISBN: 9780128122631, 9780128122648

Neurotrophins, Volume 104

1st Edition

Serial Editors: Gerald Litwack
eBook ISBN: 9780128122648
Hardcover ISBN: 9780128122631
Imprint: Academic Press
Published Date: 15th February 2017
Page Count: 550
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Table of Contents

Chapter One: Crystal Structures of Neurotrophin Receptors Kinase Domain

  • Abstract
  • 1 Introduction
  • 2 Crystal Structure of TrkA, TrkB, and TrkC Kinase Domain
  • 3 Pharmacological Approach: The Selectivity Issue
  • 4 Conclusion and Future Directions
  • Acknowledgments

Chapter Two: BDNF Propeptide: A Novel Modulator of Synaptic Plasticity

  • Abstract
  • 1 Neurotrophins and Their Biological Actions
  • 2 NT Receptors and Their Signaling
  • 3 Synthesis, Intracellular Trafficking, and Secretion of BDNF Protein
  • 4 Modulation of Synaptic Function by BDNF
  • 5 BDNF Prodomain: New Roles Beyond a Molecular Chaperone
  • 6 BDNF and Its Propeptide Are Localized in Presynaptic Dense Core Vesicles
  • 7 The BDNF Propeptide Is a Novel Synaptic Modulator
  • 8 Role of the Val66Met Polymorphism in BDNF Propeptide-Dependent LTD
  • 9 Discussion

Chapter Three: Zinc Interactions With Brain-Derived Neurotrophic Factor and Related Peptide Fragments

  • Abstract
  • 1 Introduction
  • 2 Brain-Derived Neurotrophic Factor
  • 3 Zinc in the Brain
  • 4 Zinc(II) Interaction With BDNF and Related Peptides
  • 5 Zinc, BDNF, and Diet
  • 6 Conclusion
  • Acknowledgments

Chapter Four: Structural Characterization of the p75 Neurotrophin Receptor: A Stranger in the TNFR Superfamily

  • Abstract
  • 1 TNFR Superfamily
  • 2 Structural Characterization of p75NTR
  • 3 The Transmembrane Domain (TMD)
  • 4 The Intracellular Domain (ICD)
  • 5 Conclusions and Future Directions
  • Acknowledgments

Chapter Five: Releasing Mechanism of Neurotrophic Factors via Polysialic Acid

  • Abstract
  • 1 Introduction
  • 2 Biochemical Features of BDNF
  • 3 Regions and Cellular Distribution of BDNF
  • 4 Extracellular Secretion of BDNF
  • 5 Conclusion
  • Acknowledgments

Chapter Six: Emergent Role of Coronin-1a in Neuronal Signaling

  • Abstract
  • 1 Introduction
  • 2 The Coronin Family of Proteins
  • 3 Type I Coronins as Actin Regulators
  • 4 Coronin-1a as a Signaling Effector Protein
  • 5 Conclusions and Future Directions
  • Acknowledgments

Chapter Seven: Neuronal Roles of the Bicaudal D Family of Motor Adaptors

  • Abstract
  • 1 Introduction
  • 2 The BICD Family of Cargo Adaptors
  • 3 Role of BicD in Drosophila Development
  • 4 Mammalian BICDs and Their Role in Mitotic Cells
  • 5 Role of BICD in Neurons
  • 6 BICDs and NT Signaling
  • 7 Conclusions
  • Acknowledgments

Chapter Eight: BDNF and Hippocampal Synaptic Plasticity

  • Abstract
  • 1 Introduction
  • 2 Basic Mechanisms of LTP
  • 3 The Neurotrophin Family and Its Receptors
  • 4 TrkB Localization and Signaling
  • 5 Synthesis and Secretion of BDNF
  • 6 BDNF and LTP in the Hippocampus
  • 7 p75NTR and LTD
  • 8 Interplay Between Glucocorticoids and BDNF to Determine Cellular Response to Stress
  • 9 Concluding Remarks

Chapter Nine: Neurotrophins in the Brain: Interaction With Alcohol Exposure During Development

  • Abstract
  • 1 Introduction
  • 2 Neurotrophins and the Developing Brain
  • 3 Alcohol as a Teratogenic Agent
  • 4 Neurotrophins as Targets of Alcohol Exposure
  • 5 Interactions Between Developmental Alcohol Exposure and Neurotrophins in the Brain: Molecular and Intracellular Effects
  • 6 Interactions Between Developmental Alcohol Exposure and Neurotrophins: Neuroanatomical and Behavioral Effects
  • 7 Neurotrophins as Compensatory/Neuroprotective Molecules Following Developmental Alcohol Exposure
  • 8 Conclusions
  • Acknowledgments

Chapter Ten: Neurotrophins: Role in Placental Growth and Development

  • Abstract
  • 1 Introduction
  • 2 Role of Neurotrophins in Placental Growth and Development
  • 3 Neurotrophins in Different Regions of the Placenta
  • 4 Cross Talk of Neurotrophins With Other Growth Factors and Proteases Involved in Placental Development
  • 5 Role of Neurotrophins in Pregnancy
  • 6 Conclusion and Future Directions
  • Acknowledgments

Chapter Eleven: Development of Precision Small-Molecule Proneurotrophic Therapies for Neurodegenerative Diseases

  • Abstract
  • 1 Introduction
  • 2 Mammalian Neurotrophin Ligand–Receptor System
  • 3 Neurotrophin Ligand–Receptor Biological Functionality
  • 4 Proneurotrophin-Based Therapy for Age-Related Neurodegeneration
  • 5 Future Developments in Small-Molecule Neurotrophic Agents

Chapter Twelve: The Role of Neurotrophins in Inflammation and Allergy

  • Abstract
  • 1 Introduction
  • 2 NTs and Allergic Disease
  • 3 NTs and Inflammatory Responses
  • 4 Conclusions

Chapter Thirteen: Neurotrophic Factors and Maternal Nutrition During Pregnancy

  • Abstract
  • 1 Introduction
  • 2 Neurotrophic Factors
  • 3 Maternal Nutrition
  • 4 Association Between Maternal Nutrition and Neurotrophic Factors Through One Carbon Cycle
  • 5 Consequences of Altered Maternal Nutrition in Pregnancy

Chapter Fourteen: The Role of Neurotrophin Signaling in Gliomagenesis: A Focus on the p75 Neurotrophin Receptor (p75NTR/CD271)

  • Abstract
  • 1 General Overview
  • 2 Malignant Glioma: A Major Clinical Challenge
  • 3 Glioma Disease Reservoirs
  • 4 Molecular Determinants of Glioma Invasion and Progression
  • 5 The Role of the Neurotrophins and Their Cognate Receptors in Glioma Progression
  • 6 A Role for p75NTR in Cancer: Extending Beyond Glioma
  • 7 Conclusions and Future Directions
  • Acknowledgments

Chapter Fifteen: Neurotrophic Factors Used to Treat Spinal Cord Injury

  • Abstract
  • 1 Introduction
  • 2 Neurotrophins
  • 3 Selected Examples of Other Growth Factors
  • 4 Combinations of Factors
  • 5 Location of Neurotrophic Factor Delivery
  • 6 Mode of Neurotrophic Factor Delivery
  • 7 Timing of Neurotrophic Factor Delivery
  • 8 Conclusion
  • Acknowledgments

Chapter Sixteen: Neurotrophins and Migraine

  • Abstract
  • 1 Introduction
  • 2 Neurotrophins and Pain
  • 3 Migraine Pathophysiology
  • 4 Neurotrophins and Migraine
  • 5 Conclusion and Future Directions

Chapter Seventeen: BDNF During Withdrawal

  • Abstract
  • 1 Introduction
  • 2 BDNF Alterations Following Chronic Administration of Drugs of Abuse
  • 3 Protracted Abstinence, Incubation, and Craving: How Is BDNF Involved?
  • 4 Peripheral BDNF Levels
  • 5 Polymorphism in BDNF Gene: Predictive Value in Drug Addiction?
  • 6 Conclusion and Future Directions
  • Acknowledgments

Chapter Eighteen: Neurotrophin Receptors and Perineural Invasion: Analyses in Select Lineage-Unrelated Cutaneous Malignancies With a Propensity for Perineural Invasion

  • Abstract
  • 1 Introduction
  • 2 PNI in Cancer
  • 3 Definitions
  • 4 Incidence of PNI in Cutaneous Malignancies
  • 5 Prognostic Impact of PNI in cSCC and DM
  • 6 The Biological Underpinnings of PNI: The Role of Neurotrophins
  • 7 Clinical Potential of Neurotrophins as Therapeutic Targets
  • 8 Personal Observations
  • 9 Conclusions

Description

Neurotrophins, the latest volume in the Vitamins and Hormones series first published in 1943, and the longest-running serial published by Academic Press, provides up-to-date information on crystal structures and basic structural studies on neurotrophins and their receptors, neurotrophin functions, and the biological actions of neurotrophins related to clinical conditions and disease. Each volume is thoroughly reviewed and focuses on a single molecule or disease that is related to vitamins or hormones, with the topic broadly interpreted to include related substances such as transmitters, cytokines, growth factors, and others.

Key Features

  • Provides cutting-edge reviews concerning the molecular and cellular biology of vitamins and hormones
  • Contains expertise from world-renowned contributors
  • Focuses on a single molecule or disease that is related to vitamins or hormones, with the topic broadly interpreted to include related substances such as transmitters, cytokines, growth factors, and others
  • Presents in-depth, current information from the molecular to clinical level

Readership

Researchers, faculty, and graduate students interested in cutting-edge reviews concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested


Details

No. of pages:
550
Copyright:
© Academic Press 2017
Published:
Imprint:
Academic Press
eBook ISBN:
9780128122648
Hardcover ISBN:
9780128122631

About the Serial Editors

Gerald Litwack Serial Editor

Dr. Litwack was formerly Professor of Molecular and Cellular Medicine and Associate Director at the Institute for Regenerative Medicine, Texas A & M Health Science Center.

Affiliations and Expertise

Toluca Lake, North Hollywood, CA, USA