Neurotrauma is the leading cause of death and disability in young adults, and the incidence in older patients is increasing. Neurotrauma is also a field in medicine with one of the highest unmet needs. Concentrated, focused and multidisciplinary efforts are required to combat this important disease. Exciting findings from basic research open opportunities for improving treatment results. This volume presents a unique and comprehensive overview of the latest findings and insights on translational research in neurotrauma. This book should be a must for any TBI or SCI researcher interested in translating their work to the clinic, as well as to clinicians interested in the latest research findings which could provide novel treatment strategies for their patients.

Key Features

Integrates results from research on traumatic brain injury and spinal cord injury, bridging basic science and clinical research Includes contributions from a worldwide panel of leading researchers and clinicians in the fields of TBI and SCI


Neuroscientists, neurobiologists, neurosurgeons, neuropathologists, neurologists, intensive care physicians.

Table of Contents

I. INTRODUCTION: 1. The impact of neurotrauma on society: an international perspective. II. BIOMECHANICS OF INJURY: 2. CNS injury biomechanics and experimental models 3. Linking impact to cellular and molecular sequelae of CNS injury: modelling in vivo complexity with in vitro simplicity III. PATHOLOGICAL MECHANISMS OF INJURY 4. Cellular and subcellular change evoked by diffuse traumatic brain injury – a complex web of change extending far beyond focal damage. 5. Astrologia: important mediators of traumatic brain injury. 6. Rescuing neurons and glia: is inhibition of apoptosis useful? 7. Substance P in traumatic brain injury. 8. Current concepts of cerebral oxygen transport and energy metabolism after severe traumatic brain injury. 9. Progressive damage after brain and spinal cord injury: pathomechanisms and treatment strategies. 10. Injury-induced alterations in CNS electrophysiology. 11. Traumatic injury of the spinal cord and nitric oxide. 12. Aquaporins: role in cerebral edema and brain water balance. 13. Sodium channel expression and the molecular pathophysiology of pain after SCI. IV. NOVEL ASPECTS OF CLINICAL RESEARCH IN CNS INJURY 14. Monitoring cerebral oxygenation in traumatic brain injury. 15. Update on the treatment of spinal cord injury. 16. Cerebral contusion: a role for lesion progression. 17. Ethical implications of time frames in a randomized controlled trial in acute severe traumatic brain injury. V. EMERGING TOPICS IN CNS TRAUMA 18. Experimental models of repetitive brain injuries. 19. Minor traumatic brain injury in sports: a review in order to prevent neurological sequelae. 20. Traumatic brain


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© 2007
Elsevier Science
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About the editors

John Weber

Affiliations and Expertise

Memorial University of Newfoundland, St. Johns, Canada