Neuropsychiatric Disorders and Epigenetics

Neuropsychiatric Disorders and Epigenetics

1st Edition - November 15, 2016

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  • Editors: Jacob Peedicayil, Dennis Grayson
  • eBook ISBN: 9780128005279
  • Hardcover ISBN: 9780128002261

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Neuropsychiatric Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addition to obesity contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant o disease. Recent discoveries in epigenetic research enabled by epic advances in genomic technologies have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders Neuropsychiatric disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with enormous costs to society. Thus, this volume will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development.

Key Features

  • Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction
  • Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists
  • Extensive use of diagrams, illustrations, tables, and graphical abstracts for each section providing rapid assessment


Graduate level doctoral students, medical students, clinicians, academic scientists, policy makers and applied scientists are the target audience for this volume. The work should appeal to those involved in genetic, biochemical, neuroscience, molecular biologic, pharmaceutical and psychiatric research

Table of Contents

  • Preface
    Dag H. Yasui, Jacob Peedicayil and Dennis R. Grayson

    Section I. Neuropsychiatric Disorders and Epigenetics: General Aspects
    1. Introduction to Neuropsychiatric Disorders and Epigenetics
    Dag H. Yasui, Jacob Peedicayil and Dennis R. Grayson

    2. Environmental Factors and Epigenetics of Neuropsychiatric Disorders
    Anke Hoffmann and Dietmar Spengler

    3. Epigenetic Biomarkers in Neuropsychiatric Disorders
    Chin-Chuen Lin, Tiao-Lai Huang

    Section II: Epigenetics of Neuropsychiatric Disorders
    4. Epigenetics and Cognitive Disorders -Translational Aspects
    Fabio Coppedè

    5. Epigenetics in Pervasive Developmental Disorders - Translational Aspects
    Takeo Kubota

    6. Epigenetic causes of intellectual disability – the fragile X syndrome paradigm
    Elisabetta Tabolacci, Giovanni Neri

    7. Epigenetics of Attention-Deficit Hyperactivity Disorder
    Nader Perroud, Sébastien Weibel, Jean-Michel Aubry, Alexandre Dayer

    8. The epigenetics of brain aging and psychiatric disorders
    Huan Gong, Xiangru Xu

    9. Epigenetic therapy may alleviate cognitive deficits in Down syndrome by downregulating overexpressed chromosome 21 gene products
    Alain D. Dekker, Peter P. De Deyn and Marianne G. Rots

    10. Epigenetics and Multiple Sclerosis
    Lara Kular, Gonçalo Castelo-Branco and Maja Jagodic

    11. Epigenetics and Migraine
    Siew Hua Gan and Munvar Miya Shaik

    12. The role of epigenetics in the pathophysiology of epilepsy
    Sung Min Nam and Kyung-Ok Cho

    13. Epigenetic Dysregulation in Brain Tumors and Neurodevelopment
    Marco M. Hefti and Nadejda Tsankova

    14. Epigenetics and Cerebrovascular Diseases
    Carolina Soriano-Tárraga, Jordi Jiménez-Conde and Jaume Roquer

    15. Epigenetics and Eating Disorders
    Helge Frieling, Vanessa Buchholz

    16. Epigenetics in Obesity
    Brian M. Shewchuk

    17. Epigenetics and Drug Addiction-Translational Aspects
    Jian Feng

    18. Epigenetics and Alcohol Use Disorders
    Sneha Sagarkar and Amul Sakharkar

    Section III: Summary and Outlook
    19. Summary and Outlook
    Dag H. Yasui, Jacob Peedicayil and Dennis R. Grayson

Product details

  • No. of pages: 444
  • Language: English
  • Copyright: © Academic Press 2016
  • Published: November 15, 2016
  • Imprint: Academic Press
  • eBook ISBN: 9780128005279
  • Hardcover ISBN: 9780128002261

About the Editors

Jacob Peedicayil

Dr Jacob Peedicayil completed MBBS in 1984 and MD in pharmacology in 1991, both at the Christian Medical College, Vellore, India. From 1993 to 1995 he did a Post-Doctoral Fellowship at the Centre for Cellular and Molecular Biology, Hyderabad, India. From 1995 to 1998 he worked as a Research Fellow in the Department of Neurological Sciences, Christian Medical College, Vellore. Since 1998 he has been on the faculty of the Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, becoming a professor in 2007. He does theoretical research on epigenetics, focusing on epigenetics in psychiatry. In addition, he is involved in experimental research in smooth muscle pharmacology.

Affiliations and Expertise

Professor, Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore

Dennis Grayson

Dr Dennis R. Grayson received his PhD from the Department of Biochemistry at Wayne State University School of Medicine in 1984. He has been interested in mechanisms associated with gene expression for over 35 years. He joined the laboratory of Dr James E. Darnell at the Rockefeller University as a Post-Doctoral Fellow in 1984 to study cell-type specific transcription factors and their interaction with promoters and enhancers. In 1988, Dr Grayson joined the Fidia-Georgetown Institute for the Neurosciences at Georgetown University to study gene expression programs in neurons and continued this research program at Allegheny Singer Research Institute in Pittsburgh from 1995 to 1998. He continued his interests in psychiatry and joined the Psychiatric Institute at the University of Illinois in 1998. This represented a unique opportunity to pursue the molecular underpinnings of schizophrenia. Dr Grayson has received NRSA post-doctoral support, and R01 and K04 funding from the National Institutes of Health to support his work. He has published over 140 papers in peer-reviewed journals and is regularly invited to speak at numerous national and international meetings. He is currently Director of the Epigenetic Core of the Center for Alcohol Research in Epigenetics.

Affiliations and Expertise

Professor of Molecular Neuroscience, University of Illinois at Chicago, IL, USA

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