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Neuroprotective Agents and Cerebral Ischaemia - 1st Edition - ISBN: 9780123668400, 9780080857749

Neuroprotective Agents and Cerebral Ischaemia, Volume 40

1st Edition

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Serial Editors: Ronald Bradley Robert Harris Peter Jenner
Serial Volume Editors: Richard Green Alan Cross
Hardcover ISBN: 9780123668400
eBook ISBN: 9780080857749
Imprint: Academic Press
Published Date: 26th November 1996
Page Count: 378
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Table of Contents

Mechanisms of Nerve Cell Death: Apoptosis or Necrosis after Cerebral Ischaemia, R.M.E. Chalmers-Redman, A.D. Fraser, W.Y.H. Ju, J. Wadia, N.A. Tatton, and W.G. Tatton. Changes in Ionic Fluxes during Cerebral Ischaemia, T. Kristián and B.K. Siesjö. Techniques for Examining Neuroprotective Drugs in Vivo, A.R. Green and A.J. Cross. Techniques for Assessing Neuroprotective Drugs in Vitro, M. P. Goldberg, U. Strasser and L.L. Dugan. Calcium Antagonists: Their Role in Neuroprotection, A.J. Hunter. Sodium and Potassium Channel Modulators: Their Role in Neuroprotection, T.P. Obrenovich. NMDA Antagonists: Their Role in Neuroprotection, D.L. Small and A.M. Buchan. Development of the NMDA Ion-Channel Blocker Aptiganel Hydrochloride as a Neuroprotective Agent for Acute CNS Injury, R.N. McBurney. Pharmacology of AMPA Antagonists and their Role in Neuroprotection, R. Gill and D. Lodge. GABA and Neuroprotection, P.D. Lyden. Adenosine and Neuroprotection, B.B. Fredholm. Interleukins and Cerebral Ischaemia, N.J. Rothwell, S.A. Loddick, and P. Stroemer. Nitrone-Based Free Radical Traps as Neuroprotective Agents in Cerebral Ischaemia and other Pathologies, K.Hensley, J.M. Carney, C.A. Stewart, T. Tabatabaie, Q. Pye, and R.A. Floyd. Neurotoxic and Neuroprotective Roles of Nitric Oxide in Cerebral Ischaemia, T. Dalkara and M.A. Moskowitz. A Review of Earlier Clinical Studies on Neuroprotective Agents and Current Approaches, N.G. Wahlgren. Index. Contents of Recent Volumes.


Since 1959, International Review of Neurobiology has been a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. This important serial is now being combined with Neuroscience Perspectives and Methods in Neurosciences. This combination results in a series that reaches a wider audience and publishes a greater number of thematic volumes.

Stroke is the third major cause of death in the western world, and recent data provide hope that treatments may soon be available. Written by world experts on the mechanisms involved in neurodegeneration, Neuroprotective Agents and Cerebral Ischaemia presents an up-to-date review of current research and developing therapies. This book is essential reading for all clinicians and researchers searching for neuroprotective drugs.

Key Features

  • Describes the mechanisms involved in cell death and the biochemical changes occurring during an ischaemic episode
  • Presents the different factors affecting the neurodegenerative process and how compounds acting on these systems may lead to novel neuroprotective agents
  • Reviews in vitro and in vivo models of stroke and the activity of putative neuroprotective drugs
  • Discusses the application of preclinical data to formulate approaches to a clinical problem
  • Provides detailed reviews of both completed clinical trials and those currently underway


Researchers, clinicians, and graduate students in neuroscience, cell genetics, pharmacology, biology, and physiology


No. of pages:
© Academic Press 1996
26th November 1996
Academic Press
Hardcover ISBN:
eBook ISBN:


"In balance, I recommend this book as a superior volume, whose high 'power-to-weight ratio,' readability, and availability in paperback make it attractive for personal use." --TRENDS IN NEUROSCIENCES

Ratings and Reviews

About the Serial Editors

Ronald Bradley

Affiliations and Expertise

Louisiana State University Medical Center, School of Medicine, Baton Rouge, U.S.A.

Robert Harris

Affiliations and Expertise

University of Texas, Austin, U.S.A.

Peter Jenner

Affiliations and Expertise

Division of Pharmacology and Therapeutics GKT School of Biomedical Sciences King’s College London SE1 1UL United Kingdom

About the Serial Volume Editors

Richard Green

Affiliations and Expertise

The Engineering Practice

Alan Cross

Alan Cross was at the MRC Clinical Research Centre, London, followed by two years as a lecturer in the Department of Physiology, University of Manchester. In 1980 he became Head of Pharmacology at the Aston Neuroscience Research Unit.

Affiliations and Expertise

Astra Arcus USA, Rochester, New York, U.S.A.