Neurophotonics and Biomedical Spectroscopy - 1st Edition - ISBN: 9780323480673

Neurophotonics and Biomedical Spectroscopy

1st Edition

Editors: R. R. Alfano Lingyan Shi
Hardcover ISBN: 9780323480673
Imprint: William Andrew
Published Date: 1st April 2018
Page Count: 400
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Table of Contents

Part 1: Topics in Optical Spectroscopy Biopsy
1. Origin of tissue optical properties
2. Optical methods for tissue diagnosis and treatment
3. Methods for in vivo assessment of physiological state of tissue
4. Excitation, absorption, scattering fluorescence spectroscopy
5. Resonance Raman spectroscopy
6. Inelastic light scattering spectroscopy and imaging
7. Stimulated Raman gain spectroscopy and imaging—NIR optical windows in 700 nm to 2500 nm
8. Coherent and non-contact photo-acoustic imaging
9. Polarization and diffusive reflectance spectral imaging time resolved spectroscopy single and multi photon excitation and imaging
10. Mid infrared diagnostic methods
11. Nano particle tagging and contrast agents optical metabolomics Demos , Gansean
12. Supercontinuum for medical and biological applications
13. Stokes shift spectroscopy

Part 2: Topics in Optics in Brain
14. Alzheimer’s Disease optical Imaging in vascular impairment
15. Hemodynamics by NIR in Brain, and Overview View summary of field
16. Blood Barrier in mice using two photon and ultrasound
17. Overview of Infrared neural stimulation
18. 2Photon excitation in brain
19. Overview NIR correlation spectroscopy in brain
20. Overview of Optical Coherent Tomography in neuron tree
21. IR stimulation in spinal nerves
22. Ca+2 channels in brain by multiphotons
23. Ca2+ flow in brain by multiphotons
24. Overview Ca2+ indicators by 2PEF
25. Control Biosystems using optogentics
26. Optogenetic circuit mapping with traditional whole cell patch clamp to determine synaptic connectivity between identified neurons in mouse models of psychiatric disease
27. Special Proteins Red fluorescent proteins RFP in brain probing(Dr. Robert Campbell)
28. OCT neural activity
29. Stimulated Raman Scattering Microscopy in Brain Research
30. Imaging the neurovascular coupling system with laminar optical tomography and hyperspectral two-photon microscopy
31. Multi photon Imaging in neuroscience


Description

Neurons, the basic building blocks of the nervous systems consist of billions in a tree-like structure which function and behavior forms the basis of understanding and manipulating neural activity. Direct stimulation on neural cells and tissues using electric, ultrasound and light has been tremendous interest and opportunity to alter brain function and Blood Brain Barrier (BBB). Infrared light can be used to stimulate neural activity in the peripheral and central nervous system. Light-based technologies with different wavelengths from the UV through the infrared have been applied to stimulate neural tissue and cells. The mechanism of light induced neural activation can be initiated. Novel optically inducible ion channels such as the opsins in optogentics for neural targeting, present an additional dimension to research.

Neurophotonics and Biomedical Spectroscopy addresses these issues in two parts:

Part 1 presents the novel state-of-the-art work in non-invasive optical spectroscopic methods to detect the onset and progression of diseases, including pre-malignancy , cancer ,and Alzheimer’s disease, and tissue and cell response to external conditions such as therapeutic intervention, unintended injury, and laser energy deposition.

Part 2 highlights research in neurophotonics that investigates single and multi-photon excitation optical signatures of normal/ diseased nerve tissues and brain, for better understanding the underlying biochemical and structural changes of tissues and cells that are responsible for the observed spectroscopic signatures.

The topics cover a wide array of well-established UV, visible, NIR and IR optical and spectroscopic techniques and novel approaches to diagnose tissue changes, including: label free in vivo and ex vivo fluorescence spectroscopy, Stoke shift spectroscopy, spectral imaging, Resonance Raman spectroscopy, multiphoton two Photon excitation , second harmonic, third harmonic and NIR photonic imaging methods, to detect tissue or body fluids properties and functions implemented in vivo or ex vivo covering the technology development from bench-to-bedside.

Key Features

  • Provides an overview of the spectroscopic properties of tissue and tissue-light interaction, describing techniques to exploit these properties in imaging
  • Explores the potential and significance of molecule-specific imaging, and its capacity to reveal vital new information on nanoscale structures
  • Offers a concise overview of different spectroscopic methods and their potential benefits for solving diagnostic and therapeutic problems

Readership

Researchers in nanomedicine, nanophotonics and optics, biomedical optics, neuroscientists, molecular biologists, clinical neurologists, and optical physics


Details

No. of pages:
400
Language:
English
Copyright:
© William Andrew 2018
Published:
Imprint:
William Andrew
Hardcover ISBN:
9780323480673

About the Editors

R. R. Alfano Editor

Robert A. Alfano is Distinguished Professor and Fellow at The City College of City University of New York, USA. He is also an Optical Society of America; Fellow, and a Fellow of IEEE. He has been involved in developing ultrafast laser spectroscopic techniques and applications of these techniques to study ultrafast dynamical processes in physical, chemical, and biological systems. His research encompasses the study and development of supercontinuum, tunable solid-state lasers, nonlinear optical processes, application of optical spectroscopic techniques for medical diagnosis (optical biopsy), study of photon migration in turbid media, and development of optical imaging techniques for biomedical imaging (optical mammography). He has published more than 700 papers and holds 102 patents.

Affiliations and Expertise

Professor and Fellow, The City College of City University of New York, USA

Lingyan Shi Editor

Lingyan Shi is a Research Associate at the Institute of Ultrafast Laser Spectroscopy, and Department of Biology, The City College of City University of New York, USA. His research interests include microscopic transport modelling ,cardiovascular biomechanics and drug delivery, blood-brain barrier (BBB) and its permeability, biomedical optics/biophotonics, multiphoton imaging, and neuronal-vascular coupling and development.

Affiliations and Expertise

Research Associate, Institute of Ultrafast Laser Spectroscopy and Department of Biology, The City College of City University of New York, USA