Neuropeptide Y and Drug Development

Neuropeptide Y and Drug Development

1st Edition - November 15, 1996

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  • Editors: Lars Grundemar, Stephen Bloom
  • Hardcover ISBN: 9780123049902
  • eBook ISBN: 9780080537450

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Neuropeptide Y (NPY) is a ubiquitous and important messenger in the nervous system, with a wide range of physiological roles. It is involved in the body energy balance and is one of the most potent stimuli of food intake known. NPY also acts to regulate central and peripheral autonomic functions. This book, written by academic and industrial experts in the field, links the most recent basic experimental knowledge about NPY and its receptors with areas of clinical importance. This book will be of interest to those working in all areas of research affected by NPY, such as food intake and energy homeostasis, cardiovascular regulation and G-protein-coupled receptors, as well as those interested in the development of drugs as NPY targets.

Key Features

  • The hypothalamic role of NPY and its relationship with eating disorders and diabetes
  • The sympathetic nervous system role of NPY and its involvement in cardiovascular disorders
  • Characterization of NPY receptor types and their brain distribution, molecular biology and pharmacology
  • Development of peptide and non-peptide receptor antagonists

Table of Contents

  • Multiple Receptors and Multiple Actions
    Central Effects of Neuropeptide Y and Its Role in Obesity and Diabetes
    Neuropeptide Y in Sympathetic Nerves-Evidence for Y1 Receptor-Mediated Vascular Control
    Neuropeptide Y Receptor Types in Mammalian Brain
    Species Differences and Status in the Human Central Nervous System
    Extraordinary Structural Diversity of Neuropeptide Y Family Receptors
    The Importance of Various Parts of the Neuropeptide Y Molecule for Receptor Recognition
    Peptide Antagonists of Neuropeptide Y: Design, Structure, And Pharmacological Characterization
    SR 120819A or the First Generation of Orally-Active Neuropeptide Y1 Receptor Antagonists
    BIBP3226, A Potent and Selective Y1 Receptor Antagonist
    First Structure-Activity Studies and Localization of the Human Y1 Receptor Binding Site
    Discovery of Neuropeptide Y Receptor Antagonists

Product details

  • No. of pages: 209
  • Language: English
  • Copyright: © Academic Press 1996
  • Published: November 15, 1996
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123049902
  • eBook ISBN: 9780080537450

About the Editors

Lars Grundemar

Affiliations and Expertise

Dept of Clinical Pharmacology, Lund University Hospital, Sweden

Stephen Bloom

Affiliations and Expertise

Royal Postgraduate Medical School, University of London, Hammersmith Hospital, U.K.

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