Neuropeptide Analogs, Conjugates, and Fragments - 1st Edition - ISBN: 9780121852757, 9781483217536

Neuropeptide Analogs, Conjugates, and Fragments

1st Edition

Methods in Neurosciences, Vol. 13

Editors: P. Michael Conn
eBook ISBN: 9781483217536
Imprint: Academic Press
Published Date: 11th May 1993
Page Count: 414
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Description

Methods in Neurosciences, Volume 13: Neuropeptide Analogs, Conjugates, and Fragments covers the synthesis and characterization of peptide analogs, conjugates, and fragments, their use as ligands for receptors, and their role in the development and use of antisera. The book discusses techniques such as novel synthetic approaches; biotinylation; purification and characterization; radioligand techniques and assay development; use of agonists and antagonists; distinguishing receptor subtypes; conjugation to carrier proteins; antiidiotypic antibody development; and radiolabeling. Neuroscientists, biochemists, neurochemists, and pharmacologists will find the book useful.

Table of Contents


Contributors to Volume 13

Preface

Volumes in Series

Section I Synthesis and Characterization

1. Synthetic Approaches to Incorporation of Novel Amino Acids into Gonadotropin-Releasing Hormone Peptides

2. Synthesis of Pseudopeptides

3. Synthesis and Synthetic Manipulations of Peptides Derived from Parathyroid Hormone and Parathyroid Hormone-Related Protein

4. Biotinylated Neuropeptide Analogs: Design and Use as Probes for Target Cells in Heterogeneous Populations

5. Peptide Characterization and Purification Using High-Performance Liquid Chromatography

Section II Development and Use of Receptor Ligands

6. Atrial Natriuretic Factors and Fragments

7. Atrial Natriuretic Factor Binding to Clearance Receptors in Isolated Neuronal Membranes

8. Biotinylated Endothelin Analogs as Probes for Endothelin Receptor

9. Analogs of Endothelin

10. Selective Cholecystokinin A and Cholecystokinin B/Gastrin Receptor Agonists

11. Tachykinin Receptor Antagonists

12. Somatostatin Receptor Subtypes in Rat Brain Revealed by Somatostatin Analogs

13. Thyrotropin-Releasing Hormone: Analogs and Receptors

14. Distinguishing Bombesin Receptor Subtypes

15. Bombesin Receptor Subtypes: Characterization and Solubilization

16. Nonpeptide Angiotensin II Receptor Antagonist: Losartan

17. Via Vasopressin Receptors: Selective Biotinylated Probes

18. Via Vasopressin Receptors: Studies with Radioiodinated Ligand

19. Pharmacological Identification of Vasopressin Receptors in Isolated Renal Tubule

Section III Development and Use of Antisera

20. Neuropeptide Conjugation to Carrier Protein

21. Antiidiotypic Thyrotropin-Releasing Hormone Antibody

22. 125I-Labeled Substance P: Influence of Oxidation State on Sensitivity of Radioimmunoassay

Index


Details

No. of pages:
414
Language:
English
Copyright:
© Academic Press 1993
Published:
Imprint:
Academic Press
eBook ISBN:
9781483217536

About the Editor

P. Michael Conn

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. Conn is a previous member of Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation and worked with political leadership to heighten the public’s awareness of diabetes. Conn’s students and fellows have gone on to become leaders in industry and academia. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science. He is the co-author of The Animal Research War (2008) and many articles for the public and academic community on the value of animal research and the dangers posed by animal extremism. His op/eds have appeared in The Washington Post, The LA Times, The Wall Street Journal, the Des Moines Register, and elsewhere. Conn consults with organizations that are influenced by animal extremism and with universities and companies facing challenges from these groups.

Affiliations and Expertise

Texas Tech University Health Sciences Center, Lubbock, USA