Neurons and astrocytes have an intimate anatomic and functional realtionship and are heavily dependent on each other. This intensive relationship is virtually important not only in normal CNS function, but also in disease states. Research to better define and underatand this relationship will lay the foundation for rational new therapies for disorders of the CNS.

The chapters in this volume have been written by scientists and physicians from around the world. To have optimum diversity of approach, the volume discusses basic research as well as clinical experience regarding the interactions of neurons and astrocytes in both normal and pathological conditions.

Table of Contents

1. A century of neuronal and neuroglial interactions, and their pathological implications; an overview. 2. The brain as a chemical machine. Ion Homeostasis 3. Intracellular pH regulation in mammalian astrocytes. 4. Role of astrocytes in ionic and volume homeostasis in spinal cord during development and injury. 5. Functional consequences of astrocytic swelling. 6. Swelling of C6 glioma cells and astrocytes from glutamate, high K+concentrations, or acidosis. 7. Pharmacological regulation of astrocytic ion channels: Implications for the treatment of seizure disorders. 8. The expression of sodium channels in astrocytes in situ and in vitro. 9. Ion involvement in memory formation: the potential role of astrocytes. Calcium, Signalling and Gene Expression 10. Do astrocytes process informations? 11. Distribution of calcium in ischemic brain of gerbils. 12. Signalling by extracellular ATP: physiological and pathological considerations in neuronal-astrocytic interactions. 13. The role of polyphosphoinositides in agonist-evoked release of vasoactive factors from astrocytes. 14. Isolation of transcriptionally regulated sequences associated with neuronal and non-neuronal cell interactions. 15. Early response gene induction in astrocytes as a mechanism for encoding and integrating neuronal signals. 16. c-Fos induction occurs in cultured cortical neurons and astrocytes via multiple signalling pathways Glutamate: Metabolism and Toxicity 17. Regulatory role of astrocytes for neuronal biosynthesis and homeostasis of glutamate and GABA. 18. Nitrogen metabolism: neuronal-astroglial relationships. 19. Ultrastructural immunocytochemical observations on the localization, metabolism, and transport of glutamate in normal and ischemic brain tissue. 20. Release of exogenous and endogenous neurotransmitter amino acids from cultured astrocytes. 21. Glutamate as an energy substrate for neuronal-astrocytic interactio


© 1992
Elsevier Science
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