Neuromuscular Junctions in Drosophila

Neuromuscular Junctions in Drosophila

1st Edition - April 6, 1999

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  • Editors: Vivian Budnik, L. Gramates
  • eBook ISBN: 9780080857770

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Neuromuscular Junctions in Drosophila gathers the main contributions that research using the fruit fly Drosophila melanogaster has made in the area of synapse development, synapse physiology, and excitability of muscles and nerve cells. The chapters in this book represent a synthesis of major advances in our understanding of neuronal development and synaptic physiology, which have been obtained using the above approach.This book is directed to the general neuroscience audience: researchers, instructors, graduate students, and advanced undergraduates who are interested in the mechanisms of synapse development and physiology. However, the book will also be a valuable resource for those that use the fruit fly as a model system in their laboratories.

Key Features

@introbul:Key Features
@bul:* Synthesizes the genetic approaches used to study synaptic development and function at the neuromuscular junction, using flies as a model system
* Covers major recent advances in muscle development, pathfinding, synapse maturation and plasticity, exo- and endocytosis, and ion channel function
* Written in clear language that is easily understandable to readers not already familiar with fruit fly research
* Includes numerous diagrams and extensive reference lists


Graduate students, post-docs, and researchers in neuroscience, developmental biology, cell biology, and molecular biology.

Table of Contents

  • V. Budnik and L.S. Gramates, Preface.
    A. Chiba, Early Development of the Drosophila Neuromuscular Junction: A Model for Studying Neuronal Networks in Development.
    M. Bate, M. Landgraf, and M.R. Gómez Bate, Development of Larval Body Wall Muscles.
    M.B. Rheuben, M. Yoshihara, and Y. Kidokoro, Ultrastructural Correlates of Neuromuscular Junction Development.
    L.S. Gramates and V. Budnik, Assembly and Maturation of the Drosophila Larval Neuromuscular Junction.
    F. Hannan and Y. Zhong, Second Messenger Systems Underlying Plasticity at the Neuromuscular Junction.
    J.T. Littleton, L. Pallanck, and B. Genetzky, Mechanisms of Neurotransmitter Release.
    D.T. Stimson and M. Ramaswami, Vesicle Recycling at the DrosophilaNeuromuscular Junction.
    S. Singh and C.-F. Wu, Ionic Currents in the Larval Muscles of Drosophila.
    J.R. Trimarchi, P. Jin, and R.K. Murphey, Controlling the Motor Neuron.
    Chapter References.
    Contents of Recent Volumes.

Product details

  • No. of pages: 289
  • Language: English
  • Copyright: © Academic Press 1999
  • Published: April 6, 1999
  • Imprint: Academic Press
  • eBook ISBN: 9780080857770

About the Serial Volume Editors

Vivian Budnik

Affiliations and Expertise

University of Massachusetts, Amherst, U.S.A.

L. Gramates

Affiliations and Expertise

University of Massachusetts, Amherst, U.S.A.

About the Serial Editors

Ronald Bradley

Affiliations and Expertise

Louisiana State University Medical Center, School of Medicine, Baton Rouge, U.S.A.

Robert Harris

Affiliations and Expertise

University of Texas, Austin, U.S.A.

Peter Jenner

Professor Peter Jenner is a specialist in preclinical aspects of neurodegenerative diseases, notably Parkinson’s disease. He has spent the major part of his career at King’s College London where he was Head of Pharmacology for 14 years before returning to his research roots and subsequently becoming Emeritus Professor of Pharmacology. Peter has expertise in drug metabolism and pharmacokinetics but neuropharmacology based on functional models of neurodegenerative diseases has formed the major focus of his work. Peter holds a BPharm, PhD and DSc degree from the University of London. He has published well over 1000 articles with more than 700 peer reviewed papers. He is a Fellow of the Royal Pharmaceutical Society, the British Pharmacological Society, the Royal Society of Medicine and of King’s College London. Peter was recently honoured with a Doctor Honoris Causa degree from Carol Davila University of Medicine and Pharmacy, Bucharest and made an Honorary Fellow of The British Pharmacological Society for his contribution to research in to movement disorders. Peter has worked closely with the pharmaceutical industry for many years and acts as an adviser and consultant to both major pharma and biotech companies. He has a wide knowledge of the drug discovery and drug development process and has been involved from molecule synthesis through to drug registration for use in man. Peter was the Founder, Director and Chief Scientific Officer of Proximagen, a biotech focussed on the treatment and cure of neurodegenerative diseases that was listed on AIMs and subsequently purchased by a US based healthcare company. He is a regular speaker at international meetings and also takes time to speak at Parkinson’s disease patient-carer groups across the UK.

Affiliations and Expertise

Emeritus Professor of Pharmacology, Institute of Pharmaceutical Sciences, King’s College London, London, UK

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