Neuromuscular Function and Disorders

Neuromuscular Function and Disorders

1st Edition - March 17, 1977

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  • Author: Alan J. McComas
  • eBook ISBN: 9781483163062

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Neuromuscular Function and Disorders focuses on the various processes underlying disordered neuromuscular function. Topics covered include the nature of membrane defects in myotonia and familial periodic paralysis; the disorder of neuromuscular transmission responsible for myasthenia gravis and the various pseudo-myasthenic syndromes; and the disorders of Schwann cell function which cause demyelination. This book is comprised of 28 chapters divided into two sections and begins with a discussion on the normal anatomy and physiology of peripheral nerve and muscle. Included in the first section are descriptions of the ionic mechanisms responsible for the resting and action potentials of nerve and muscle; the sequential stages in neuromuscular transmission; excitation-contraction coupling; the sliding filament mechanism of myofibrillar shortening; and the morphological and functional properties of motor units. The neurophysiology of exercise and muscle fatigue is also considered, along with the nature of the trophic influences exerted by the motoneuron and muscle fiber upon each other. The second half of the book deals entirely with various diseases of peripheral nerve and muscle, together with diagnostic procedures and therapeutic management. A consistent theme in this section is the recognition of neural abnormalities in diseases hitherto considered as primary disorders of the muscle fiber. This monograph should be of value to neurologists, medical students, research workers, and students and research scientists in physiology, zoology, pharmacology, kinesiology, and physical education.

Table of Contents

  • Part 1: Muscle Fibers and Motoneurones

    1 The Muscle Fiber

    2 The Motoneurone and its Axon

    3 Resting and Action Potentials

    4 The Neuromuscular Junction

    5 Muscle Contraction

    6 Motor Units

    7 Exercise and Fatigue

    8 Trophic Interactions of Nerve and Muscle: Denervation and Reinnervation

    9 Use and Disuse

    10 Trophic Influence of Muscle on Nerve

    11 Muscle Growth

    12 Aging

    Part 2: Disorders of Muscle and Nerve

    13 Neuropathic and Myopathic Disorders: Sick Motoneurone Hypothesis

    Disorders of Muscle Fiber Membranes

    14 Myotonia

    15 Familial Periodic Paralysis

    Disorders of Muscle Fiber Contents

    16 The Muscular Dystrophies

    17 Polymyositis, Malignant Hyperthermia and Other Myopathies

    Disorders of Neuromuscular Junctions

    18 Myasthenia Gravis

    19 Pseudomyasthenic Syndromes and Other Synaptic Defects

    Disorders of Nerve Fibers

    20 Wallerian Degeneration and Fiber Regeneration

    21 Demyelination and Remyelination

    22 Nerve Compression

    23 The Double Crush Syndrome

    Disorders of Motoneurones

    24 Motoneurone Degeneration

    25 Toxic and Metabolic Neuropathies

    26 Reversible Motoneurone Dysfunction in Thyrotoxicosis

    27 Trans-synaptic Motoneurone Degeneration

    28 Conclusions




Product details

  • No. of pages: 374
  • Language: English
  • Copyright: © Butterworth-Heinemann 1977
  • Published: March 17, 1977
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483163062

About the Author

Alan J. McComas

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