Neuromodulation

Neuromodulation

Comprehensive Textbook of Principles, Technologies, and Therapies

2nd Edition - January 5, 2018

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  • Editors: Elliot Krames, P. Hunter Peckham, Ali Rezai
  • Hardcover ISBN: 9780128053539
  • eBook ISBN: 9780128093023

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Description

Neuromodulation: Comprehensive Textbook of Principles, Technologies, and Therapies, Second Edition, serves as a comprehensive and in-depth reference textbook covering all aspects of the rapidly growing field of neuromodulation. Since the publication of the first edition seven years ago, there has been an explosion of knowledge in neuromodulation, optogenetics, bioelectronics medicine and brain computer interfacing. Users will find unique discussions of the fundamental principles of neuromodulation and therapies, and how they are applied to the brain, spinal cord, peripheral nerves, autonomic nerves and various organs. The book focuses on comprehensive coverage of spinal cord stimulation, non-interventional and interventional brain stimulation, peripheral nerve stimulation, and the emerging fields of neuromodulation, including optogenetics and bioelectronics medicine.

Key Features

  • Provides a comprehensive reference that covers all aspects of the growing field of neuromodulation
  • Written by international, leading authorities in their respective fields of neuromodulation, pain management, functional neurosurgery and biomedical engineering
  • Includes new chapters on optogenetics, bioelectronics medicine and brain computer interfacing

Readership

Advanced graduate students, researchers, and clinicians in the fields of neuroscience, neurology, neurosurgery, psychiatry, and biomedical engineering

Table of Contents

  • Volume 1:
    SECTION I: Defining Neuromodulation
    1. Perspectives on the History of the Neuromodulation Societies
    2. Psychological Issues and Evaluation for Patients Undergoing Implantable Technology
    3. Relevant Anatomy of the Nervous System to Neuromodulation (central, peripheral, autonomic-Vagus)
    4. Clinical Study Designs for Neuromodulation

    SECTION II: The Brain Initiative—Implications for a Revolutionary Change in Clinical Medicine via Neuromodulation Technology
    5. The Brain Initiative—Implications for a Revolutionary Change in Clinical Medicine via Neuromodulation Technology

    SECTION III: FUNDAMENTALS AND MECHANISMS OF NEUROMODULATION 
    6. Fundamentals of Electrical Stimulation  
    7. The Safe Delivery of Electrical Currents and Neuromodulation
    8. The Role of Wave Forms for Electrical Stimulation of the Nervous System
    9. Neuromodulation and Neuronal Plasticity
    10. Fundamentals of High Frequency Nerve Conduction Block of the Peripheral Nervous System
    11. MRI and fMRI for Neuromodulation  Vibhor Krishna
    12. Computational Modeling of Deep Brain Stimulation
    13. Computational Modeling of Deep Brain Stimulation – Neurotargeting
    14. Fundamentals of Burst Stimulation of the Spinal Cord and Brain
    15. Mechanisms of Action of Spinal Cord Stimulation for Pain (Traditional, Dorsal Root Spinal Stimulation, kHz frequency stimulation
    16. Fundamentals and Mechanisms of Dorsal Root Ganglion (DRG) Stimulation  
    17. Mechanisms of Action of Deep Brain Stimulation
    18. Mechanisms of Action of Vagal Nerve Stimulation
    19. Mechanisms of Action of Sacral Nerve Stimulation for Disorders of Bladder and bowel

    SECTION IV:  TECHNOLOGY AND DEVICES
    20. Electrodes for Recording and Stimulating the Peripheral Neural Interface
    21. Implantable Neural Stimulators: Powering, Control and Packaging
    22. Microstimulators
    23. Designing Neuromodulation Systems For Feedback Control
    24. MRI Safety and Neuromodulation Systems

    SECTION V: BRAIN, COMPUTER AND MACHINE INTERFACING
    25. Brain Computer Interfaces: Why Not Better?
    26. Non-Invasive BCI 
    27. Invasive BCI
    28. Prospects for a robust cortical recording interface
    29. Brain Machine Interfacing—Signal Processing, and extraction of signals

    SECTION VI: EMERGING TECHNOLOGIES AND TECHNIQUES
    30. Gene-Based Neuromodulation
    31. Focused Ultrasound
    32. Implanted Sensors in Neuromodulation via Electrical Stimulation
    33. Neurogaming
    34. The Use of New Surgical Technologies for Deep Brain Stimulation (ultrasound, atlases, MRI)
    35. Neuromodulation Using Optogenetics and Related Technologies

    SECTION VII:  SURGICAL PROCEDURES AND TECHNIQUES
    36. Deep Brain Stimulation: Surgical Technique
    37. Spinal Cord Stimulation: Placement of Surgical Leads via Laminotomy Techniques and Benefits
    38. Subcutaneous Peripheral Nerve Field Stimulation for Intractable Pain 
    39. Surgical Placement of Leads for Occipital Nerve Stimulation
    40. Intrathecal Medication Delivery System Implantation
    41. Neuroprosthetic Surgical Strategies for Neuromuscular Stimulation
    42. The Surgical Technique of Vagus Nerve Stimulator Implantation


    VOLUME 2
    SECTION VIII:  NEUROMODULATION FOR PAIN CONTROL
    SECTION VIII A: SPINAL CORD STIMULATION FOR PAIN CONTROL
    43. Physiology and Pathophysiology of Chronic Pain
    44. Management Strategies for Chronic Pain
    45. History of Spinal Cord Stimulation  
    46. Functional Magnetic Resonance Imaging in the Neuromodulation of Pain 
    47. The Development of Algorithms for Pain Care including Neuromodulation Therapies: Introducing the SAFE Principle 
    48. Neurostimulation for the Treatment of Complex Regional Pain Syndrome
    49. Spinal Cord Stimulation for Peripheral Neuropathic Pain
    50. Spinal Cord Stimulation for the Treatment of Low Back Pain
    51. Spinal Cord Stimulations: Complications and Management 
    52. Clinical Aspects of Burst stimulation for Pain Control
    53. DRG stimulation for Pain Control
    54. High Frequency Stimulation of the Spinal Cord for Pain Control
    55. A Review of Spinal Cord Stimulation Cost Studies  

    SECTION VIII B:   PERIPHERAL NERVE STIMULATION FOR PAIN CONTROL INTRODUCTION: PERIPHERAL NERVE STIMULATION FOR PAIN CONTROL
    56. Anatomy and Physiology Related to Peripheral Nerve Stimulation
    57. Peripheral Nerve Stimulation for Pain Suppression
    58. Peripheral Nerve Stimulation for Facial Pain
    59. Combined Spinal Cord Stimulation and Peripheral Field Stimulation for the Treatment of Chronic Back and Neck Pain
    60. Percutaneous Peripheral Nerve Stimulation for the Management of Acute Post-Operative Pain
    61. Peripheral Nerve Field Stimulation for intractable pain
    62. Occipital Neurostimulation for Treatment of Intractable Headache Syndromes
    63. Neurostimulation for Headaches—Sphenopalatine Ganglion Stimulation

    SECTION VIII C:  INTRATHECAL THERAPIES FOR PAIN CONTROL AND THE CONTROL OF SPASTICITY
    64. Relevant Anatomy for Spinal Delivery
    65. Evolution of the Spinal Delivery of Opiate Analgesics
    66. Pharmacology of Intrathecal Therapy 
    67. Cerebrospinal Fluid Dynamics and Intrathecal Delivery
    68. Exploring Non-Opioid Analgesic Agents for Intrathecal Use
    69. New Molecules for Intrathecal Delivery for Pain Control
    70. The Development of Guidelines for Intrathecal Therapies for Pain Control:  History and Present Guidelines
    71. Compounding Intrathecal Analgesic Agents
    72. Intrathecal Baclofen for Control of Spasticity

    SECTION VIII D:  INTRACRANIAL PROCEDURES FOR CHRONIC PAIN
    73. Deep Brain Stimulation for Pain

    SECTION IX: NEUROMODULATION FOR MOVEMENT DISORDERS
    74. Deep Brain Stimulation for Parkinson’s Disease
    75. Deep Brain Stimulation for Tremor 
    76. Deep Brain Stimulation for Torsion Dystonia
    77. Deep Brain Stimulation for Tourette Syndrome
    78. Surgical Management of Hemifacial Spasm and Meige Syndrome
    79. Deep Brain Stimulation of the Pedunculopontine Tegmental Nucleus improves static balance in Parkinson’s Disease
    80. Infusion Therapy for Movement Disorders

    SECTION X: NEUROSTIMULATION FOR EPILEPSY
    81. Epilepsy: Anatomy, Physiology, Pathophysiology, and Disorders
    82. Vagus Nerve Stimulation for Epilepsy
    83. Deep Brain Stimulation for Epilepsy  
    84. Closed loop Responsive stimulation for Epilepsy

    SECTION XI: NEUROMODULATION FOR BEHAVIORAL AND COGNITIVE DISORDERS
    85. Electrical Brain Stimulation for Treatment-Resistant Obsessive–Compulsive Disorder
    86. High-Intensity Focused Ultrasound Surgery for the Treatment of Obsessive-Compulsive Disorder
    87. Deep Brain Stimulation for Highly Refractory Depression
    88. Neuromodulation for Anorexia
    89. Deep Brain Stimulation for Alcoholism  
    90. Surgical Treatment for Refractory Drug Addictions
    91. Subgenual Cingulate Deep Brain Stimulation for Treatment-Resistant Depression
    92. Cortical Stimulation for Depression


    VOLUME 3
    SECTION XII:  NEUROMODULATION FOR FUNCTIONAL RESTORATION
    93. The History of Neuromuscular Electrical Stimulation
    94. Stimulation for Return of Function after Stroke
    95. Invasive Neurostimulation for Post Stroke Motor Recovery
    96. Stimulation for Return of Upper Extremity Function
    97. Lower Extgremity Motor System Neuroprostheses
    98. Neuromodulation of the Spinal Cord for Movement Restoration
    99. A brief history of the cochlear implant and related treatments
    100. Stimulation for the Return of Hearing 
    101. The Development of Visual Prosthetic Devices to Restore Vision to the Blind  
    102. Neuromodulation for Treatment of Dry Eye
    103. Restoration of Tactile Sensation  Dustin Tyler

    SECTION XIII:  NEUROMODULATION FOR ORGAN SYSTEMS
    SECTION XIII A:  NEUROMODULATION FOR CARDIOVASCULAR DISORDERS
    104. Autonomic control of the heart
    105. Spinal Cord Stimulation for Peripheral Vascular Disorders
    106. Neuromodulation for Refractory Angina and Heart Failure
    107. Baroreceptor activation for hypertension and heart failure

    SECTION XIII B:  NEUROMODULATION FOR PULMONARY DISORDERS
    108. Upper Airway Neurostimulation to Treat Obstructive Sleep Apnea
    109. A Neural Prosthesis for Obstructive Sleep Apnea
    110. Transvenous phrenic nerve stimulation for central sleep Apnea
    111. Neurostimulation for Asthma
    112. Stimulation for Inspiration
    113. Stimulation for Cough

    SECTION XIII C:  NEUROMODULATION FOR GASTROINTESTINAL DISORDERS
    114. Neural Control of the GI System 
    115. Spinal Cord Stimulation for Gastrointestinal Painful Disorders 
    116. Emerging Gastric Stimulation for Dysmotility Disorders and Obesity
    117. Intestinal Electrical Stimulation: Methodologies, Effects, Mechanisms, and Applications
    118. Neuromodulation for nausea and vomiting in adult patients
    119. Neuromodulation for GI Dysmotility in pediatric patients
    120. Colonic electrical stimulation for constipation

    SECTION XIII D:  NEUROMODULATION FOR UROGENITAL DISORDERS
    121. Neurophysiology and Neuroanatomy of the Genitourinary Organs
    122. Sacral Nerve Stimulation
    123. Sacral Nerve Root Stimulation for Painful Bladder Syndrome/Interstitial Cystitis
    124. Restoration of Urinary and Bowel Control

    SECTION XIV:  Neuromodulation for endocrine, immune, and inflammatory disorders
    125. Vagal nerve stimulation and control of anti-inflammatory pathways
    126. Activation of the Inflammatory Reflex in Rheumatoid Arthritis and Inflammatory Bowel Disease; Preclinical Evidence 
    127. Bioelectronic Therapy for the Treatment of Rheumatoid Arthritis and Inflammatory Bowel Disease
    128. Vagal Nerve Stimulation versus Sacral Nerve Stimulation for Control of Inflammation
    129. Autonomic regulation therapy (ART) for disorders of the heart
    130. The Neural Tourniquet
    131. Neural decoding for diagnostics and restoration of motor function
    132. The Role of Vagus Nerve Stimulation for the Treatment of Central and Peripheral Pain Disorders and Related Co-morbid Somatoform Conditions
    133. Insulin Resistance, Glucose Metabolism, Inflammation and the Role of Neuromodulation as a Therapy for Type-2 Diabetes

    SECTION XV:  NON INVASIVE NEUROMODULATION
    134. Transcranial Magnetic Stimulation 
    135. Transcranial Direct Current Stimulation
    136. Transcranial Pulse Current Stimulation
    137. Novel Methods of Transcranial Stimulation: Electrosonic Stimulation
    138. Optimization of Non-Invasive Brain Stimulation
    139. Transcranial Direct Current Stimulation for Fatigue and Attentional Disorders

    SECTION XVI: THE BUSINESS END OF NEUROMODULATION
    140. Challenges in Moving Toward Product Development: from the Perspective of Neuromodulation Companies
    141. Neuromodulation, the field from an industry perspective in 2016
    142. Neuromodulation: Regulatory Considerations
    143. Reimbursement for neuromodulation therapies and technologies
    144. Perspectives on How to Build a Neuromodulation Practice

Product details

  • No. of pages: 1828
  • Language: English
  • Copyright: © Academic Press 2018
  • Published: January 5, 2018
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128053539
  • eBook ISBN: 9780128093023

About the Editors

Elliot Krames

Elliot S. Krames, MD, is a board-certified anesthesiologist who has been practicing pain medicine solely since 1987. He is a worldwide-recognized leader and educator in the field of neuromodulation for pain control. He has written extensively on implantable technologies for pain management and has conducted national and international symposia related to this topic. He is co-founder of the National Pain Foundation, a founding member of the North American Neuromodulation Society and has participated on the boards of the North American Neuromodulation Society, the International Neuromodulation Society, the World Institute of Pain, the American Academy of Pain Medicine, and the American Board of Pain Medicine. Dr. Krames has published more than 100 research papers, serves on several editorial boards, and co-edited a number of books. Dr. Krames was the founding editor of Neuromodulation: Technology at the Neural Interface, the journal of the International Neuromodulation Society, serving as Editor-in-Chief from 1998 until September 2009, when he became Emeritus Editor-in-Chief. Dr. Krames served as INS President from 2006 to 2009, as immediate Past President from 2009 to 2011, and since 2011 has been Emeritus Director-at-Large.

Affiliations and Expertise

Pacific Pain Treatment Center, San Francisco, CA, USA

P. Hunter Peckham

Dr. Peckham is the Donnell Institute Professor of Biomedical Engineering and Orthopaedics at Case Western Reserve University and Director, Cleveland Functional Electrical Stimulation Center. The major area of Dr. Peckham's research is in rehabilitation engineering and neuroprostheses. He’s also the Founder for the Institute for Functional Restoration at the Case Western School of Medicine and the Co-Director of MetroHealth Rehabilitation Institute of Ohio. A holder of eight patents, he is a member of multiple councils, Dr. Peckham is also a fellow of the American Institute of Medical and Biological Engineering.

Affiliations and Expertise

Case Western Reserve University, Cleveland, OH, USA

Ali Rezai

Dr. Rezai is currently executive chair and vice president of neurosciences for WVU Medicine. He also serves as associate dean and the John D. Rockefeller IV tenured professor in neurosciences at the WVU School of Medicine. Dr. Rezai has published over 150 peer reviewed articles, more than 30 book chapters, and serves on the editorial board of five journals. Dr. Rezai is currently the Past President of the Congress of Neurological Surgeons (CNS), the largest neurosurgical societies in the world, as well as the Past President North American Neuromodulation Society (NANS), and the American Society of Stereotactic and Functional Neurosurgery (ASSFN).Dr. Rezai’s research focuses on mechanisms of neurostimulation, and developing neuromodulation devices and novel therapeutic strategies for treatment of neurological disorders.

Affiliations and Expertise

West Virginia University, Morgantown, WV USA

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