Neurological Rehabilitation is the latest volume in the definitive Handbook of Clinical Neurology series. It is the first time that this increasing important subject has been included in the series and this reflects the growing interest and quality of scientific data on topics around neural recovery and the practical applications of new research. The volume will appeal to clinicians from both neurological and rehabilitation backgrounds and contains topics of interest to all members of the multidisciplinary clinical team as well as the neuroscience community. The volume is divided into five key sections. The first is a summary of current research on neural repair, recovery and plasticity. The authors have kept the topics readable for a non-scientific audience and focused on the aspects of basic neuroscience that should be most relevant to clinical practice. The next section covers the basic principles of neurorehabilitation, including excellent chapters on learning and skill acquisition, outcome measurement and functional neuroimaging. The key clinical section comes next and includes updates and reviews on the management of the main neurological disabling physical problems, such as spasticity, pain, sexual functioning and dysphagia. Cognitive, emotional and behavioural problems are just as important and are covered in the next section, with excellent chapters, for example, on memory and management of executive dysfunction. The final part draws the sections on symptom management together by discussing the individual diseases that are most commonly seen in neurorehabilitation and providing an overview of the management of the disability associated with those disorders. The volume is a definitive review of current neurorehabilitation practice and will be valuable to a wide range of clinicians and scientists working in this rapidly developing field.

Key Features

*A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology.
*International list of contributors including the leading workers in the field.
*Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care.


Clinical neurologists and research neuroscientists

Table of Contents

Series Page

Handbook of Clinical Neurology 3rd Series




Chapter 1. Neural plasticity and its contribution to functional recovery


Sites of plasticity

Window of opportunity

Functional relevance

Plasticity, metaplasticity, and homeostatic plasticity

Genetic Influences

Noninvasive techniques capable of evaluating neuroplasticity in humans

Modulation of neuroplasticity



Chapter 2. Plasticity of cerebral functions


Natural history of recovery after stroke

Mechanisms underlying recovery after cortical injury

Plasticity in the somatotopy of cortical motor maps as a reflection of vicarious function

Premotor cortex as a potential locus for vicarious function

Structural changes in motor cortex after stroke



Chapter 3. Neuroplasticity in the spinal cord


Spinal cord injury

Mechanisms of plasticity in recovery from spinal cord injury


Chapter 4. Neural tissue transplantation, repair, and rehabilitation


Cell replacement and structural repair by neural transplantation

Mechanisms of functional recovery after neural transplantation

Transplant-derived plasticity

Behavioral experience affects transplant integration and function

Learning (and relearning) to use the transplant

Rehabilitation strategies to promote transplant function


Chapter 5. Clinical trials in neurorehabilitation


Complexity of human randomized clinical trials

Beyond randomized controlled trials

Translation of evidence from clinical trials in neurorehabilitation to clinical practice





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© 2013
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About the editors

Michael Barnes

Affiliations and Expertise

Professor of Neurological Rehabilitation, University of Newcastle upon Tyne, Newcastle upon Tyne, UK

David Good

Affiliations and Expertise

Professor and Chair, Department of Neurology, PennState Milton S. Hershey Medical Center, Hershey, PA, USA