Neurologic Aspects of Systemic Disease, Part II

Neurologic Aspects of Systemic Disease, Part II

1st Edition - January 9, 2014

Write a review

  • Editors: José Biller, José Ferro
  • Hardcover ISBN: 9780702040870
  • eBook ISBN: 9780702044335

Purchase options

Purchase options
Available
DRM-free (PDF, Mobi, EPub)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order

Description

Systemic disease involves several parts of the body or the complete system. Neurologic Aspects of Systemic Disease, a two-part volume in the Handbook of Clinical Neurology series, focuses on the specific neurologic aspects of systemic disease. Part 2 includes coverage of gastrointestinal and hepatobiliary, endocrinologic, and metabolic diseases, as well as nutritional, environmental, and hematologic disorders. Each chapter provides a complete introduction to the neurologic aspect and provides the best known diagnostic and treatment practices. The collection is a valuable and trusted resource for clinical neurologists, research neurologists, neuroscientists, and general medical professionals: a first stop for a focused review of the state of the art for understanding the neurologic impact of each covered disease.

Key Features

  • A comprehensive introduction and overview of the neurologic aspects of systemic disease
  • Part 2 covers of gastrointestinal/hepatobiliary, endocrinologic, and metabolic diseases and nutritional, environmental, and hematologic disorders
  • Each chapter focuses on the neurologic aspects related to a specific disease presentation

Table of Contents

  • Handbook of Clinical Neurology 3rd Series
    Foreword
    Preface
    Contributors
    SECTION 5: Neurologic aspects of gastrointestinal/hepatobiliary diseases
    Chapter 39: The neurologic complications of bariatric surgery
    Abstract

    Obesity: an overview

    Bariatric surgery

    Conclusions

    Chapter 40: Neurologic manifestations of inflammatory bowel diseases
    Abstract

    Introduction

    Neurologic manifestations in inflammatory bowel disease

    Peripheral nervous system

    Cranial neuropathies

    Cerebrovascular complications

    Cerebral venous thrombosis

    Demyelinating disease

    Other central nervous system complications

    Psychiatric syndromes

    Medication-induced neurolgic complications

    Chapter 41: Gluten-related neurologic dysfunction
    Abstract

    Historical perspective

    Epidemiology of neurologic manifestations

    The diagnosis of gluten-related diseases

    The spectrum of gluten-related neurologic manifestations

    Pathogenesis

    Conclusions

    Chapter 42: Neurologic manifestations of malabsorption syndromes
    Abstract

    Introduction

    Absorption and malabsorption

    Neurologic dysfunction in malabsorption syndromes

    Conclusion

    Chapter 43: Commonly used gastrointestinal drugs
    Abstract

    Introduction

    Antiemetics

    Drugs affecting gastrointestinal motility

    Laxatives

    Drugs for acid-related disorders

    Central hyperthermia syndromes and gastrointestinal drugs

    Conclusion

    Acknowledgement

    Chapter 44: Neurologic manifestations of acute liver failure
    Abstract

    Introduction

    Historical perspective

    Clinical presentation

    Laboratory tests and Imaging studies

    Referral to transplant center

    Medical management of acute liver failure

    Management of cerebral edema

    Outcome

    Artificial livers

    Chapter 45: Portosystemic encephalopathy
    Abstract

    History

    Clinical findings

    Differential diagnosis

    Diagnosis of minimal hepatic encephalopathy

    Natural history

    Laboratory investigations

    Neuroimaging investigations

    Pathology/pathophysiology

    Management

    Conclusions

    Chapter 46: Neurotoxicity of commonly used hepatic drugs
    Abstract

    Introduction

    Calcineurin inhibitors

    Other medications used for immunosuppresion after orthotopic liver transplantation

    Interferons, Ribavirin and Nucleoside and Nucleotide Analogs Used in the Treatment of Hepatitis B and C Virus

    Conclusions

    SECTION 6: Neurologic aspects of endocrinologic diseases
    Chapter 47: Neurology of the pituitary
    Abstract

    Background

    Pituitary adenomas: epidemiology and pathogenesis

    Neurologic manifestations of pituitary lesions

    Hypopituitarism

    Secondary adrenal insufficiency

    Secondary hypothyroidism

    Secondary hypogonadism

    Growth hormone deficiency

    Prolactin deficiency

    Central diabetes insipidus

    Evaluation of the hypothalamic–pituitary axis

    Hormonal hyperfunction

    Imaging

    Management of pituitary tumors

    Future directions

    Chapter 48: Thyroid disease and the nervous system
    Abstract

    Introduction

    Neurologic complications of hypothyroidism

    Miscellaneous neurologic conditions and hypothyroidism

    Neurologic complications of hyperthyroidism and graves' disease

    Miscellaneous neurologic disorders and thyroid disease

    Chapter 49: Neurologic disorders of mineral metabolism and parathyroid disease
    Abstract

    Calcium, phosphorus, and magnesium homeostasis

    Disorders associated with hypercalcemia

    Disorders Associated with Hypocalcemia

    Conclusion

    Chapter 50: Neurologic complications of disorders of the adrenal glands
    Abstract

    Introduction

    Historical aspects

    Function of the adrenal glands

    Cushing syndrome

    Adrenal insufficiency

    Adrenoleukodystrophy and adrenomyeloneuropathy

    Hyperaldosteronism

    Disorders of the adrenal medulla

    Acknowledgements

    Chapter 51: Diabetic neuropathy
    Abstract

    History and epidemiology

    Classification and clinical findings

    Laboratory investigations

    Risk factors

    Pathophysiology

    Treatment of diabetic neuropathies

    Conclusions

    Chapter 52: Neurologic disorders associated with disease of the ovaries and testis
    Abstract

    Introduction

    History

    Clinical findings

    Natural history

    Laboratory investigations

    Neuroimaging investigations

    Pathology

    Management

    Infertility, infecundity, androgen receptor insensitivity syndrome, and primary ovarian failure in patients with neurologic disorders

    Chapter 53: Neurologic complications of multiple endocrine syndromes
    Abstract

    Introduction

    Autoimmune polyglandular syndrome type I

    Autoimmune polyglandular syndrome type II

    Autoimmune polyglandular syndrome type III

    Multiple endocrine neoplasia

    Chapter 54: Commonly used endocrine drugs
    Abstract

    Introduction

    Hypothalamic and pituitary hormones and analogs

    Thyroid and parathyroid agents

    Drugs used in diabetes

    SECTION 7: Neurologic aspects of metabolic diseases
    Chapter 55: Disorders of purines and pyrimidines
    Abstract

    Overview

    Disorders of purine metabolism

    Disorders of pyrimidine metabolism

    Summary

    Chapter 56: Porphyria and its neurologic manifestations
    Abstract

    Introduction

    Background

    Clinical presentation

    Risk factors for attacks

    Mechanisms of nervous system dysfunction

    Diagnosis

    Treatment

    Conclusions

    Chapter 57: Disorders of heavy metals
    Abstract

    Introduction

    Copper disorders

    Iron disorders

    Chapter 58: Disorders of bone and bone mineral metabolism
    Abstract

    Calcium and parathyroid hormone disorders

    Hypercalcemia

    Primary hyperparathyroidism

    Hypocalcemia

    Hypoparathyroidism and pseudohypoparathyroidism

    Magnesium and phosphorus disorders

    Osteoporosis

    Paget’s Disease

    Hypophosphatasia

    Vitamin D and central nervous system from fetal life to aging, and from good health to illness

    SECTION 8: Neurologic aspects of nutritional disorders
    Chapter 59: Hydrosoluble vitamins
    Abstract

    History

    Thiamin (vitamin B1)

    Riboflavin (vitamin B2)

    Niacin or nicotinic acid (vitamin B3)

    Pantothenic acid (vitamin B5)

    Pyridoxine or pyridoxal (vitamin B6)

    Ascorbic acid (vitamin C)

    Conclusions (including future directions)

    Chapter 60: Neurologic aspects of cobalamin (B12) deficiency
    Abstract

    Introduction

    Cobalamin

    Requirement for and sources of cobalamin

    Functions and kinetics

    Causes of cobalamin deficiency

    Clinical manifestations of cobalamin deficiency

    Investigations

    Pathology

    Management

    Chapter 61: The neurology of folic acid deficiency
    Abstract

    Historical background

    Folate metabolism

    The neurology of folate-deficient megaloblastic anemia

    Neuropsychiatric disorders without anemia or macrocytosis

    Folate, homocysteine, depression, dementia, and aging

    Folic acid and epilepsy

    Treatment issues

    Neural tube defects and their prevention

    Disorders of folate metabolism in infancy and childhood

    Clinical dissociation

    Metabolic mechanisms

    Conclusions

    Summary

    SECTION 9: Neurologic aspects of environmental disorders
    Chapter 62: Disorders of body temperature
    Abstract

    Introduction

    Mechanisms of heat exchange

    Basic pathogenesis of hyperthermia

    Basic pathogenesis of hypothermia

    Heat-related illness

    Drug-induced hyperthermia

    Fever in neurologic practice

    Accidental hypothermia

    Therapeutic body temperature manipulation: current technology

    Conclusions

    Chapter 63: Neurology and diving
    Abstract

    Decompression sickness

    Arterial gas embolism

    Epidemiology

    Clinical manifestations and diagnosis

    Prevention

    Diagnosis

    Treatment

    Long-term neurologic consequences

    Appendix: case examples

    Chapter 64: Neurologic complications of carbon monoxide intoxication
    Abstract

    Introduction

    Pathophysiology

    Pathology

    Clinical findings

    Diagnosis

    Laboratory tests

    Neuroimaging studies

    Differential diagnosis

    Treatment

    Prognosis

    Chapter 65: Lightning and thermal injuries
    Abstract

    History (including terminology)

    Clinical findings

    Natural history

    Laboratory investigations

    Neuroimaging investigations

    Pathology

    Management

    Conclusions (including future directions)

    Chapter 66: Venomous snake bites, scorpions, and spiders
    Abstract

    Introduction

    Pathophysiology of envenoming

    Snake envenoming

    Scorpions

    Spiders

    Ant, Bee, Hornet, and Wasp (insecta, hymenoptera) stings

    Tick paralysis

    Other natural toxins

    Management of snake bite

    Conclusion

    Acknowledgments

    SECTION 10: Neurologic aspects of hematologic disorders
    Chapter 67: Anemias excluding cobalamin and folate deficiencies
    Abstract

    Introduction

    Iron deficiency anemia

    Anemia of chronic inflammation/disease

    Megaloblastic anemias excluding folate and cobalamin deficiencies

    Bone marrow failure syndromes

    Hemolytic anemias

    Conclusions

    Chapter 68: Neurologic complications of sickle cell disease
    Abstract

    History

    Clinical findings

    Natural history

    Laboratory investigations

    Neuroimaging

    Genetics

    Pathology

    Management

    Conclusions

    Chapter 69: Neurologic aspects of lymphoma and leukemias
    Abstract

    Introduction

    Lymphomas

    Leukemias

    Conclusion

    Chapter 70: Bleeding diathesis and hemophilias
    Abstract

    Introduction

    Hemophilia

    Acquired hemophilia

    Neurologic manifestations in patients with hemophilia

    Rare bleeding disorders

    Deficiencies of fibrinolytic pathway: α2-antiplasmin and plasminogen activator inhibitor-1 (pai-1) deficiency

    Von Willebrand disease

    Platelet function disorders

    Role of hemophilia treatment centers in the management of bleeding disorders

    Summary

    Chapter 71: Thrombophilic states
    Abstract

    Thrombophilic states

    Thrombophilic states and cerebral venous sinus thrombosis

    Thrombophilic states and ischemic stroke

    Conclusions

    Chapter 72: Chronic myeloproliferative diseases
    Abstract

    Introduction and definitions

    Polycythemia vera

    Essential thrombocythemia

    Primary myelofibrosis

    Chapter 73: Neurologic aspects of plasma cell disorders
    Abstract

    Introduction

    Monoclonal gammopathy of undetermined significance

    Smoldering multiple myeloma

    Multiple myeloma

    Nonsecretory myeloma

    Solitary plasmacytoma

    POEMS syndrome

    Waldenström macroglobulinemia

    Al amyloidosis (immunoglobulin light chain amyloidosis)

    Cryoglobulinemia

    Conclusion

    Chapter 74: Neurologic manifestations of Henoch–Schönlein purpura
    Abstract

    General aspects

    Epidemiology of nervous system manifestations

    Nervous system manifestations

    Investigations

    Differential diagnosis

    Management

    Prognosis

    Chapter 75: Hemolytic uremic syndrome
    Abstract

    Introduction

    Definition

    Epidemiology and etiology

    Pathophysiology

    Clinical manifestations

    Neurologic findings and sequelae

    Diagnosis

    Treatment

    Chapter 76: Commonly used drugs in hematologic disorders
    Abstract

    Agents used to treat benign hematologic disorders

    Management of hemorrhagic complications of anticoagulation

    Agents used to treat hematologic malignancies

    Index

Product details

  • No. of pages: 736
  • Language: English
  • Copyright: © Elsevier 2014
  • Published: January 9, 2014
  • Imprint: Elsevier
  • Hardcover ISBN: 9780702040870
  • eBook ISBN: 9780702044335

About the Editors

José Biller

José Biller, M.D., FACP, FAAN, FANA, FAHA

Loyola University Chicago, Maywood, IL, USA

Dr. José Biller is Professor of Neurology and Neurological Surgery and Chairperson of the Department of Neurology at Loyola University Chicago Stritch School of Medicine. Dr. Biller served as Director of the American Board of Psychiatry and Neurology (ABPN) from 1994 to 2001, and President of the ABPN in 2001. He is Chief Editor of the Journal of Stroke and Cerebrovascular Diseases , and an editorial board member and reviewer for an array of other national and international journals and publications. He is a Fellow of the American Academy of Neurology, American Neurological Association, American College of Physicians, and the Stroke Council of the American Heart Association. He has published more than 370 peer-reviewed articles, more than 150 book chapters, and numerous books.

Affiliations and Expertise

Neurology, Professor and Chairman, Department of Neurology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA

José Ferro

Affiliations and Expertise

Professor and Chairman, Serviço de Neurologia, Hospital de Santa Maria, University of Lisboa, Portugal

Ratings and Reviews

Write a review

There are currently no reviews for "Neurologic Aspects of Systemic Disease, Part II"