Neuroimaging in Parkinson’s Disease and Related Disorders

Neuroimaging in Parkinson’s Disease and Related Disorders

1st Edition - November 1, 2022

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  • Editors: Edoardo de Natale, Marios Politis, Heather Wilson
  • Hardcover ISBN: 9780128216514

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Description

Neuroimaging in Parkinson’s Disease and Related Disorders discusses the advances of molecular, structural and functional neuroimaging techniques associated with the etiology, pathophysiology, effects and complications of novel therapies in Parkinson’s and related disorders. With new neuroimaging methodologies emerging over the past five years, this book provides a comprehensive overview of new technologies and research. Sections discuss the biomarker value of neuroimaging of the brain to understand disease progression in vivo in actual patients with Parkinson’s disease and related disorders. Readers will be updated on in vivo pathology and pathophysiology in Parkinson’s disease and in a number of related disorders. Also discussed is the association between clinical symptoms, clinical progression, and molecular, structural and functional changes in the brain of patients with Parkinson’s disease and related disorders.

Key Features

  • Comprehensive overview of biomarker value of neuroimaging of the brain to understand disease progression in vivo in actual patients with Parkinson’s disease and related disorders
  • Helps readers understand the in vivo pathology and pathophysiology in Parkinson’s disease and in a number of related disorders
  • Discusses the association between clinical symptoms, clinical progression, and molecular, structural and functional changes in the brain of patients with Parkinson’s and related disorders

Readership

Neurologists, neuroscientists, nuclear medicine professionals, Pharma researchers

Table of Contents

  • Section I. Introduction
    1. Parkinson’s disease and related disorders: The pursuit for reliable readouts and the role of neuroimaging
    2. Advances Magnetic Resonance Imaging
    3. Advances in Molecular Imaging Methodology

    Section II. Clinical Applications in Parkinson Disease
    4. Dopaminergic molecular imaging in familial and idiopathic PD
    5. Serotonergic molecular imaging in familial and idiopathic PD
    6. Other systems PET and SPECT imaging in familial and idiopathic PD
    7. Structural MRI in familial and idiopathic PD
    8. Functional MRI in familial and idiopathic PD
    9. Molecular imaging in Prodromal PD

    Section III. Clinical Applications in Lewy Body Dementias
    10. Molecular Imaging evidence in favour or against PDD & DLB overlap
    11. MR Imaging in PD-MCI, PDD & DLB

    Section IV. Clinical Applications in Atypical Parkinsonian Disorders
    12. Neuroimaging in MSA
    13. Neuroimaging in PSP
    14. Neuroimaging in CBS

    Section V. Clinical Applications in Other Movement Disorders
    15. Molecular imaging in Huntington's Disease
    16. Magnetic Resonance Imaging in Huntington’s disease
    17. Neuroimaging in Essential Tremor
    18. Neuroimaging in Restless leg syndrome
    19. Neuroimaging in Dystonia
    20. Demyelination Syndromes and Movement Disorders

    Section VI. Conclusions
    21. The Future of Neuroimaging and the Application for Robust Measures in Clinical Trials

Product details

  • No. of pages: 500
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: November 1, 2022
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128216514

About the Editors

Edoardo de Natale

Edoardo Rosario de Natale is a Senior Clinical Research Fellow at the Neurodegeneration Imaging Group at University of Exeter, lead of the clinical applications at the Mireille Gillings Neuroimaging Centre and honorary Consultant at the Royal Devon & Exeter NHS Foundation Trust.

Affiliations and Expertise

Neurodegeneration Imaging Group, University of Exeter Medical School, London, UK

Marios Politis

Professor Marios Politis is a professor of neurology and neuroimaging, consultant neurologist, the director of the Neurodegeneration Imaging Group, and the head of Neurology Unit at King’s College London. His research involves clinical observation, and the use of PET and MR imaging as a method of investigating etiology, pathophysiology, and effects and complications of novel therapies in neurodegenerative disorders such as Parkinson’s disease. He has served as chief investigator in a number of observational and interventional trials. Professor Politis has received a high number of awards and distinctions such as from the Movement Disorder Society, Royal College of Physicians, Society of Nuclear Medicine and Molecular Imaging, and European Academy of Neurology. He is a recipient of the Jon Stolk Award in Movement Disorders from the American Academy of Neurology.

Affiliations and Expertise

Professor of Neurology and Neuroimaging, Consultant Neurologist, Director of the Neurodegeneration Imaging Group, and the Head of Neurology Unit, King’s College London, UK

Heather Wilson

Heather Wilson, MSc. PhD, is a Senior Research Fellow at the Neurodegeneration Imaging Group, and Imaging Methodology Lead at the Mireille Gillings Neuroimaging Centre, University of Exeter.

Affiliations and Expertise

Neurodegeneration Imaging Group, University of Exeter Medical School, London, UK

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