Description

Morphological and functional studies revealed a complex system of primary sensory neurons that parallels the autonomic nervous system not only in its extent, but probably also in its significance. Neuropeptides released from activated nociceptive afferent nerves play a pivotal role in inflammatory reactions and pain, significantly modulate cardiac, vascular, respiratory, gastrointestinal and immune functions and influence the protective, restorative and trophic functions of somatic and visceral tissues. Several chapters of the book deal with the therapeutic potential of a new class of putative pain relieving agents acting through TRPV1, the capsaicin/vanilloid receptor, a specific ion channel that transmits pain.

Key Features

*Neurogenic inflammation in historical perspective *Cardiac protection by nociceptive afferents *Molecular mechanisms of nociception *Sensory mechanisms in migraine pathophysiology *Vagal signaling of visceral inflammation *Neurogenic mechanisms in arthritis *Therapeutic implications of vanilloid-type compounds

Readership

Neuroscientists, Immunologists, Pathologists, Pharmacologists, Internists, Vetrinarians, Physiologists, Biologists

Details

No. of pages:
368
Language:
English
Copyright:
© 2009
Published:
Imprint:
Elsevier Science
eBook ISBN:
9780080932620
Print ISBN:
9780444532299
Print ISBN:
9780444558770

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