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Neurodevelopmental Disorders - 1st Edition - ISBN: 9780128144091, 9780128144107

Neurodevelopmental Disorders

1st Edition

Comprehensive Developmental Neuroscience

Editors in Chief: John Rubenstein Pasko Rakic
Editors: Bin Chen Kenneth Kwan
Hardcover ISBN: 9780128144091
eBook ISBN: 9780128144107
Imprint: Academic Press
Published Date: 24th May 2020
Page Count: 426
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Neurodevelopmental Disorders, the latest release in the Comprehensive Developmental Neuroscience series, presents the most thorough coverage available, addressing all aspects on how the nervous system and its components develop. This book brings together the latest research in this rapidly evolving field, with section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on neurodevelopmental disorders in humans and experimental organisms. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms.

Key Features

  • Features leading experts in various subfields as section editors and article authors
  • Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship
  • Covers disorders of the nervous system that arise through defects in neural development


Neuroscience, developmental biology researchers, including stem cells, aging and diseases. Translational neuroscience researchers

Table of Contents


1. Neurocutaneous Syndromes: Neurofibromatosis and Tuberous Sclerosis

Mustafa Sahin

2. Azetidine-2-Carboxylic Acid and Other Nonprotein Amino Acids in the Pathogenesis of Neurodevelopmental Disorders

Edward Rubenstein

3. Autisms

Antonio M. Persico

4. Developmental basis of ZIKA virus induced neuropathology

Hongjun Song and Guo-li Ming

5. iPSC Models of Human Neurodevelopmental Disorders

Flora M. Vaccarino

6. Cornelia de Lange Syndrome: Insights into Neural Development from Clinical Studies and Animal Models

Anne Leighton Calof, Rosaysela Santos, Laura Groves, Chris Oliver and Arthur D. Lander

7. Fetal Alcohol Spectrum Disorder

Sandra Mooney

8. Neural Tube Defects

Lee Niswander

9. Developmental disabilities, autism and schizophrenia at a single locus: complex gene regulation and genomic instability of 15q11-q13 cause a range of neurodevelopmental disorders

Lawrence T. Reiter

10. Lissencephalies

Elliott Sherr and Bethany Johnson-Kerner

11. Rett Syndrome

Jeffrey Lorenz Neul

12. Focal Cortical Dysplasias

Christopher A. Walsh and Alissa M. D’Gama

13. White Matter Disorders

Benjamin Lawrence Lynner Clayton, Paul Tesar, Kevin Cameron Allan, Zachary Scott Nevin and Matthew Sean Elitt

14. Language Impairments

R. Holly Fitch

15. Fragile X Syndrome

Randi Hagerman

16. Microcephalies

Youngshin Lim and Jeffrey Alan Golden


No. of pages:
© Academic Press 2020
24th May 2020
Academic Press
Hardcover ISBN:
eBook ISBN:

About the Editors in Chief

John Rubenstein

Dr. Rubenstein is a Professor in the Department of Psychiatry at the University of California, San Francisco. He also serves as a Nina Ireland Distinguished Professor in Child Psychiatry at the Nina Ireland Laboratory of Developmental Neurobiology. His research focuses on the regulatory genes that orchestrate development of the forebrain. Dr. Rubenstein's lab has demonstrated the role of specific genes in regulating neuronal specification, differentiation, migration and axon growth during embryonic development and on through adult life. His work may help to explain some of the mechanisms underlying human neurodevelopmental disorders such as autism.

Affiliations and Expertise

Professor, Department of Psychiatry, University of California, San Francisco, USA

Pasko Rakic

Dr. Rakic is currently at the Yale School of Medicine, Department of Neuroscience, where his main research interest is in the development and evolution of the human brain. After obtaining his MD from the University of Belgrade School of Medicine, his research career began in 1962 with a Fulbright Fellowship at Harvard University after which he obtained his graduate degrees in Developmental Biology and Genetics. He held a faculty position at Harvard Medical School for 8 years prior to moving to Yale University, where he founded and served as Chair of the Department of Neurobiology for 37 years, and also founder and director of the Kavli Institute for Neuroscience. In 2015, he returned to work full-time on his research projects, funded by US Public Health Services and various private foundations. He is well known for his studies of the development and evolution of the brain, in particular his discovery of basic cellular and molecular mechanisms of proliferation and migration of neurons in the cerebral cortex. He was president of the Society for Neuroscience and popularized this field with numerous lectures given in over 35 counties. In 2008, Rakic shared the inaugural Kavli Prize in Neuroscience with Thomas Jessell and Stan Grillner. He is currently the Dorys McConell Duberg Professor of Neuroscience and serves on Advisory Boards and Scientific Councils of a number of Institutions and Research Foundations.

Affiliations and Expertise

Department of Neuroscience, Yale School of Medicine, USA

About the Editors

Bin Chen

Dr. Chen is Professor of Molecular, Cell, and Developmental Biology at the University of California, Santa Cruz. Research in her laboratory focuses on the cellular and molecular mechanisms that underlie the generation of diverse cell types in the brain, and the assembly of these cell types into functional neural circuits. Dr. Chen completed her graduate study with Dr. Sidney Strickland at Stony Brook University-SUNY, and her post-doctoral training in the laboratory of Dr. Susan McConnell at Stanford University. She has 22 years of experience in genetics and developmental neurobiology research. Her laboratory has been funded by the March of Dimes Foundation, California Institute of Regenerative Medicine, and National Institute of Health.

Affiliations and Expertise

Professor of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, USA

Kenneth Kwan

Dr. Kwan is Assistant Professor of Human Genetics and Research Assistant Professor in the Molecular and Behavioral Neuroscience Institute at the University of Michigan Medical School. Research in his laboratory is aimed at the molecular and cellular mechanisms that underlie normal neural circuit assembly in the cerebral cortex and their dysregulation in human neurodevelopmental disorders, in particular autism spectrum disorder, fragile X syndrome, and schizophrenia. Dr. Kwan completed his graduate and post-doctoral training in the laboratory of Dr. Nenad Sestan at Yale School of Medicine. He has 14 years of experience in developmental neurobiology research and his worked has been recognized by awards from the Brain Research Foundation, March of Dimes Foundation, Simons Foundation, and Cajal Club.

Affiliations and Expertise

Assistant Professor of Human Genetics and Research Assistant Professor, Molecular and Behavioral Neuroscience Institute, University of Michigan, USA


"This relatively succinct volume successfully meets the challenge of summarizing a field as broad as developmental neuroscience. While it could not comprehensively address every disorder, the examples are well chosen and highlight advances from diverse disciplines that are leading to major improvement in our understanding of these complex and often rare conditions. There is a problematic chapter on the "autisms," but the authors do an admirable job. They describe specific syndromes, rare genetic variants, and environmental etiologies. This can help to explain endophenotypes and may point to more broad applications for understanding developmental pathways leading to new treatments." --Doody Reviews

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