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Neurodevelopmental Disorders, the latest release in the Comprehensive Developmental Neuroscience series, presents the most thorough coverage available, addressing all aspects on how the nervous system and its components develop. This book brings together the latest research in this rapidly evolving field, with section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on neurodevelopmental disorders in humans and experimental organisms. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms.
- Features leading experts in various subfields as section editors and article authors
- Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship
- Covers disorders of the nervous system that arise through defects in neural development
Neuroscience, developmental biology researchers, including stem cells, aging and diseases. Translational neuroscience researchers
I: NEURAL DEVELOPMENTAL DISORDERS
1. Neurocutaneous Syndromes: Neurofibromatosis and Tuberous Sclerosis
2. Azetidine-2-Carboxylic Acid and Other Nonprotein Amino Acids in the Pathogenesis of Neurodevelopmental Disorders
Antonio M. Persico
4. Developmental basis of ZIKA virus induced neuropathology
Hongjun Song and Guo-li Ming
5. iPSC Models of Human Neurodevelopmental Disorders
Flora M. Vaccarino
6. Cornelia de Lange Syndrome: Insights into Neural Development from Clinical Studies and Animal Models
Anne Leighton Calof, Rosaysela Santos, Laura Groves, Chris Oliver and Arthur D. Lander
7. Fetal Alcohol Spectrum Disorder
8. Neural Tube Defects
9. Developmental disabilities, autism and schizophrenia at a single locus: complex gene regulation and genomic instability of 15q11-q13 cause a range of neurodevelopmental disorders
Lawrence T. Reiter
Elliott Sherr and Bethany Johnson-Kerner
11. Rett Syndrome
Jeffrey Lorenz Neul
12. Focal Cortical Dysplasias
Christopher A. Walsh and Alissa M. D’Gama
13. White Matter Disorders
Benjamin Lawrence Lynner Clayton, Paul Tesar, Kevin Cameron Allan, Zachary Scott Nevin and Matthew Sean Elitt
14. Language Impairments
R. Holly Fitch
15. Fragile X Syndrome
Youngshin Lim and Jeffrey Alan Golden
- No. of pages:
- © Academic Press 2020
- 24th May 2020
- Academic Press
- Hardcover ISBN:
- eBook ISBN:
Dr. Rubenstein is a Professor in the Department of Psychiatry at the University of California, San Francisco. He also serves as a Nina Ireland Distinguished Professor in Child Psychiatry at the Nina Ireland Laboratory of Developmental Neurobiology. His research focuses on the regulatory genes that orchestrate development of the forebrain. Dr. Rubenstein's lab has demonstrated the role of specific genes in regulating neuronal specification, differentiation, migration and axon growth during embryonic development and on through adult life. His work may help to explain some of the mechanisms underlying human neurodevelopmental disorders such as autism.
Professor, Department of Psychiatry, University of California, San Francisco, USA
Dr. Rakic is currently at the Yale School of Medicine, Department of Neuroscience, where his main research interest is in the development and evolution of the human brain. After obtaining his MD from the University of Belgrade School of Medicine, his research career began in 1962 with a Fulbright Fellowship at Harvard University after which he obtained his graduate degrees in Developmental Biology and Genetics. He held a faculty position at Harvard Medical School for 8 years prior to moving to Yale University, where he founded and served as Chair of the Department of Neurobiology for 37 years, and also founder and director of the Kavli Institute for Neuroscience. In 2015, he returned to work full-time on his research projects, funded by US Public Health Services and various private foundations. He is well known for his studies of the development and evolution of the brain, in particular his discovery of basic cellular and molecular mechanisms of proliferation and migration of neurons in the cerebral cortex. He was president of the Society for Neuroscience and popularized this field with numerous lectures given in over 35 counties. In 2008, Rakic shared the inaugural Kavli Prize in Neuroscience with Thomas Jessell and Stan Grillner. He is currently the Dorys McConell Duberg Professor of Neuroscience and serves on Advisory Boards and Scientific Councils of a number of Institutions and Research Foundations.
Department of Neuroscience, Yale School of Medicine, USA
Dr. Chen is Professor of Molecular, Cell, and Developmental Biology at the University of California, Santa Cruz. Research in her laboratory focuses on the cellular and molecular mechanisms that underlie the generation of diverse cell types in the brain, and the assembly of these cell types into functional neural circuits. Dr. Chen completed her graduate study with Dr. Sidney Strickland at Stony Brook University-SUNY, and her post-doctoral training in the laboratory of Dr. Susan McConnell at Stanford University. She has 22 years of experience in genetics and developmental neurobiology research. Her laboratory has been funded by the March of Dimes Foundation, California Institute of Regenerative Medicine, and National Institute of Health.
Professor of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, USA
Dr. Kwan is Assistant Professor of Human Genetics and Research Assistant Professor in the Molecular and Behavioral Neuroscience Institute at the University of Michigan Medical School. Research in his laboratory is aimed at the molecular and cellular mechanisms that underlie normal neural circuit assembly in the cerebral cortex and their dysregulation in human neurodevelopmental disorders, in particular autism spectrum disorder, fragile X syndrome, and schizophrenia. Dr. Kwan completed his graduate and post-doctoral training in the laboratory of Dr. Nenad Sestan at Yale School of Medicine. He has 14 years of experience in developmental neurobiology research and his worked has been recognized by awards from the Brain Research Foundation, March of Dimes Foundation, Simons Foundation, and Cajal Club.
Assistant Professor of Human Genetics and Research Assistant Professor, Molecular and Behavioral Neuroscience Institute, University of Michigan, USA
"This relatively succinct volume successfully meets the challenge of summarizing a field as broad as developmental neuroscience. While it could not comprehensively address every disorder, the examples are well chosen and highlight advances from diverse disciplines that are leading to major improvement in our understanding of these complex and often rare conditions. There is a problematic chapter on the "autisms," but the authors do an admirable job. They describe specific syndromes, rare genetic variants, and environmental etiologies. This can help to explain endophenotypes and may point to more broad applications for understanding developmental pathways leading to new treatments." --Doody Reviews
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