Neurocircuitry of Addiction

Neurocircuitry of Addiction

1st Edition - December 1, 2022

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  • Editor: Nicholas Gilpin
  • Paperback ISBN: 9780128234532

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Neurocircuitry of Addiction focuses on common neural circuits that underly the effects of addictive substances, providing a more holistic view of how these agents produce their effects. This book is organized by brain circuits and their role in addiction, including ventral tegmental area (VTA) circuits, striatal circuits, prefrontal cortical (PFC) circuits, extended amygdala circuits, neuroendocrine circuits, and circadian circuits. It includes a foreword by renowned experts Dr. George Koob (Director of the National Institute of Alcohol Abuse and Alcoholism ) and Dr. Nora Volkow (the Director of the National Institute of Drug Abuse).According to the Substance Abuse and Mental Health Services of America, approximately, 21 million Americans are addicted to at least one substance, and about 20% of Americans who have been diagnosed with depression or anxiety disorder also have substance use disorder.

Key Features

  • Covers multiple areas of brain systems, including habenula, insula and cerebellum
  • Reviews the innovative tools needed to investigate neural circuits
  • Identifies how drugs affect neurons and neural circuits
  • Includes both human and animal models


Undergraduate psychology; neuroscience students; graduate students in neuroscience; psychology, psychiatry, scientists in the addiction field. Addiction psychiatrists; medical students; physicians who treat substance use disorder

Table of Contents

  • 1. Foreword
    George Koob, NIAAA Director and/or Nora Volkow, NIDA Director
    2. Leveraging circuits to understand addiction
    Nicholas W. Gilpin, Professor, LSUHSC
    3. Ventral tegmental area (VTA) circuits
    Elyssa Margolis, Associate Professor, UCSF, Marisela Morales, Section Chief NIDA
    4. Striatal circuits
    Patricia Janak, Professor, Johns Hopkins, Veronica Alvarez, Sr. Investigator, NIAAA, David Lovinger, Section Chief, NIAAA
    5. Prefrontal cortical (PFC) circuits
    John Mantsch, Professor and Chair, Marquette, Judson Chandler, Professor, MUSC
    6. Extended amygdala circuits
    Olivier George, Associate Professor, UCSD, Jeffrey Weiner, Professor, Wake Forest, Melissa Herman, Assistant Professor, UNC
    7. Doral raphe nucleus (5-HT) circuits
    Thomas Kash, Associate Professor, UNC
    8. Locus coeruleus (NE) circuits
    Gary Aston-Jones, Professor and Center Director, Rutgers, Danny Winder, Professor & Center Director, Vanderbilt, Zoe McElligott, Assistant Professor, UNC
    9. Neuroendocrine (HPA) circuits
    Rajita Sinha, Professor, Yale, Heather Richardson, Associate Professor, UMass Amherst, Leandro Vendruscolo, Staff Scientist, NIDA
    10. Circadian (SCN) circuits
    Colleen McClung, Professor, U. of Pittsburgh, Ryan Logan, Assistant Professor, U. of Pittsburgh

Product details

  • No. of pages: 450
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: December 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780128234532

About the Editor

Nicholas Gilpin

Dr Nicholas Gilpin completed his undergraduate training in Psychology at University of Texas at Austin, and his Ph.D. in Psychobiology at Indiana University-Purdue University at Indianapolis. During graduate training, he worked with genetic models of susceptibility to alcoholism. He went on to complete a post-doctoral fellowship in the labs of Drs. George Koob and Marisa Roberto at The Scripps Research Institute in La Jolla, CA, where he used behavioral pharmacology & electrophysiology techniques to explore neural and behavioral dysregulation associated with alcohol dependence. He remains interested in questions of addiction, and is especially interested in understanding why and how alcohol addiction is co-morbid with addiction to other drugs and other psychiatric conditions. His interests also include questions related to subpopulations of addicts and individual differences in propensity to consume alcohol and drugs.

Affiliations and Expertise

LSU Health Sciences Center, USA

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