Neurochemistry of the Retina

Neurochemistry of the Retina

Proceedings of the International Symposium on the Neurochemistry of the Retina Held in Athens, Greece, August 28 - September 1, 1979

1st Edition - January 1, 1980

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  • Editors: Nicolas G. Bazan, Richard N. Lolley
  • eBook ISBN: 9781483189543

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Neurochemistry of the Retina covers the proceedings of the International Symposium on the Neurochemistry of the Retina held in Athens, Greece, on August 28 – September 1, 1979. This book mainly focuses on the retina and its neurochemistry. This text is divided into eight major parts. The first part discusses the composition, metabolism, and biogenesis of membrane components. This book then explains the biochemical approaches to the study of visual cells and their relationship with the pigment epithelium, photorector shedding, and circadian rhythm. Chemical transmission of nerve signals is also tackled. This text also looks into the biochemical aspects of photoreceptor structure and function; cyclic nucleotides; and biochemical and pharmacological approaches to study the entire retina. This book concludes by explaining the neurochemical studies in retinal diseases and future research and prospective of the subject. This publication will be invaluable to ophthalmologists and students of ophthalmology.

Table of Contents

  • I. Composition, Metabolism and Biogenesis of Membrane Components

    Transverse Distribution of Phospholipids in the Vertebrate Photo Receptor Membrane

    Biosynthesis of Membrane Lipids in the Retina: Sub-cellular Distribution and Propranolol Action on Phosphatidic Acid, Phosphatidylserine and Phosphatidylethanolamine

    Synthesis and Turnover of Lipid and Protein Components of Frog Retinal Rod Outer Segments

    The Gangliosides of the Chicken Retina and Optic Tectum. The Influence of Light on their Labeling after an Injection of Labeled Precursors

    The Lipid Intermediate Pathway in the Retina for the Activation of Carbohydrates Involved in the Glycosylation of Rhodopsin

    II. Biochemical Approaches to the Study of Visual Cells and their Relationship with the Pigment Epithelium, Photoreceptor Shedding and Circadian Rhythm

    Electrophysiological Responses Related to the Pigment Epithelium and its Interaction with the Receptor Layer

    Control of Rod Shedding in the Frog Retina

    Retinal Development: Time and Order of Appearance of Specific Neuronal Properties

    Cyclic Metabolism of Photoreceptors and Retinal Pigment Epithelium in the Frog

    An Hypothesis for a Vitamin A Cycle in the Pigment Epithelium of Bovine Retina

    The Chemistry of the Retina: Function, Renewal, Rhythms and the Nucleus

    III. Chemical Transmission of Nerve Signals. Localization, Metabolism and Function of Neurotransmitters

    Studies on Putative Neurotransmitters in the Distal Retina

    The Localization and Metabolism of Glutamate, Aspartate and GABA in the Rat Retina

    GABA and Dopamine Receptor Binding in Retinal Synaptosomal Fractions

    Retinal Organization: Neurotransmitters as Physiological Probes

    The Release of Acetylcholine and Amino Acids from the Rabbit Retina In Vivo

    Retinal Indoleamine Accumulating Neurons

    IV. Biochemical Aspects of Photoreceptor Structure and Function

    The Partial Primary Structure of Bovine Rhodopsin and its Topography in the Retinal Rod Cell Disc Membrane

    The Oligosaccharide Moiety of Rhodopsin — Its Structure and Cellular Location

    Lectins as Probes of Glycoprotein and Glycolipid Oligosaccharides in Rods and Cones

    Light-induced, Reversible Binding of Proteins to Bovine Photoreceptor Membranes. Influence of Nucleotides

    Rhodopsin Phosphorylation in the Frog Retina: Analysis by Autoradiography

    Search for a Physiological Role of Cyclic GMP Metabolism in the Photoreceptors

    V. Cyclic Nucleotides

    Localization and Roles of Cyclic Nucleotide Systems in Retina

    Cyclic Nucleotides in Rod- and Cone-dominant Retinas

    VI. Biochemical and Pharmacological Approaches to Study the Entire Retina

    The Isolated Retina of Mammals: A Useful Preparation for Enzymatic (Adenylyl Cyclase) and/or Binding Studies of Dopamine Receptors

    ERG Alterations Induced by Sound

    The Action of Psychotropic Drugs on Adenylate Cyclases and Phosphodiesterases in the Rat Retina

    Composition and Biosynthesis of Molecular Species of Retina Phosphoglycerides

    Synthesis and Breakdown of Different Sized Retinal Proteins in Darkness and during Photic Stimulation

    VII. Neurochemical Studies in Retinal Diseases

    Morphological and Biochemical Abnormalities in a Model of Retinal Degeneration: Canine Ceroid-lipofuscinosis (CCL)

    Cyclic GMP Metabolic Defects in Inherited Disorders of RD Mice and RCS Rats

    Cyclic GMP Phosphodiesterase Activator: Involvement in a Dereditary Retinal Degeneration

    Gyrate Atrophy of the Retina and Choroid is an Inborn Error of Metabolism of Ornithine Aminotransferase

    Effects of Exogenous Gangliosides on the Pattern of Respiratory Enzymes in Experimental Diabetic Retinopathy in the Rat

    Biochemistry of Retinal Degeneration in Rats and Mice: A Short Review

    VIII. Future Research and Prospective from Neurochemical Studies of the Retina in Health and Disease

    The Retina as a Biochemical Model of Central Nervous System Regeneration

    Acetylcholine in the Retina

    Dopaminergic Mechanisms in the Carp Retina: Effects of Dopamine K+ and Light on Cyclic AMP Synthesis

    The Disk Membrane as Model for an Excitable Membrane

    List of Participants

    Authors Index

    Subject Index

Product details

  • No. of pages: 580
  • Language: English
  • Copyright: © Pergamon 1980
  • Published: January 1, 1980
  • Imprint: Pergamon
  • eBook ISBN: 9781483189543

About the Editors

Nicolas G. Bazan

Richard N. Lolley

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