Neurochemistry of the Retina

Proceedings of the International Symposium on the Neurochemistry of the Retina Held in Athens, Greece, August 28 - September 1, 1979

1st Edition - January 1, 1980
Editors: Nicolas G. Bazan, Richard N. Lolley
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 1 - 8 9 5 4 - 3

Neurochemistry of the Retina covers the proceedings of the International Symposium on the Neurochemistry of the Retina held in Athens, Greece, on August 28 – September 1, 1979.… Read more

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Neurochemistry of the Retina covers the proceedings of the International Symposium on the Neurochemistry of the Retina held in Athens, Greece, on August 28 – September 1, 1979. This book mainly focuses on the retina and its neurochemistry. This text is divided into eight major parts. The first part discusses the composition, metabolism, and biogenesis of membrane components. This book then explains the biochemical approaches to the study of visual cells and their relationship with the pigment epithelium, photorector shedding, and circadian rhythm. Chemical transmission of nerve signals is also tackled. This text also looks into the biochemical aspects of photoreceptor structure and function; cyclic nucleotides; and biochemical and pharmacological approaches to study the entire retina. This book concludes by explaining the neurochemical studies in retinal diseases and future research and prospective of the subject. This publication will be invaluable to ophthalmologists and students of ophthalmology.

I. Composition, Metabolism and Biogenesis of Membrane Components

Transverse Distribution of Phospholipids in the Vertebrate Photo Receptor Membrane

Biosynthesis of Membrane Lipids in the Retina: Sub-cellular Distribution and Propranolol Action on Phosphatidic Acid, Phosphatidylserine and Phosphatidylethanolamine

Synthesis and Turnover of Lipid and Protein Components of Frog Retinal Rod Outer Segments

The Gangliosides of the Chicken Retina and Optic Tectum. The Influence of Light on their Labeling after an Injection of Labeled Precursors

The Lipid Intermediate Pathway in the Retina for the Activation of Carbohydrates Involved in the Glycosylation of Rhodopsin

II. Biochemical Approaches to the Study of Visual Cells and their Relationship with the Pigment Epithelium, Photoreceptor Shedding and Circadian Rhythm

Electrophysiological Responses Related to the Pigment Epithelium and its Interaction with the Receptor Layer

Control of Rod Shedding in the Frog Retina

Retinal Development: Time and Order of Appearance of Specific Neuronal Properties

Cyclic Metabolism of Photoreceptors and Retinal Pigment Epithelium in the Frog

An Hypothesis for a Vitamin A Cycle in the Pigment Epithelium of Bovine Retina

The Chemistry of the Retina: Function, Renewal, Rhythms and the Nucleus

III. Chemical Transmission of Nerve Signals. Localization, Metabolism and Function of Neurotransmitters

Studies on Putative Neurotransmitters in the Distal Retina

The Localization and Metabolism of Glutamate, Aspartate and GABA in the Rat Retina

GABA and Dopamine Receptor Binding in Retinal Synaptosomal Fractions

Retinal Organization: Neurotransmitters as Physiological Probes

The Release of Acetylcholine and Amino Acids from the Rabbit Retina In Vivo

Retinal Indoleamine Accumulating Neurons

IV. Biochemical Aspects of Photoreceptor Structure and Function

The Partial Primary Structure of Bovine Rhodopsin and its Topography in the Retinal Rod Cell Disc Membrane

The Oligosaccharide Moiety of Rhodopsin — Its Structure and Cellular Location

Lectins as Probes of Glycoprotein and Glycolipid Oligosaccharides in Rods and Cones

Light-induced, Reversible Binding of Proteins to Bovine Photoreceptor Membranes. Influence of Nucleotides

Rhodopsin Phosphorylation in the Frog Retina: Analysis by Autoradiography

Search for a Physiological Role of Cyclic GMP Metabolism in the Photoreceptors

V. Cyclic Nucleotides

Localization and Roles of Cyclic Nucleotide Systems in Retina

Cyclic Nucleotides in Rod- and Cone-dominant Retinas

VI. Biochemical and Pharmacological Approaches to Study the Entire Retina

The Isolated Retina of Mammals: A Useful Preparation for Enzymatic (Adenylyl Cyclase) and/or Binding Studies of Dopamine Receptors

ERG Alterations Induced by Sound

The Action of Psychotropic Drugs on Adenylate Cyclases and Phosphodiesterases in the Rat Retina

Composition and Biosynthesis of Molecular Species of Retina Phosphoglycerides

Synthesis and Breakdown of Different Sized Retinal Proteins in Darkness and during Photic Stimulation

VII. Neurochemical Studies in Retinal Diseases

Morphological and Biochemical Abnormalities in a Model of Retinal Degeneration: Canine Ceroid-lipofuscinosis (CCL)

Cyclic GMP Metabolic Defects in Inherited Disorders of RD Mice and RCS Rats

Cyclic GMP Phosphodiesterase Activator: Involvement in a Dereditary Retinal Degeneration

Gyrate Atrophy of the Retina and Choroid is an Inborn Error of Metabolism of Ornithine Aminotransferase

Effects of Exogenous Gangliosides on the Pattern of Respiratory Enzymes in Experimental Diabetic Retinopathy in the Rat

Biochemistry of Retinal Degeneration in Rats and Mice: A Short Review

VIII. Future Research and Prospective from Neurochemical Studies of the Retina in Health and Disease

The Retina as a Biochemical Model of Central Nervous System Regeneration

Acetylcholine in the Retina

Dopaminergic Mechanisms in the Carp Retina: Effects of Dopamine K+ and Light on Cyclic AMP Synthesis

The Disk Membrane as Model for an Excitable Membrane

List of Participants

Authors Index

Subject Index