Neurobiology of the Placebo Effect Part A - 1st Edition - ISBN: 9780128143254

Neurobiology of the Placebo Effect Part A, Volume 138

1st Edition

Serial Volume Editors: Luana Colloca
Hardcover ISBN: 9780128143254
Imprint: Academic Press
Published Date: 1st May 2018
Page Count: 322
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Table of Contents

1. Placebo effects in the immune system
Manfred Schedlowski, Martin Hadamitzky, Sven Benson and Wiebke Sondermann
2. Pharmacological conditioning of the endocrine and immune system: Challenges and opportunities
Andrea Evers
3. Expectancy modulation of opioid neurotransmission
Marta Pecina and Jon-Kar Zubieta
4. Nocebo effects in visceral pain
Sigrid Elsenbruch and Franziska Labrenz
5. What is minimally required to elicit placebo effects?
Karin Jensen
6. Critical life functions: can placebo replace oxygen?
Fabrizio Benedetti, Diletta Barbiani and Eleonora Camerone
7. Conditioning as a higher-order cognitive phenomenon: Implications for placebo research
Jan De Houwer
8. Placebos without deception
Luana Colloca and Jeremy Howick
9. Response Expectancy and the Placebo Effect
Irving Kirsch
10. Expectancy focused psychotherapy
Winfried Rief, Bettina K. Doering and Julia A. Glombiew
11. Placebo and Psychotherapy: Differences, Similarities and Implications
Jens Gaab
12. Can knowledge of placebo and nocebo mechanisms help improve the RCT?
Lene Vase and Elisa Carlino


Neurobiology of the Placebo Effect, Part A, Volume 138 in the International Review of Neurobiology series, is the first of two volumes that provide the latest placebo studies in clinically relevant models. Placebo responses are not merely a psychological, but a complex psycho-neuro-biological process that requires activation of distinct brain areas. This book discusses current research and projects on the involved brain circuitry and neurotransmitter systems. Specific chapters cover such topics as pharmacological conditioning of the endocrine and immune system, expectancy modulation of opioid neurotransmission, nocebo effects in visceral pain, and conditioning as a higher-order cognitive phenomenon, amongst other topics.

Key Features

placebo effects, expectancy, cognition, clinical trials methods


Professionals, researchers, clinicians and students in the sector


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© Academic Press 2018
Academic Press
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About the Serial Volume Editors

Luana Colloca Serial Volume Editor

Dr. Luana Colloca is an associate professor at the School of Nursing and School of Medicine, University of Maryland and has extensive experience in the area of pain modulation and placebo effects. Luana received her MD degree from the University of Catanzaro, Medical School and holds both a master degree in Bioethics and a PhD in Neuroscience from the University of Turin in Italy. She completed a post-doc fellowship at the Karolinska Institute in Stockholm, Sweden and a senior research fellowship at the National Institute of Health. Luana's main line of research focuses on how expectations and learning mechanisms shape experience-driven placebo and nocebo effects. The goal of this research is to provide a comprehensive approach to understanding pain modulation and complex functions as such placebo and nocebo effects, incorporating behavioral, pharmacological, functional and psychophysical information directly in humans. The developed approaches are pivotal in translating knowledge about pain modulation from human laboratory settings to patient populations. Luana has authored numerous original articles - well-cited in the biomedical literature and published in journals such as Nature Neuro, JAMA, J Neuro, BMJ, and Pain. Prof. Colloca also co-edited three books for Elsevier, JHP, and Lambert Press respectively on the neurophysiological and translational aspects of the placebo and nocebo effects.

Affiliations and Expertise

School of Nursing, University of Maryland, Baltimore, USA