Neurobiology of Steroids

Neurobiology of Steroids

1st Edition - November 18, 1994

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  • Editor: Win Sutanto
  • eBook ISBN: 9781483288369

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Steroid hormones are unique compounds in that they are active at the interface of peripheral endocrine events and neural mechanisms. Thus their effects present an important peripheral signaling system to alter brain function. This volume presents state-of-the-art and classical techniques for the study of steroid hormones and their receptors and their effects and actions.

Key Features

@introbul:Key Features
Comprehensive protocols included for the study of
@bul:* Steroid kinetics and metabolism
* Steroid receptors
* Molecular and cellular effects of steroids
* Steroid effects on integrated systems


Neurobiologists, neurobiochemists, neuroendocrinologists, molecular biologists, endocrinologists, biochemists, biophysicists, and geneticists.

Table of Contents

  • Steroid Kinetics and Metabolism:
    W.M. Pardridge, Steroid Hormone Transport through the Blood-Brain Barrier: Methods and Concepts.
    J.W. Simpkins and N. Bodor, Enhanced Delivery of Steroids to the Brain Using a Redox-Based Chemical Delivery System.
    P. Robel and E.-E. Baulieu, Neurosteroids: Biosynthesis and Function.
    M. Warner, A. Wyss, S. Yoshida, and J. T. Gustafsson, Cytochrome P450 Enzymes in Brain.
    Z. Krozowski, Methods for Estimating 11b-Hydroxysteroid Dehydrogenase Activity.
    Steroid Receptors:
    A.D. van Haarst and T.F. Szuran, Steroid Hormone Binding to Intracellular Receptors: In Vitro and in Vivo Studies.
    M. Orchinik and T.F. Murray, Steroid Hormone Binding to Membrane Receptors.
    N.J. MacLusky, H. Yuan, D. Bowlby, R.B. Hochberg, and T.J. Brown, In Vitro Autoradiography for Steroid Receptors.
    A. Cintra, G. Akner, R. Covetas, M. de Leen, A.-C. Wikstrim, L.F. Agnati, J.T. Gustafsson, and K. Fuxe, Immunocytochemical Studies on Glucocorticoid Receptor.
    B. van Steensel, E.P. van Binnendijk, and R. van Driel, Confocal Scanning Laser Microscopy of Steroid Receptors in Brain.
    Z. Liposits and I. Kalle, Ultrastructural Aspects of Steroid Receptor Localization: Immunocytochemical Perspective.
    J.P. Herman, S.P. Kwak, and S.J. Watson, Hybridization Studies of Adrenocorticosteroid Receptors in the Central Nervous System.
    L.D. McCauley and K.W. Gee, Detection and Characterization of Epalon Receptors: Novel Recognition Sites for Neuroactive Steroids That Modulate the GABAA Receptor Complex.
    M. Karl, H.M. Schulte, and G.P. Chrousos, Mutation Analysis of Steroid Hormone Receptors.
    Molecular Effects of Steroids:
    Y.-s. Zhu andD.W. Pfaff, Protein-DNA-Binding Assay for Analysis of Steroid-Sensitive Neurons in Mammalian Brain.
    K. Damm, Gene Transfection Studies Using Recombinant Steroid Receptors.
    J.J. Cox, S.L. da Silva, W. Hendriks, and J.P.H. Burbach, Regulation of Neuropeptide Genes: Determination of Responsiveness to Steroids and Identification of Receptors in Brain Nuclei.
    N.R. Nichols, J.N. Masters, and C.E. Finch, Cloning of Steroid-Responsive mRNAs by Differential Hybridization.
    S.M. Nair and J.H. Eberwine, Molecular Correlates of Corticosterone Action in Hippocampal Subregions.
    L.A. Dokas, Glucocorticoid-Determined Protein Synthesis.
    M.M. McCarthy, Use of Antisense Oligodeoxynucleotides to Block Gene Expression in Central Nervous System.
    Cellular Effects of Steroids:
    E.C. Azmitia and X.P. Hou, Steroid Regulation of Neuronotrophic Activity: Primary Microcultures of Midbrain Raphe and Hippocampus.
    K. Fuxe, A. Cintra, R. Diaz, G. Chadi, J. T. Gustafsson , and L.F. Agnati, Central Glucocorticoid Receptors and Neuronal Plasticity.
    C.S. Woolley and E. Gould, Steroid Action on Neuronal Structure.
    C. Leranth, F. Naftolin, M. Shanabrough, and T.L. Horvath, Electron Microscopic Double and Triple Labeling Immunocytochemistry in Elucidation of Synaptological Interactions between Ovarian Steroid-Sensitive Neurons and Circuits.
    M. Jools, Gene-Mediated Steroid Control of Neuronal Activity.
    C. Hill-Venning, D. Belelli, J.A. Peters, and J.J. Lambert, Electrophysiological Studies of Neurosteroid Modulation of (-Aminobutyric Acid Type A Receptor.
    M.C. Bohn, In Vitro Approaches to Studying Glucocorticoid Effects on Gene Expression in Neurons and Glia.
    Steroid Effects on Integrated Systems:
    M.S. Oitzl, Behavioral Approaches to Study Function of Corticosteroids in Brain.
    E.P. Gomez-Sanchez, Adrenocorticosteroids and Cardiovascular Regulation: Methods for Surgery and Blood Pressure Measurements.
    B. Schibitz, Steroids and Central Regulation of Immune Response.
    B.S McEwen, Steroid Hormone Effects on Brain: Novel Insights Connecting Cellular and Molecular Features of Brain Cells to Behavior.

Product details

  • No. of pages: 552
  • Language: English
  • Copyright: © Academic Press 1994
  • Published: November 18, 1994
  • Imprint: Academic Press
  • eBook ISBN: 9781483288369

About the Serial Volume Editor

Win Sutanto

Affiliations and Expertise

University of Leiden, Sylvius Laboratories, The Netherlands

About the Editor in Chief

P. Michael Conn

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. Conn is a previous member of Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation and worked with political leadership to heighten the public’s awareness of diabetes. Conn’s students and fellows have gone on to become leaders in industry and academia. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science. He is the co-author of The Animal Research War (2008) and many articles for the public and academic community on the value of animal research and the dangers posed by animal extremism. His op/eds have appeared in The Washington Post, The LA Times, The Wall Street Journal, the Des Moines Register, and elsewhere. Conn consults with organizations that are influenced by animal extremism and with universities and companies facing challenges from these groups.

Affiliations and Expertise

Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center, TX, USA

About the Editor

E. de Kloet

Affiliations and Expertise

Center for Bio-Pharmaceutical Sciences, Leiden/Amsterdam Center for Drug Research, University of Lei

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