Neurobiology of Ischemic Brain Damage, Volume 96

1st Edition

Editors: K. Kogure K.-A. Hossmann B. Siesjö
Hardcover ISBN: 9780444896032
eBook ISBN: 9780080862217
Imprint: Elsevier Science
Published Date: 10th May 1993
Page Count: 282
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Table of Contents

List of Contributors. Preface. Chapter 1. A new perspective on ischemic brain damage (B.K. Siesjö). Section I. Temperature, Acid-Base Homeostasis, and Microcirculation. 2. Temperature modulation of ischemic brain injury - a synthesis of recent advances (M.D. Ginsberg, M.Y.-T. Globus, W. D. Dietrich, R. Busto). 3. Acidosis-related brain damage (B.K. Siesjö, K. Katsura, P. Mellergård, A. Ekholm, J. Lundgren, M.-L. Smith). 4. Cerebral ischemia: the microcirculation as trigger and target (U. Dirnagl). Section II - Free Radicals and Excitatory Amino Acids. 5. Evaluation of the concomitance of lipid peroxidation in experimental models of cerebral ischemia and stroke (B.D. Watson). 6. Role of superoxide dismutase in ischemic brain injury: reduction of edema and infarction in transgenic mice following focal cerebral ischemia (P.H. Chan, C.J. Epstein, H. Kinonchi, S. Imaizumi, E. Carlson and S.F. Chen). 7. Glutamate receptor transmission and ischemic nerve cell damage: Evidence for involvement of excitotoxic mechanisms (N.H. Diemer, E. Valente, T. Bruhn, M. Berg, M.B. Jorgenson, F.F. Johansen). 8. Antagonism of the NMDA and non-NMDA receptors in global versus focal brain ischemia (W. Pulsinelli, A. Sarokin, A. Buchan). 9. NMDA receptors and AMPA / kainate receptors mediate parallel injury in cerebral cortical cultures subjected to oxygen-glucose deprivation (D.W. Choi). Section III. Polyamine and Protein Metabolism. 10. Ischemia-induced disturbances of polyamine synthesis (W. Paschen, M. Cleef, G. Röhn, M. Müller, A.E.I. Pajunen). 11. Disturbances of cerebral protein synthesis and ischemic cell death (K.-A. Hossmann). 12. Protein phosphorylation and the regulation of mRNA translation following cerebral ischemia (T. Wieloch, K. Bergstedt, B.R. Hu). Section IV. Selective Gene Expression. 13. Stress protein and proto-oncogene expression as indicators of neuronal pathophysiology after i

Description

In the eight years since the publication of Volume 63 of Progress in Brain Research, on this subject, developments in the research field have been very fast. For example, receptor physiology and pharmacology is now an intensively studied field, and the excitotoxic hypothesis of cell death is commonly accepted. Furthermore, it is recognized that ischemia and other insults give rise to a sustained depression of overall protein synthesis, yet lead to the expression of dormant genes and to synthesis of new proteins.

In view of this development, this volume focusses on the cellular and molecular aspects of ischemic brain damage. The book will be of great value to all those interested in the pathophysiology of ischemic and traumatic brain damage.


Details

No. of pages:
282
Language:
English
Copyright:
© Elsevier Science 1993
Published:
Imprint:
Elsevier Science
eBook ISBN:
9780080862217
Hardcover ISBN:
9780444896032

Reviews

In the eight years since the publication of Volume 63 of Progress in Brain Research, on this subject, developments in the research field have been very fast. For example, receptor physiology and pharmacology is now an intensively studied field, and the excitotoxic hypothesis of cell death is commonly accepted. Furthermore, it is recognized that ischemia and other insults give rise to a sustained depression of overall protein synthesis, yet lead to the expression of dormant genes and to synthesis of new proteins.

In view of this development, this volume focusses on the cellular and molecular aspects of ischemic brain damage. The book will be of great value to all those interested in the pathophysiology of ischemic and traumatic brain damage.


About the Editors

K. Kogure Editor

Affiliations and Expertise

Institute of Brain Diseases, Sendai, Japan

K.-A. Hossmann Editor

Affiliations and Expertise

Max-Planck-Institute for Neurological Research, Cologne, Germany

B. Siesjö Editor

Affiliations and Expertise

University of Lund, Lund, Sweden