Neurobiology of Disease

1st Edition

Print ISBN: 9780120885923
eBook ISBN: 9780080466385
Imprint: Academic Press
Published Date: 2nd November 2006
Page Count: 1104
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This book is aimed at any basic scientist or clinician scientist teaching a course or conducting research on the basic science underlying the major neurological diseases. It provides an excellent overview of cutting-edge research on the fundamental disorders of the nervous system, including physiological and molecular aspects of dysfunction. The major categories of neurological disease are covered, and the chapters provide specific information about particular diseases exemplifying each of these categories. Sufficient clinical information is included to put into perspective the basic mechanisms discussed. The book assembles a world-class team of section editors and chapters written by acknowledged experts in their respective fields.

Key Features

  • Provides cutting edge information about fundamental mechanisms underlying neurological diseases
  • Amply supplied with tables, illustrations and references
  • Includes supporting clinical information putting the mechanisms of disease into perspective


Scientists and researchers in neuroscience, neurology, neurosurgery, psychiatry, physical medicine and rehabilitation, as well as graduate students and fellows preparing for board examinations.

Table of Contents

Part I. Central Nervous System

Section A. Metabolic Diseases – Hugo W. Moser

Chapter 1: Leukodystrophies Chapter 2: Lysosomal Disorders of the Nervous System Chapter 3: The Neurobiology of Peroxisomal Disorders Chapter 4: Creatine Deficiency Syndromes

Section B. Neurodegenerative Disorders – Gregor Wenning

Chapter 5: Parkinson’s Disease Chapter 6: Alzheimer Disease Chapter 7: Multiple System Atrophy Chapter 8: Olivopontocerebellar Atrophy (OPCA) Chapter 9: Neurobiology of Progressive Supranuclear Palsy

Section C. Genetic Diseases – Christopher Gomez

Chapter 10: Protein Aggregation Disorders Chapter 11: RNA-Based Disorders of Muscle and Brain Chapter 12: Ion Channel Disorders Chapter 13: Spinocerebellar Ataxia Type 1 Chapter 14: Shared Transcriptional Consequences of Mitochondrial Disease, Ischemic Hypoxia and Chemical Hypoxia

Section D. Neuroimmunological Disorders – Anthony T. Reder

Chapter 15: Paraneoplastic Neurological Disorders Chapter 16: Systemic Lupus Erythematosus: Descriptive Past and Mechanistic Future Chapter 17: Progressive Multifocal Leukoencephalopathy Chapter 18: Multiple Sclerosis Chapter 19: Immune-Mediated Neuropathies Chapter 20: Hashimoto Encephalopathy

Section E. Cerebrovascular Diseases – Lewis Morgenstern

Chapter 21: Vascular Cognitive Impairment Chapter 22: Cardioembolism Chapter 23: Coagulation Disorders Chapter 24: Clinical and Neurobiological Aspects of Stroke Recovery
Chapter 25: Non-Atheroscleroti


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© Academic Press 2007
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"I think [the book] is very valuable, and it has benefited from careful editing and good organization. ...The illustrations are excellent — color has been used judiciously and effectively. ...The number of undergraduate neuroscience majors is growing, and a book of this type could be of great value to them. Neurology residents would find it a very quick way to get the background on which to superimpose new findings. ...Overall, I think the book does achieve the goals that Gilman proposed — he and his colleagues are to be congratulated." -Guy McKhann, MD, Johns Hopkins University in the NEW ENGLAND JOURNAL OF MEDICINE, May 30, 2007