Neurobiology of Disease

Neurobiology of Disease

1st Edition - November 2, 2006

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  • Editor-in-Chief: Sid Gilman
  • Hardcover ISBN: 9780120885923
  • eBook ISBN: 9780080466385

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Neurobiology of Disease is aimed at any basic scientist or clinician scientist teaching a course or conducting research on the basic science underlying the major neurological diseases. It provides an excellent overview of cutting-edge research on the fundamental disorders of the nervous system, including physiological and molecular aspects of dysfunction. The major categories of neurological disease are covered, and the chapters provide specific information about particular diseases exemplifying each of these categories. Sufficient clinical information is included to put into perspective the basic mechanisms discussed. The book assembles a world-class team of section editors and chapters written by acknowledged experts in their respective fields.

Key Features

  • Provides cutting edge information about fundamental mechanisms underlying neurological diseases
  • Amply supplied with tables, illustrations and references
  • Includes supporting clinical information putting the mechanisms of disease into perspective


Scientists and researchers in neuroscience, neurology, neurosurgery, psychiatry, physical medicine and rehabilitation, as well as graduate students and fellows preparing for board examinations.

Table of Contents

  • Part I. Central Nervous System

    Section A. Metabolic Diseases – Hugo W. Moser

    Chapter 1: Leukodystrophies
    Chapter 2: Lysosomal Disorders of the Nervous System
    Chapter 3: The Neurobiology of Peroxisomal Disorders
    Chapter 4: Creatine Deficiency Syndromes

    Section B. Neurodegenerative Disorders – Gregor Wenning

    Chapter 5: Parkinson’s Disease
    Chapter 6: Alzheimer Disease
    Chapter 7: Multiple System Atrophy
    Chapter 8: Olivopontocerebellar Atrophy (OPCA)
    Chapter 9: Neurobiology of Progressive Supranuclear Palsy

    Section C. Genetic Diseases – Christopher Gomez

    Chapter 10: Protein Aggregation Disorders
    Chapter 11: RNA-Based Disorders of Muscle and Brain
    Chapter 12: Ion Channel Disorders
    Chapter 13: Spinocerebellar Ataxia Type 1
    Chapter 14: Shared Transcriptional Consequences of Mitochondrial Disease, Ischemic Hypoxia and Chemical Hypoxia

    Section D. Neuroimmunological Disorders – Anthony T. Reder

    Chapter 15: Paraneoplastic Neurological Disorders
    Chapter 16: Systemic Lupus Erythematosus: Descriptive Past and Mechanistic Future
    Chapter 17: Progressive Multifocal Leukoencephalopathy
    Chapter 18: Multiple Sclerosis
    Chapter 19: Immune-Mediated Neuropathies
    Chapter 20: Hashimoto Encephalopathy

    Section E. Cerebrovascular Diseases – Lewis Morgenstern

    Chapter 21: Vascular Cognitive Impairment
    Chapter 22: Cardioembolism
    Chapter 23: Coagulation Disorders
    Chapter 24: Clinical and Neurobiological Aspects of Stroke Recovery
    Chapter 25: Non-Atherosclerotic Cerebral Vasculopathies
    Chapter 26: Subarachnoid Hemorrhage
    Chapter 27: Cerebral Ischemia: Molecular Mechanisms and Protective Therapies
    Chapter 28: Intracerebral Hemorrhage and Intraventricular Hemorrhage-Induced Brain Injury

    Section F. Paroxysmal Disorders – Timothy A. Pedley

    Chapter 29: Idiopathic Epilepsies
    Chapter 30: Paroxysmal Dyskinesia
    Chapter 31: Neurobiology of Myoclonus
    Chapter 32: Channelopathies of the Nervous System
    Chapter 33: Migraine
    Chapter 34: Temporal Lobe Epilepsy

    Section G. Neoplastic Diseases – John Laterra

    Chapter 35: CNS Metastases
    Robert J. Weil

    Chapter 36: Meningioma
    Katrin Lamszus, Christian Hagel, and Manfred Westphal

    Chapter 37: CNS Lymphoma
    Corresponding Author: Dr. Batchelor

    Chapter 38: Neurofibromatosis 1
    Linda Piersall and David H. Gutmann

    Chapter 39: Medulloblastoma and Primitive Neuroectodermal Tumors
    Said Elshihabi and James T. Rutka

    Chapter 40: Glioma
    Anders I. Persson, QiWen Fan, Joanna J. Phillips, and William A. Weiss

    Section H. Infectious Diseases – Richard T. Johnson

    Chapter 41: Bacterial & Fungal
    Chapter 42: Parasitic Infections
    Chapter 43: Prion Diseases
    Chapter 44: Central Nervous System Viral Infections: Clinical Aspects and Pathogenic Mechanisms

    Section I. Motor Neuron Diseases – Eva L. Feldman

    Chapter 45: Spinal Muscular Atrophy
    Chapter 46: Amyotrophic Lateral Sclerosis-Like Syndromes Associated with Malignancy
    Chapter 47: Amyotrophic Lateral Sclerosis (ALS): Idiopathic and Inherited
    Chapter 48: Hereditary Spastic Paraplegia and Primary Lateral Sclerosis
    Chapter 49: Poliomyelitis
    Chapter 50: Spinobulbar Muscular Atrophy (Kennedy’s Disease)

    Section J. Malformations and Developmental Disorders – Michael V. Johnston

    Chapter 51: Neurobiology of Genetic Mental Retardation
    Chapter 52: Cerebral Palsy
    Chapter 53: Autism
    Chapter 54: Neurobiology of Dyslexia
    Chapter 55: Neonatal Brain Injuries
    Chapter 56: Spina Bifida
    Chapter 57: Circuits to Synapses: The Pathophysiology of Tourette Syndrome
    Chapter 58: Attention Deficit Hyperactivity Disorder
    Chapter 59: Congenital Hydrocephalus

    Section K. Neurologic Manifestations of Medical Diseases – John J. Caronna

    Chapter 60: Hematological Disorders
    Chapter 61: Renal Disease
    Chapter 62: Diabetes and Endocrine Disorders
    Chapter 63: Mechanisms and Consequences of CNS Hypoxia
    Chapter 64: Gastroenterologic and Hepatic Diseases and Their Effects on CNS
    Chapter 65: Sarcoidosis

    Section L. Sleep Disorders – Emmanuel Mignot

    Chapter 66: REM Sleep Behavior Disorder
    Chapter 67: The Neurobiology of Narcolepsy and Hypersomnia
    Chapter 68: Restless Legs Syndrome and Periodic Leg Movement
    Chapter 69: Obstructive Sleep Apnea
    Chapter 70: The Neurobiology of Insomnia

    Section M. Substance Abuse and Basic Toxicology – John C. M. Brust

    Chapter 71: Organic Chemicals
    Chapter 72: Metals
    Chapter 73: Drug Addiction

    Section N. Imaging the Nervous System – John C. Mazziotta

    Chapter 74: Assessment of Neurobiological Diseases with Magnetic Resonance Spectroscopy
    Chapter 75: Magnetic Resonance Imaging
    Chapter 76: Neurovascular CT Angiography
    Chapter 77: PET Imaging in Parkinson's Disease and Other Neurodegenerative Disorders
    Chapter 78: Single Photon Emission Computed Tomography (SPECT)
    Chapter 79: Functional Magnetic Resonance Imaging (fMRI)

    Part II. Peripheral Nervous System

    Section O. Peripheral Neuropathies – James Russell

    Chapter 80: Diabetic and Metabolic Neuropathies
    Chapter 81: Aquired Inflammatory Demyelinating and Axonal Neuropathies
    Chapter 82: Toxic and Drug-Induced Neuropathies
    Chapter 83: Hereditary Neuropathies
    Chapter 84: Neurological Manifestations of Vasculitis
    Chapter 85: Neuropathies Associated with Infections

    Section P. Myopathies and neuromuscular junction disorders – Charles A. Thornton

    Chapter 86: The Muscular Dystrophies
    Chapter 87: Myasthenia Gravis and Myasthenic Syndromes
    Chapter 88: Myopathies and Neuromuscular Junction Disorders
    Chapter 89: Immunobiology of Autoimmune Inflammatory Myopathies

    Section Q. Autonomic Disorders – Phillip A. Low

    Chapter 90: Central Autonomic Network
    Chapter 91: Autonomic Neuropathies
    Chapter 92: Thermoregulation and its Disorders
    Chapter 93: Control of Blood Pressure-Normal and Abnormal

    Section R. Pain – Kenneth L. Casey

    Chapter 94: Neoplasm-Induced Pain
    Chapter 95: Pain Associated with the Autonomic Nervous System
    Chapter 96: Post-Herpetic Neuralgia
    Chapter 97: Central Post-Stroke Pain

Product details

  • No. of pages: 1104
  • Language: English
  • Copyright: © Academic Press 2006
  • Published: November 2, 2006
  • Imprint: Academic Press
  • Hardcover ISBN: 9780120885923
  • eBook ISBN: 9780080466385

About the Editor in Chief

Sid Gilman

Affiliations and Expertise

Department of Neurology, University of Michigan, Ann Arbor, MI, USA

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