Neurobiology of Bipolar Disorder

Neurobiology of Bipolar Disorder

Road to Novel Therapeutics

1st Edition - November 25, 2020

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  • Editors: Joao Quevedo, Andre Carvalho, Eduard Vieta
  • Paperback ISBN: 9780128191828
  • eBook ISBN: 9780128191835

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The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches.

Key Features

  • Aids readers in understanding bipolar disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations
  • Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments to novel therapeutics
  • Synthesizes a discussion of the cellular and molecular mechanisms underlying symptoms with clinical aspects of bipolar disorder


Advanced students and researchers in neuroscience, psychology, medicine, health sciences, and pharmacology

Table of Contents

  • 1. Tackling the heterogeneity of bipolar disorder in the era of the Research Domain Criteria (RDoC)
    2. The neurodevelopmental basis of Bipolar Disorder: Mechanisms and Implications
    3. The neuroprogressive nature of Bipolar Disorder: Mechanisms and Implications
    4. Immune mechanisms in Bipolar Disorder: evidence and implications
    5. Mitochondrial pathways in Bipolar Disorder: mechanisms and implications
    6. Neuro-oxidative and neuro-nitrosative mechanisms in bipolar disorder: evidence and implications
    7. Mechanisms underpinning neurocognitive dysfunction in bipolar disorder
    8. The evolution of animal models for bipolar disorder
    9. Alteration in Circadian rhythms in bipolar disorder: mechanisms and implications
    10. The genetics of bipolar disorder
    11. Pharmacogenomics of bipolar disorder
    12. Blood-brain barrier dysfunction as a pathophysiological mechanism of bipolar disorder
    13. Induced Pluripotent stem cells as tools for the investigation of the neurobiology of bipolar disorder
    14. Bipolar disorder as a gliopathy
    15. Molecular Imaging findings in Bipolar disorder
    16. Structural and functional neuroimaging findings in bipolar disorder
    17. Epigenetic mechanisms of bipolar disorder
    18. Bipolar disorder and cardiovascular dysfunction: mechanisms and implications
    19. At-risk mental states for bipolar disorder
    20. Stress, allostatic load and bipolar disorder: mechanisms and implications
    21. Bipolar disorder, obesity and metabolic disturbances: mechanisms and implications
    22. The gut-brain axis in bipolar disorder
    23. The hypothalamic-pituitary-adrenal axis in bipolar disorder
    24. Disturbed neuroplasticity pathways in bipolar disorder: mechanisms and implications
    25. Aberrations in intracellular signaling pathways in bipolar disorder
    26. The impact of early-life stress in the development and course of bipolar disorder: mechanisms and implications
    27. Bipolar disorder and accelerated aging: mechanisms and implications
    28. Suicidal behaviors in bipolar disorder
    29. Pediatric bipolar disorder
    30. Late-life bipolar disorder
    31. Biomarkers for Bipolar Disorder
    32. The mechanisms of action of lithium in bipolar disorder
    33. Is there a biosignature for lithium response in bipolar disorder? Evidence and implications
    34. Exercise as a treatment for bipolar disorder
    35. Non-invasive neuromodulatory approaches for bipolar disorder
    36. Novel therapeutic drug targets for bipolar disorder
    37. The treatment of bipolar disorder in the era of precision psychiatry: challenges and opportunities

Product details

  • No. of pages: 470
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: November 25, 2020
  • Imprint: Academic Press
  • Paperback ISBN: 9780128191828
  • eBook ISBN: 9780128191835

About the Editors

Joao Quevedo

Dr. João Luciano de Quevedo, MD, PhD is Professor of Psychiatry at the McGovern Medical School, The University of Texas Health Science Center at Houston, where he is Vice-Chair for Faculty Development and Outreach, Director of the Translational Psychiatry Program, and Director of the Treatment-Resistant Depression Clinic. Before moving to Houston, he was Dean at the University of Southern Santa Catarina Medical School, Criciúma, SC, Brazil, where he is still Adjunct Professor of Psychiatry. He is also Editor-in-Chief of the Brazilian Journal of Psychiatry, and Director of the Continuous Medical Education Program in Psychiatry (PROPSIQ) of the Brazilian Psychiatric Association. Dr. Quevedo’s research interest is the neurobiology of psychiatric disorders, particularly mood disorders, and he is a specialist in both unipolar and bipolar treatment-resistant depression. He is author of nearly 600 publications and 10 scientific books.

Affiliations and Expertise

Professor of Psychiatry at the McGovern Medical School, The University of Texas Health Science Center at Houston, TX, USA

Andre Carvalho

André F Carvalho is associate professor at the Department of Psychiatry at the University of Toronto and a clinician scientist at the Centre for Addiction and Mental Health (CAMH). He was elected member of the board of councilors of the International Society of Bipolar Disorders (2016-2017) and the vice-chair of the section of private practice psychiatry of the World Psychiatric Association (2015-2017). He sits on the editorial board of several international peer-reviewed journals, including Psychotherapy and Psychosomatics, and has served as a peer reviewer for several leading journals and funding agencies. He is an expert in mood disorders, psychiatric epidemiology, and evidence-based mental health. Dr. Carvalho is a sought after speaker in several national and international meetings, and is the author of over 300 publications.

Affiliations and Expertise

Associate Professor, Department of Psychiatry, Temerty Medical School, University of Toronto, Toronto, ON, Canada

Eduard Vieta

Eduard Vieta is Professor of Psychiatry at the University of Barcelona and Chair of the Department of Psychiatry and Psychology at the Hospital Clinic, where he also leads the Bipolar Disorders Program in Barcelona, Catalonia, Spain. The Bipolar Unit is one of the worldwide leaders in clinical care, teaching and research on bipolar disorder. Dr. Vieta is the current Director of the Bipolar Research Program at the Spanish Research Network on Mental Diseases (CIBERSAM), funded by the Spanish Ministry of Economy and Competitiveness. Professor Vieta has received several awards, including the Aristotle award (2005), the Mogens Schou award (2007), the Strategic Research award of the Spanish Society of Biological Psychiatry (2009), the Official College of Physicians award to Professional Excellence (2011) and the Colvin Price on Outstanding Achievement in Mood Disorders Research by the Brain and Behaviour Research Foundation (2012). He has made significant contributions to many of the published bipolar disorder treatment guidelines and has authored more than 500 original articles, 350 book chapters and 30 complete books. His H index is 66 and has over 16000 citations, which makes him the most cited scientist worldwide in the field of bipolar disorder over the last 5 years. Furthermore, he is on the editorial board of a range of international scientific journals and has served as invited professor at Harvard University and as neuroscience scientific advisor to the European Presidency.

Affiliations and Expertise

Professor of Psychiatry and Chair, University of Barcelona, Spain; Head of the Department of Psychiatry and Psychology at the Hospital Clinic and Scientific

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