Neurobiology of Autism

Neurobiology of Autism

1st Edition - November 27, 2013

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  • Editor: Genevieve Konopka
  • eBook ISBN: 9780124199613
  • Hardcover ISBN: 9780124187009

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Description

This volume in the International Review of Neurobiology is a comprehensive overview of the state-of-the-art research into autism pathophysiology. Its chapters cover a wide range of etiologies, from genetics and development to environmental factors. In addition, it discusses key cell and behavioral phenotypes, including cortical and cerebellar phenotypes, as well as language and motor outputs. Finally, this volume's chapters on gene expression in the brain describe how genes may be connected to phenotypes in autism.

Key Features

  • Broad coverage of genetic and cellular phenotypes in autism
  • Focused on basic research
  • Chapters primarily written by new investigators with a fresh perspective on the biological underpinnings of autism

Readership

Neuroscientists, psychologists, neurologists

Table of Contents

  • Series Page

    Contributors

    Preface: The Neurobiology of Autism: Integrating Genetics, Brain Development, Behavior, and the Environment

    Chapter One. Autism Spectrum Disorder and the Cerebellum

    Abstract

    1 Introduction

    2 Cerebellar Organization

    3 ASD Symptoms in Patients with Cerebellar Disorders

    4 Motor Impairment in Autistic Individuals

    5 Cerebellar Pathology in Autism

    6 Cerebellar Differences in Autism: Structural Neuroimaging

    7 Abnormal Cerebellar Activation in Autism

    8 Autoimmune Studies in ASD Implicating the Cerebellum

    9 Autism Genes in Mouse Cerebellar Development

    10 Cerebellar Phenotypes in Rodent Models of Autism

    11 Functional Evidence from Mouse Genetics

    12 Conclusions

    Acknowledgment

    References

    Chapter Two. Contribution of Long Noncoding RNAs to Autism Spectrum Disorder Risk

    Abstract

    1 Small ncRNA

    2 Long ncRNA

    3 LncRNA in Fundamental Genetic Mechanisms

    4 LncRNAs in Cancer

    5 LncRNAs in the Brain

    6 LncRNAs Contribute to ASD

    7 Conclusions

    References

    Chapter Three. Identifying Essential Cell Types and Circuits in Autism Spectrum Disorders

    Abstract

    1 Introduction to Cell Types and Autism Spectrum Disorder

    2 Genetics of ASD

    3 Brief Review of Rodent Behavioral Assays Relevant to ASD Symptoms

    4 ASD Models Involving Serotonergic Neurons

    5 ASD Models Involving GABAergic Interneurons

    6 ASD Models Involving the Cerebellum

    7 ASD Models Involving the Striatum

    8 Other Regions and Cell Types

    9 Conclusions

    Acknowledgments

    References

    Chapter Four. Connecting Signaling Pathways Underlying Communication to ASD Vulnerability

    Abstract

    1 Introduction

    2 Neuroanatomy of Communication Deficits in ASD

    3 Genes Linking Language to ASD

    4 Modeling Communication Phenotypes Using Animal Models

    5 Evolutionary Comparisons

    6 Conclusions and Future Directions

    Acknowledgments

    References

    Chapter Five. MET Receptor Tyrosine Kinase as an Autism Genetic Risk Factor

    Abstract

    1 Introduction

    2 MET Receptor Tyrosine Kinase-Mediated Signaling has a Pleiotropic Role in Multiple Organ Ontogenesis

    3 MET Signaling Plays a Role in a Large Number of Neurodevelopment Events

    4 MET Receptor Tyrosine Kinase Expression in the Developing Brain

    5 The Human MET Gene Emerges as a Prominent Autism Risk Factor

    6 Implication of MET Signaling in Neural Development and Functional Connectivity

    7 Concluding Remarks

    Acknowledgments

    References

    Chapter Six. Transcriptional Dysregulation of Neocortical Circuit Assembly in ASD

    Abstract

    1 Introduction

    2 Transcriptional Regulation of ASD-related Layer-Dependent Identity and Connectivity

    3 Discussion

    Acknowledgments

    References

    Further Reading

    Chapter Seven. Motor Skill in Autism Spectrum Disorders: A Subcortical View

    Abstract

    1 Why Study Motor Skill in Autism?

    2 Overview of Motor Skill Deficits

    3 Mapping Autism Motor Skill Findings into a Useful Framework

    4 Can We Intervene?

    5 Summary

    References

    Chapter Eight. Orchestration of Neurodevelopmental Programs by RBFOX1: Implications for Autism Spectrum Disorder

    Abstract

    1 Neurodevelopment and the RBFOX1 RNA Splicing Factor

    2 RBFOX1 Genetic Variation and Autism Spectrum Disorder

    3 The Contributions of RBFOX1 Model Systems to Molecular Pathogenesis

    4 A Model for the Dysregulation of RBFOX1 in Human Neurodevelopmental Disease

    Acknowledgments

    References

    Chapter Nine. Immune Dysregulation in Autism Spectrum Disorder

    Abstract

    1 Introduction: The Autism Spectrum

    2 Genetic and Environmental Contributions to ASD

    3 Immune Activation as a Primary Risk Factor for ASD

    4 Immune-Related Genetic Risk Factors for ASD

    5 Postnatal Immune Dysregulation in ASD

    6 Immune Contributions to ASD Pathogenesis

    7 Immune-Related Therapies for ASD

    8 Conclusion

    References

    Chapter Ten. Autism Susceptibility Genes and the Transcriptional Landscape of the Human Brain

    Abstract

    1 Introduction

    2 ASD Susceptibility Genes

    3 ASD Brain Transcriptome Studies

    4 Transcriptional Properties of ASD Genes in the Normal Human Brain

    5 Conclusions and Further Directions

    Acknowledgments

    References

    Index

    Contents of Recent Volumes

Product details

  • No. of pages: 384
  • Language: English
  • Copyright: © Academic Press 2013
  • Published: November 27, 2013
  • Imprint: Academic Press
  • eBook ISBN: 9780124199613
  • Hardcover ISBN: 9780124187009

About the Serial Volume Editor

Genevieve Konopka

Affiliations and Expertise

Genevieve Konopka, Assistant Professor Department of Neuroscience University of Texas Southwestern Medical Center Dallas, TX, USA

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