Neurobiology of Autism, Volume 113

1st Edition

Serial Volume Editors: Genevieve Konopka
Hardcover ISBN: 9780124187009
eBook ISBN: 9780124199613
Imprint: Academic Press
Published Date: 1st December 2013
Page Count: 384
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Table of Contents

Series Page


Preface: The Neurobiology of Autism: Integrating Genetics, Brain Development, Behavior, and the Environment

Chapter One. Autism Spectrum Disorder and the Cerebellum


1 Introduction

2 Cerebellar Organization

3 ASD Symptoms in Patients with Cerebellar Disorders

4 Motor Impairment in Autistic Individuals

5 Cerebellar Pathology in Autism

6 Cerebellar Differences in Autism: Structural Neuroimaging

7 Abnormal Cerebellar Activation in Autism

8 Autoimmune Studies in ASD Implicating the Cerebellum

9 Autism Genes in Mouse Cerebellar Development

10 Cerebellar Phenotypes in Rodent Models of Autism

11 Functional Evidence from Mouse Genetics

12 Conclusions



Chapter Two. Contribution of Long Noncoding RNAs to Autism Spectrum Disorder Risk


1 Small ncRNA

2 Long ncRNA

3 LncRNA in Fundamental Genetic Mechanisms

4 LncRNAs in Cancer

5 LncRNAs in the Brain

6 LncRNAs Contribute to ASD

7 Conclusions


Chapter Three. Identifying Essential Cell Types and Circuits in Autism Spectrum Disorders


1 Introduction to Cell Types and Autism Spectrum Disorder

2 Genetics of ASD

3 Brief Review of Rodent Behavioral Assays Relevant to ASD Symptoms

4 ASD Models Involving Serotonergic Neurons

5 ASD Models Involving GABAergic Interneurons

6 ASD Models Involving the Cerebellum

7 ASD Models Involving the Striatum

8 Other Regions and Cell Types

9 Conclusions



Chapter Four. Connecting Signaling Pathways Underlying Communication to ASD Vulnerability


1 Introduction

2 Neuroanatomy of Communication Deficits in ASD

3 Genes Linking Lan


This volume in the International Review of Neurobiology is a comprehensive overview of the state-of-the-art research into autism pathophysiology. Its chapters cover a wide range of etiologies, from genetics and development to environmental factors. In addition, it discusses key cell and behavioral phenotypes, including cortical and cerebellar phenotypes, as well as language and motor outputs. Finally, this volume's chapters on gene expression in the brain describe how genes may be connected to phenotypes in autism.

Key Features

  • Broad coverage of genetic and cellular phenotypes in autism
  • Focused on basic research
  • Chapters primarily written by new investigators with a fresh perspective on the biological underpinnings of autism


Neuroscientists, psychologists, neurologists


No. of pages:
© Academic Press 2013
Academic Press
eBook ISBN:
Hardcover ISBN:

About the Serial Volume Editors

Genevieve Konopka Serial Volume Editor

Affiliations and Expertise

Genevieve Konopka, Assistant Professor Department of Neuroscience University of Texas Southwestern Medical Center Dallas, TX, USA