Description

This volume in the International Review of Neurobiology is a comprehensive overview of the state-of-the-art research into autism pathophysiology. Its chapters cover a wide range of etiologies, from genetics and development to environmental factors. In addition, it discusses key cell and behavioral phenotypes, including cortical and cerebellar phenotypes, as well as language and motor outputs. Finally, this volume's chapters on gene expression in the brain describe how genes may be connected to phenotypes in autism.

Key Features

  • Broad coverage of genetic and cellular phenotypes in autism
  • Focused on basic research
  • Chapters primarily written by new investigators with a fresh perspective on the biological underpinnings of autism

Readership

Neuroscientists, psychologists, neurologists

Table of Contents

Series Page

Contributors

Preface: The Neurobiology of Autism: Integrating Genetics, Brain Development, Behavior, and the Environment

Chapter One. Autism Spectrum Disorder and the Cerebellum

Abstract

1 Introduction

2 Cerebellar Organization

3 ASD Symptoms in Patients with Cerebellar Disorders

4 Motor Impairment in Autistic Individuals

5 Cerebellar Pathology in Autism

6 Cerebellar Differences in Autism: Structural Neuroimaging

7 Abnormal Cerebellar Activation in Autism

8 Autoimmune Studies in ASD Implicating the Cerebellum

9 Autism Genes in Mouse Cerebellar Development

10 Cerebellar Phenotypes in Rodent Models of Autism

11 Functional Evidence from Mouse Genetics

12 Conclusions

Acknowledgment

References

Chapter Two. Contribution of Long Noncoding RNAs to Autism Spectrum Disorder Risk

Abstract

1 Small ncRNA

2 Long ncRNA

3 LncRNA in Fundamental Genetic Mechanisms

4 LncRNAs in Cancer

5 LncRNAs in the Brain

6 LncRNAs Contribute to ASD

7 Conclusions

References

Chapter Three. Identifying Essential Cell Types and Circuits in Autism Spectrum Disorders

Abstract

1 Introduction to Cell Types and Autism Spectrum Disorder

2 Genetics of ASD

3 Brief Review of Rodent Behavioral Assays Relevant to ASD Symptoms

4 ASD Models Involving Serotonergic Neurons

5 ASD Models Involving GABAergic Interneurons

6 ASD Models Involving the Cerebellum

7 ASD Models Involving the Striatum

8 Other Regions and Cell Types

9 Conclusions

Acknowledgments

References

Chapter Four. Connecting Signaling Pathways Underlying Communication to ASD Vulnerability

Abstract

1 Introduction

2 Neuroanatomy of Communication Deficits in ASD

3 Genes Linking Lan

Details

No. of pages:
384
Language:
English
Copyright:
© 2013
Published:
Imprint:
Academic Press
Print ISBN:
9780124187009
Electronic ISBN:
9780124199613