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Neuro-Urology Research: A Comprehensive Overview describes the current status of the neuro-urology field, discusses potential future directions and explains the latest neuroscience tools that can be used in neuro-urology research. The first section provides an overview of the circuit-based interrogation of subcortical and spinal networks involved in bladder filling and voiding. The second section discusses the translational potential of research for patients including specific chapters on the sensation of bladder stretch, bladder pain, the effects of hormones and the potential results of neurodegeneration on bladder function. The third section compares traditional and current studies determining the need for addressing or readdressing principles or adjusting dogma. Section four introduces techniques including optogenetic manipulation and calcium imaging of neural activity, and on how these methods can be applied to neuro-urology research. The fifth and final section proposes studies in directions that have remained underexplored or otherwise controversial. Perfect for all currently researching neuro-urology, this detailed understanding of the cellular and synaptic circuits that control bladder filling and voiding and of the circuitry regulating bladder function, has the potential to inform the development of newer therapeutics for treating LUTS.
- Conveys the importance of a deeper understanding of the basis of the neural control of bladder function to bridge gap in understanding of the neuro-urology research field
- Stresses and highlights the importance of fundamental research before scientific results can be applied to clinical settings
- Includes cutting edge neuroscience techniques like (wireless/ radiofrequency) optogenetic manipulation of cell activity, and gene profiling
- Summarizes the outcomes of the latest research and overview of how new findings compare with more traditional studies and clear explanations of how neuro-urology research may be applicable to treating patients with LUTS
Urology researchers and Urologists. Neuroscientists interested in the neuro effects on urology
Research on neural circuits
1. Neural networks controlling bladder function
Translational effects of neuro-urology research on clinical practice
2. How can treatment of LUTS caused by altered detrusor activity, benefit from basic research
3. Bladder pain signaling/pathway
4. Patient population-specific LUTS
5. Hormonal effects on voiding
Neuroscience in urology research
6. Neuro-urology research from the 1920s to the early 2000s compared to neuro-urology research in the present
7. Pontine micturition center neuron subpopulations
8. Voluntary versus reflex control
9. Urology as readout for neuroscience research
Cutting edge/state of the art neuroscience tools applied to neuro-urology
10. Optogenetics, Neurolux system/wireless, ChR2-mouse lines and their application in neuro-urology research
11. Fiber photometry, imaging of neural activity, GCaMP6-mouse lines, and their application in neuro-urology research
12. Transcriptome profiling; comprehensively cataloging neuron subpopulations, their transcriptional markers, and the application in neuro-urology research
The future for the neuro-urology field
13. Midbrain periaqueductal gray (PAG), the bladder control command center
14. Neural control of continence
- No. of pages:
- © Academic Press 2022
- 1st February 2022
- Academic Press
- Paperback ISBN:
Dr. Verstegen has a broad background in research and with specific training in key areas of molecular and cellular biology, behavioral and systems neuroscience, and with expertise in stereotaxic surgery techniques, design and execution of experimental paradigms coupled with optogenetics, and mouse genetics. She graduated in Experimental and Clinical Neuroscience at Utrecht University (NL) and obtained a Ph.D. degree at the Italian Institute of Technology (IIT). Her current research projects aim to identify the neural networks that control urine storage and voiding. Because disturbances in the brain control of the bladder and sphincter can cause or contribute to LUTS, understanding these control circuits may lead to potential therapies. Besides unraveling and mapping the neural circuitry, she is interested in understanding which neuro-regulators are involved and in associating function with distinct neuron subpopulations in aspects of bladder control.
Experimental and Clinical Neuroscience, Utrecht University, The Netherlands
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