Proceedings of the 11th Congress of the Collegium Internationale Neuro-Psychopharmacologicum, Vienna, July 9-14, 1978

1st Edition - January 1, 1979

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  • Editors: B. Saletu, P. Berner, L. Hollister
  • eBook ISBN: 9781483159775

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Neuro-psychopharmacology covers the proceedings of the 11th Congress of the Collegium Internationale Neuro-psychopharmacologicum, held in Vienna on July 9-14, 1978. The book focuses on the processes, methodologies, and approaches in neuropsychopharmacology. The selection first offers information on the long-lasting effects of electroconvulsive therapy (ECT) on monoaminergic mechanisms and enhanced monoamine behavioral responses following repeated electroconvulsive shock to rats and their relevance to ECT. The book also underscores the ECT effects on mineral metabolism and neuroendocrine function. The publication reviews the genetic components in the mechanism of action of lithium; genetics and lithium ion metabolism in affective disorders; and pharmacogenetics and the pharmacologic challenge strategy in clinical research. The text also examines the influence of peptides in affective disorders and HLA antigens in affective disorders and cycloid psychoses. Discussions also focus on the biological and clinical basis of the therapeutic effects of benzodiazepines; effects of benzodiazepines on the electrical activity of the central nervous system; and diazepam metabolism in healthy subjects and patients with heart failure, renal failure, and hepatic cirrhosis. The selection is a dependable reference for readers interested in neuropsychopharmacology.

Table of Contents

  • List of CINP Committees


    Presidential Addres

    ECT in Depression: Biochemical Effects and Mode of Action


    Long Lasting Effects of ECT on Monoaminergic Mechanisms

    Enhanced Monoamine Behavioural Responses Following Repeated Electro convulsive Shock to Rats and their Relevance to ECT

    Convulsive Therapy in Depression: A Neurohumoral and Neuroendocrine Theory

    Genetic Aspects of Psychopharmacology

    The HLA System and the Gelinical Responseto Treatment with Haloperidol

    Genetic Components in the Mechanism of Action of Lithium: HLA-Antigens and the Response to Prophylactic Lithium

    Genetics and Lithium Ion Metabolism in Affective Disorders

    Pharmacogenetics and the Pharmacologic Challenge Strategy in Clinical Research: Studies of D-Amphetamine and Arecoline

    Functional Activitiy of Brain Monoamine Oxidase

    Biochemical Genetics and Platelet MAO

    Biological Research in Depression and Mania

    Serotonin in Depressive Illness - Studies of CSF 5-HIAA

    Obsessive-Compulsive Disorders: A Serotonergic Hypothesis

    The Case for Involvement of Dopamine in Depression and Mania

    Peptides in Affective Disorders: A Review

    Biogenic Amine Metabolites in Cerebro-spinal Fluid of Patients with Affective Disorders

    Adenylate Cyclase and the Mechanism of Lithium Action

    An Appraisal of Clinical Studies on the Dopaminergic Hypothesis of Depression

    HLA Antigens in Affective Disorders

    HLA Antigens in Affective Disorders and Cycloid Psychoses

    HLA-Antigens in Manic-Melancholic Disorders

    The HLA System as a Possible Marker for Psychiatric Disorders

    Diurnal Rhythms in Manic-Depressive Disorders

    48-Hour-Cycles of Depression and their Biological Concomitants with and without 'Zeitgebers'. A Case Report

    Chronobiological Aspects of Manic-Melancholic Disorders

    A New Classification of the Affective Disorders

    Endocrinological and Biochemical Peripheral Markers as an Index of Central Neurochemical Modifications

    General Survey of the Possible Correlations Between Psychiatric Disorders and Biological Modifications

    Blood Platelets as a Model for Brain Neurones: Relevance to Psychiatric Disorders and Mental Abnormalities

    Measurement of Neuro-Transmitter Metabolites in Blood, Urine and CSF in Psychiatric Patients

    Endocrinological and Peptide Modifications in Psychiatric Illness

    Concluding Remarks

    Diagnostic and Pharmacotherapeutic Aspects of Child Psychiatry

    Neuropsychopharmacology of Hyperkinetic Children

    Neuropsychopharmacology of Childhood Psychoses

    Neurophysiology and Child Psychiatry

    Part VI: The Relevance of Quantitative EEG and Sleep Investigations

    EEG Effects of Clozapine: Assocation or Dissocation of EEG and Behavior?

    Acute Efficacy of 20 Psychotropic Drugs on Human EEG Power Spectrum Variables Shown by Multivariate and Univariate Statistics

    Strategy of Statistical Spectral Analysis in Drug Studies. A Methodological Synopsis

    Drawing Inferences about the Therapeutic Efficacy of Drugs in Patients from their CNS Effect in Normals: Comparative Quantitative Pharmaco-EEG and Clinical Investigations

    Chronospectrogram Analysis in the Assessment of Spontaneous and Druginduced Changes in Vigilance

    Quantitative EEG in Relation to Plasma Concentration During Treatment with Antiepileptic Drugs

    Naltrexone in Normal Men

    The Biological and Clinical Basis of theTherapeutic Effects of Benzodiazepines


    ACTH as a Mediator in Anxiety

    Effects of Benzodiazepines on the Electrical Activity of the Central Nervous System: Correlation with Synaptic Pharmacology

    Diazepam Metabolism in Healthy Subjects and Patients with Heart Failure, Renal Failure and Hepatic Cirrhosis

    The Differentiation Between Neurotic Depression and Anxiety and Drug Treatment

    The Phenomenological, Pharmacological and Psychophysiological Characteristics of Neurotic Outpatients to whom no Diagnosis has been Applied

    Biological and Psychopharmacological Predictors of Drug Response

    Prediction of Response to Anti-Anxiety Agents

    Provocative Pharmacological Agents for Psychiatric Diagnosis: Methylphenidate, Sodium Amobarbital and Physostigmine

    Neuropeptides and Psychiatry

    Summary of Symposium on 'Endorphins'

    Possible Function of β Endorphin

    Beta-Endorphin Modulates Cholinergic and GABA-ergic Neurotransmission

    Studies on a Possible Pathological Significance of Endorphins in Psychiatric Disorders

    Beta-Endorphins and Naloxone in Psychiatrie Patients: Clinical and Biological Effects

    The Interaction of Naloxone with Striatal Dopaminergic Mechanisms

    Biological Monitoring of Psychotropic Drugs Treatment

    Chairman's Introductory Remarks

    Pharmacokinetics and Pharmacodynamics of Haloperidol in Man

    Monitoring of Phenothiazine Plasma Levelsin Psychiatrie Patients

    Plasma Level Monitoring of Tricyclic Antidepressants: Usefulness and Limitations

    Biological Monitoring of Psychotropic Drug Treatment: Usefulness and Limitations

    Quantitative EEG, Drug Levels and Clinical Effects

    Concluding Remarks

    Circadian Rhythms and Psychotropic Drugs


    The Influence of Dopaminergic Mechanism on 24-Hour Temperature and Activity Rhythms in Rodents

    The Influnce of the 24-Hour Rhythm in Brain 5HT on Response to Tryptophan and NN-Diemethyltryptamine

    Chronobiology, A New Perspective for Biology and Medicine

    Circadian Susceptibility Rhythm to Neuroleptics

    Behavioral Effects of Indoleamine and Catecholamine Precursors

    Transmitter Precursor Loading - Uses and Limitations

    Behavioral Responses to L-Tryptophan and L-Dopa in Monoamine Oxidase Inhibitor Treated Rats

    Symposium on Behavioral Effects of Indoleamine and Gatecholamine Precusors: Summary

    Addiction: Drugs of Abuse

    Opiate Addiction - New Perspectives in Research

    Pharmacological Basis of Clinical Abuse of Sedative Drugs

    Reinforcement Mechanisms of Stimulant Drugs

    Present Use of Hallucinogens

    The Summaries of the Symposia: A Synthesis


Product details

  • No. of pages: 750
  • Language: English
  • Copyright: © Pergamon 1979
  • Published: January 1, 1979
  • Imprint: Pergamon
  • eBook ISBN: 9781483159775

About the Editors

B. Saletu

P. Berner

L. Hollister

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