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Neuro-Psychopharmacology - 1st Edition - ISBN: 9780080230894, 9781483159775


1st Edition

Proceedings of the 11th Congress of the Collegium Internationale Neuro-Psychopharmacologicum, Vienna, July 9-14, 1978

Editors: B. Saletu P. Berner L. Hollister
eBook ISBN: 9781483159775
Imprint: Pergamon
Published Date: 1st January 1979
Page Count: 750
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Neuro-psychopharmacology covers the proceedings of the 11th Congress of the Collegium Internationale Neuro-psychopharmacologicum, held in Vienna on July 9-14, 1978. The book focuses on the processes, methodologies, and approaches in neuropsychopharmacology. The selection first offers information on the long-lasting effects of electroconvulsive therapy (ECT) on monoaminergic mechanisms and enhanced monoamine behavioral responses following repeated electroconvulsive shock to rats and their relevance to ECT. The book also underscores the ECT effects on mineral metabolism and neuroendocrine function. The publication reviews the genetic components in the mechanism of action of lithium; genetics and lithium ion metabolism in affective disorders; and pharmacogenetics and the pharmacologic challenge strategy in clinical research. The text also examines the influence of peptides in affective disorders and HLA antigens in affective disorders and cycloid psychoses. Discussions also focus on the biological and clinical basis of the therapeutic effects of benzodiazepines; effects of benzodiazepines on the electrical activity of the central nervous system; and diazepam metabolism in healthy subjects and patients with heart failure, renal failure, and hepatic cirrhosis. The selection is a dependable reference for readers interested in neuropsychopharmacology.

Table of Contents

List of CINP Committees


Presidential Addres

ECT in Depression: Biochemical Effects and Mode of Action


Long Lasting Effects of ECT on Monoaminergic Mechanisms

Enhanced Monoamine Behavioural Responses Following Repeated Electro convulsive Shock to Rats and their Relevance to ECT

Convulsive Therapy in Depression: A Neurohumoral and Neuroendocrine Theory

Genetic Aspects of Psychopharmacology

The HLA System and the Gelinical Responseto Treatment with Haloperidol

Genetic Components in the Mechanism of Action of Lithium: HLA-Antigens and the Response to Prophylactic Lithium

Genetics and Lithium Ion Metabolism in Affective Disorders

Pharmacogenetics and the Pharmacologic Challenge Strategy in Clinical Research: Studies of D-Amphetamine and Arecoline

Functional Activitiy of Brain Monoamine Oxidase

Biochemical Genetics and Platelet MAO

Biological Research in Depression and Mania

Serotonin in Depressive Illness - Studies of CSF 5-HIAA

Obsessive-Compulsive Disorders: A Serotonergic Hypothesis

The Case for Involvement of Dopamine in Depression and Mania

Peptides in Affective Disorders: A Review

Biogenic Amine Metabolites in Cerebro-spinal Fluid of Patients with Affective Disorders

Adenylate Cyclase and the Mechanism of Lithium Action

An Appraisal of Clinical Studies on the Dopaminergic Hypothesis of Depression

HLA Antigens in Affective Disorders

HLA Antigens in Affective Disorders and Cycloid Psychoses

HLA-Antigens in Manic-Melancholic Disorders

The HLA System as a Possible Marker for Psychiatric Disorders

Diurnal Rhythms in Manic-Depressive Disorders

48-Hour-Cycles of Depression and their Biological Concomitants with and without 'Zeitgebers'. A Case Report

Chronobiological Aspects of Manic-Melancholic Disorders

A New Classification of the Affective Disorders

Endocrinological and Biochemical Peripheral Markers as an Index of Central Neurochemical Modifications

General Survey of the Possible Correlations Between Psychiatric Disorders and Biological Modifications

Blood Platelets as a Model for Brain Neurones: Relevance to Psychiatric Disorders and Mental Abnormalities

Measurement of Neuro-Transmitter Metabolites in Blood, Urine and CSF in Psychiatric Patients

Endocrinological and Peptide Modifications in Psychiatric Illness

Concluding Remarks

Diagnostic and Pharmacotherapeutic Aspects of Child Psychiatry

Neuropsychopharmacology of Hyperkinetic Children

Neuropsychopharmacology of Childhood Psychoses

Neurophysiology and Child Psychiatry

Part VI: The Relevance of Quantitative EEG and Sleep Investigations

EEG Effects of Clozapine: Assocation or Dissocation of EEG and Behavior?

Acute Efficacy of 20 Psychotropic Drugs on Human EEG Power Spectrum Variables Shown by Multivariate and Univariate Statistics

Strategy of Statistical Spectral Analysis in Drug Studies. A Methodological Synopsis

Drawing Inferences about the Therapeutic Efficacy of Drugs in Patients from their CNS Effect in Normals: Comparative Quantitative Pharmaco-EEG and Clinical Investigations

Chronospectrogram Analysis in the Assessment of Spontaneous and Druginduced Changes in Vigilance

Quantitative EEG in Relation to Plasma Concentration During Treatment with Antiepileptic Drugs

Naltrexone in Normal Men

The Biological and Clinical Basis of theTherapeutic Effects of Benzodiazepines


ACTH as a Mediator in Anxiety

Effects of Benzodiazepines on the Electrical Activity of the Central Nervous System: Correlation with Synaptic Pharmacology

Diazepam Metabolism in Healthy Subjects and Patients with Heart Failure, Renal Failure and Hepatic Cirrhosis

The Differentiation Between Neurotic Depression and Anxiety and Drug Treatment

The Phenomenological, Pharmacological and Psychophysiological Characteristics of Neurotic Outpatients to whom no Diagnosis has been Applied

Biological and Psychopharmacological Predictors of Drug Response

Prediction of Response to Anti-Anxiety Agents

Provocative Pharmacological Agents for Psychiatric Diagnosis: Methylphenidate, Sodium Amobarbital and Physostigmine

Neuropeptides and Psychiatry

Summary of Symposium on 'Endorphins'

Possible Function of β Endorphin

Beta-Endorphin Modulates Cholinergic and GABA-ergic Neurotransmission

Studies on a Possible Pathological Significance of Endorphins in Psychiatric Disorders

Beta-Endorphins and Naloxone in Psychiatrie Patients: Clinical and Biological Effects

The Interaction of Naloxone with Striatal Dopaminergic Mechanisms

Biological Monitoring of Psychotropic Drugs Treatment

Chairman's Introductory Remarks

Pharmacokinetics and Pharmacodynamics of Haloperidol in Man

Monitoring of Phenothiazine Plasma Levelsin Psychiatrie Patients

Plasma Level Monitoring of Tricyclic Antidepressants: Usefulness and Limitations

Biological Monitoring of Psychotropic Drug Treatment: Usefulness and Limitations

Quantitative EEG, Drug Levels and Clinical Effects

Concluding Remarks

Circadian Rhythms and Psychotropic Drugs


The Influence of Dopaminergic Mechanism on 24-Hour Temperature and Activity Rhythms in Rodents

The Influnce of the 24-Hour Rhythm in Brain 5HT on Response to Tryptophan and NN-Diemethyltryptamine

Chronobiology, A New Perspective for Biology and Medicine

Circadian Susceptibility Rhythm to Neuroleptics

Behavioral Effects of Indoleamine and Catecholamine Precursors

Transmitter Precursor Loading - Uses and Limitations

Behavioral Responses to L-Tryptophan and L-Dopa in Monoamine Oxidase Inhibitor Treated Rats

Symposium on Behavioral Effects of Indoleamine and Gatecholamine Precusors: Summary

Addiction: Drugs of Abuse

Opiate Addiction - New Perspectives in Research

Pharmacological Basis of Clinical Abuse of Sedative Drugs

Reinforcement Mechanisms of Stimulant Drugs

Present Use of Hallucinogens

The Summaries of the Symposia: A Synthesis



No. of pages:
© Pergamon 1979
1st January 1979
eBook ISBN:

About the Editors

B. Saletu

P. Berner

L. Hollister

Ratings and Reviews