Handbook of Clinical Neurology: Neuro-Oncology, Part II provides an overview of the most recent developments in the field of neuro-oncology, including new diagnostic imaging techniques, along with immunology, molecular biology, and clinical aspects of different types of tumors. It also considers management and new therapeutic strategies for tumors, such as gene therapy, radiation therapy, and molecularly targeted treatments. Divided into five sections encompassing 33 chapters, the book begins with a description of specific tumor types such as low-grade gliomas, anaplastic astrocytomas, and medulloblastoma and primitive neuroectodermal tumors, along with rare brain tumors like neurofibromatosis and other genetic syndromes. It then discusses tumors at special sites, from brainstem tumors to peripheral nerve tumors, tumors of the meninges, and optic, hypothalamic, and thalamic tumors. It also explains the neurological complications of systemic cancer and the adverse effects of some treatments. Clinicians and neuroscientists, as well as researchers who read this book, will gain a better understanding of the clinical features and management of the neurological manifestations of tumors.

Key Features

* Unique perspectives on advancements in the diagnosis and treatment of tumors of the nervous system
* An in-depth exploration of new strategies, including diagnostics, and gene and molecularly targeted therapies
* A state-of-the-art reference that summarizes the clinical features and management of the many neurological manifestations of tumors of the nervous system

Table of Contents

Foreword Preface Contributors Section 4 Specific tumor types     29. Low-grade gliomas     30. Anaplastic astrocytomas     31. Anaplastic oligodendroglial tumors     32. Glioblastoma     33. Gliomatosis cerebri     34. Primary central nervous system lymphoma     35. Medulloblastoma and primitive neuroectodermal tumors Section 5 Rare brain tumors     36. Ependymomas, neuronal and mixed neuronal–glial tumors, dysembroblastic neuroepithelial tumors, pleomorphic xanthoastrocytomas, and pilocytic astrocytomas     37. Neurofibromatosis and other genetic syndromes Section 6 Tumors at special sites     38. Brainstem tumors     39. Optic, hypothalamic, and thalamic tumors     40. Pineal parenchymal tumors, embryonal tumors, and germ cell tumors     41. Tumors of the cerebellopontine angle     42. Tumors of the meninges     43. The management of skull base tumors     44. Peripheral nerve tumors Section 7 Neurological complications of systemic cancer     45. General oncology and neurological complications     46. Neurological complications of solid tumors     47. Neurological complications of leukemia and lymphoma     48. Neurological complications in plasma cell dyscrasias     49. Brain metastases     50. Neoplastic meningitis     51. Spinal cord involvement     52. Neuromuscular complications     53. Neurovascular complications of solid tumors and hematological neoplasms     54. Infectious, metabolic, and endocrine complications     55. Central nervous system paraneoplastic disease     56. Paraneoplastic disorders of the peripheral nervous system Section 8 Complications from treatments     57. Complications of chemotherapy in neuro-oncology     58. Complications of radiotherapy to the central nervous system     59. Neurological complications of chemotherapy to the central nervous system     60. Neurological complications of chemotherapy to the peripheral nervous system     61. General and neurological complications of targeted therapy


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© 2012
Print ISBN:
Electronic ISBN:

About the editors

Wolfgang Grisold

Affiliations and Expertise

Head of Department, Neurologic Department and LBI for Neuro-Oncology, Kaiser Franz Josef Hospital, Vienna, Austria

Riccardo Soffietti

Affiliations and Expertise

Head, Division of Neuro-Oncology


"…an unparalleled reputation as the world's most comprehensive source of information in neurology...Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care.", April 24, 2013