Handbook of Clinical Neurology: Neuro-Oncology, Part I summarizes the present state of scientific and clinical knowledge in the field of neuro-oncology, including information related to diagnostic techniques such as imaging, along with immunology, molecular biology, and clinical aspects of tumors. Management and new therapeutic strategies for tumors, including gene therapy and molecularly targeted treatments, are also covered. Divided into eight sections encompassing 61 chapters, the book begins with an overview of the basic principles of tumors, including the epidemiology of primary central nervous system tumors, angiogenesis and invasion in cancer, the link between blood-brain barrier and brain edema, and the role of stem cells in gliomas. It proceeds with a discussion of diagnostic tools such as neuroimaging, the principles of tumor therapy such as radiotherapy and immunotherapy, and clinical trials in neuro-oncology. The reader is also introduced to specific tumor types such as low-grade gliomas, anaplastic astrocytomas, and medulloblastoma and primitive neuroectodermal tumors, along with rare brain tumors like neurofibromatosis and other genetic syndromes. Furthermore, the book explains the neurological complications of systemic cancer and complications from treatments. This volume will appeal to clinicians and neuroscientists as well as researchers who want to gain a better understanding of the clinical features and management of the neurological manifestations of tumors.

Key Features

* An invaluable resource that includes critical, in-depth insights into recent developments in neuro-oncology
* A fresh perspective on molecular biology, immunology, and other clinical aspects of tumors of the nervous system
* Extensive coverage of tumor management and new therapeutic strategies, including gene therapy and molecularly targeted treatments
* New tactics and therapies that will aid clinicians in their quest to provide optimal care for their neuro-oncological patients

Table of Contents

Foreword Preface Contributors Section 1 Basic principles     1. Epidemiology of primary central nervous system tumors     2. Molecular biology of brain tumors     3. Angiogenesis and invasion in cancer     4. Immunology of brain tumors     5. Blood–brain barrier and brain edema     6. Stem cells in gliomas Section 2 Diagnostic tools     7. Diagnostic neuropathology of tumors of the central nervous system     8. Neuroimaging     9. Functional imaging in brain surgery     10. Imaging brain tumors with PET, SPECT, and ultrasonography     11. CSF and laboratory analysis (tumor markers)     12. Electrophysiology and intraoperative neurophysiological monitoring     13. Evaluation and monitoring of peripheral nerve function     14. Evaluation of cognitive functions and quality of life Section 3 Principles of therapy     15. Principles of brain tumor surgery     16. Radiotherapy     17. Chemotherapy with cytotoxic and cytostatic agents in brain cancer     18. Molecularly targeted therapy in neuro-oncology     19. Inhibiting angiogenesis in malignant gliomas     20. Immunotherapy of brain tumors     21. Gene therapy     22. Chemotherapy for brain tumors with polymer drug delivery     23. Convection-enhanced delivery of therapeutic agents into the brain     24. Management of cognitive deficits and mood disturbance     25. Steroids and brain tumors     26. Seizure control in brain tumors     27. Cancer pain management and palliative care     28. Clinical trials in neuro-oncology Index


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© 2012
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Electronic ISBN:

About the editors

Wolfgang Grisold

Affiliations and Expertise

Head of Department, Neurologic Department and LBI for Neuro-Oncology, Kaiser Franz Josef Hospital, Vienna, Austria

Riccardo Soffietti

Affiliations and Expertise

Department of Neuroscience, Neuro-Oncology, University of Torino, Italy.