Nervous System Plasticity and Chronic Pain - 1st Edition - ISBN: 9780444505095, 9780080953625

Nervous System Plasticity and Chronic Pain, Volume 129

1st Edition

Editors: J. Sandkühler B. Bromm G.F. Gebhart
eBook ISBN: 9780080953625
Imprint: Elsevier Science
Published Date: 7th November 2000
Page Count: 562


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Table of Contents

List of contributors. Foreword. I. Molecular causes of chronic pain. 1. Sodium channels and the molecular pathophysiology of pain (T.R. Cummins, S.D. Dib-Hajj, J.A. Black and S.G. Waxman, West Haven, CT, USA). 2. Chemical mediators of pain due to tissue damage and ischemia (S.P. Eckert, S.P. Cook and E.W. McCleskey, Portland OR, USA). Nociceptor excitation by thermal sensitization - a hypothesis (P.W. Reeh and G. Pethö Erlangen, Germany and Pecs, Hungary). 4. Protein kinase subtypes involved in injury - induced nociception (A.B. Malmberg, Palo Alto, CA, USA). II. Synaptic mechanisms of hyperalgesia and allodynia. 5. Synaptic transmission and plasticity in the superficial dorsal horn (K.A. Moore, H. Baba and C.J. Woolf, Charleston, MA, USA). 6. Synaptic mechanisms of hyperalgesia (J. Sandkühler, J. Benrath, C. Brechtel, R. Ruscheweyh and B. Heinke, Heidelberg, Germany). 7. Silent glutamatergic synapses and long-term facilitation in spinal dorsal horn neurons (M. Zhuo, St. Louis, MO, USA). 8. Spinal dorsal horn synaptic plasticity: involvement of group I metabotropic glutamate receptors (G. Gerber, D.-H. Youn, C.H. Hsu and RandiĆ Ames, IA, USA). III. Long-term changes in the spinal nociceptive system. 9. The functional anatomy of lamina I and its role in post-stroke central pain (A.D. Graig, Phoenix, AZ, USA). 10. Long-term potentiation in single wide dynamic range neurons induced by noxious stimulation in intact and spinalized rats (F. Svendsen, K. Hole and A. Tølsen Bergen,Norway). 11. The role of spinal nitric oxide in the control of spontaneous pain following nociceptive input (U. Hoheisel and S. Mense, Heidelberg, Germany). 12. The role of high threshold calcium channels in spinal neuron hyperexcitability induced by knee inflammation (H.-G. Schaible, J. Nebe, V. Neugebauer, A. Ebersberger and H. Vanegas, Jena, Germany). 13. Neuroplasticity in the spinal cord of monoarthritic rats: from metabolic changes to the detection of interleukin-6 using mRNA differential display (A. Berthele, J. Schadrack, J.M. Casto-Lopes, B. Conrad, W. Zieglgänsberger, and T.R. Tölle, Munich, Germany and Porto, Portugal). 14. Central roles of nociceptin/orphanin FQ and nocistatin: allodynia as a model of neural plasticity (S. Ito, E. Okuda-Ashitaka, T. Imanishi and T. Minami, Osaka, Japan). 15. The biological role of galanin in normal and neuropathic states (B.J. Kerr, D. Wynick, S.W.N. Thompson and S.B. McMahon (London and Bristol, UK). 16. Plasticity in descending pain modulatory systems (A. Pertovaara, Turku, Finland). IV. Thalamic contribution to chronic pain. 17. Role of thalamus in pain (J.O. Dostrovsky, Toronto, ON, Canada). 18. Plasticity of pain-related neuronal activity in the human thalamus (F.A. Lenz, J.-I. Lee, I.M. Garonzik, L.H. Rowland, P.M. Dougherty and S.E. Hua, Baltimore, MD and Seoul, Korea). V. Imaging pain. 19. Concepts of pain mechanisms: the contribution of functional imaging of the human brain (K.L. Casey, Ann Arbor, MI, USA). 20. Cortex areas involved in the processing of normal and altered pain (B. Bromm, E. Scharein and C. Vahle-Hinz, Hamberg, Germany. 21. Regional brain oxygenation during phasic and tonic painful stimulation (C. Foster, R. Ringler and H.O. Handwerker (Erlangen, Germany). 22. The functional organization of the brain in chronic pain ( H. Flor, Mannheim, Germany). VI. Human and animal models of chronic pain. 23. Neuroplasticity and clinical pain (G. Carli, Siena, Italy). 24. Multiple mechanisms of secondary hyperalgesia (R.-D. Treede and M. Magerl, Mainz, Germany). 25. Referred pain as an indicator for neural plasticity (L. Arendt-Nielsen, R.J. Laursen and A.M. Drewes, Aalborg, Denmark). 26. Neurochemical plasticity in persistent inflammatory pain ( P. Honoré, P.M. Menning, S.D. Rogers, M.L. Nichols and P.W. Mantyh, Minneapolis, MN, USA). 27. Modelling the prolonged effects of neonatal pain (D. Alvares, C. Torsney, B. Beland, M. Reynolds and M. Fitzgerald (London, UK). 28. Role of sentized pelvic nerve afferents from the inflamed rat colon in the maintenance of visceral hyperalgesia (S.V. Coutinho, X. Su, J.N. Sengupta and G.F. Gebhart (Iowa City, IA, USA). 29. Cellular and neurochemical remodeling of the spinal cord in bone cancer pain (P. Honoré, M.J. Schwei, S.D. Rogers, J.L. Salak-Johnson, M.P. Finke, M.L. Ramnaraine, D.R. Clohisy and P.W. Mantyh, Minneapolis, MN, USA). 30. Altered spinal processing in animal models of radicular and neuropathic pain (E. Carstens, Davis, CA, USA). 31. Allodynia and hyperalgesia within dermatones caudel to a spinal cord injury in primates and rodents (C.J. Vierck, Jr. and A.R. Light, Gainesville, FL and Chapel Hill, NC, USA). 32. Pain following spinal cord injury: pathophysiology and central mechanisms (R.P. Yezierski, Miami, Fl, USA). 33. Sympathetic nervous system: contribution to chronic pain (W. Jänig and H.-J. Häbler, Kiel, Germany). VII. Prevention and treatment of chronic pain. 34. A role for the endogenous cannabinoid system in the peripheral control of pain initiation (A. Calignano, G. La Rana, P. Loubet-Lescoulié and D. Piomelli, (Naples, Italy and Irvine, CA, USA). 35. Cellular and molecular mechanisms of opioid action (S.L. Ingram, Portland, OR, USA). 36. Pre-emptive analgesia in postamputation pain: an update (T.S. Jensen and L. Nikolajsen, Aarhus, Denmark). 37. Pre-emptive analgesia and surgical pain (O.H.G. Wilder-Smith, Berne, Switzerland). 38. Attentional control of pain and the process of chronification (M. Hasenbring, Bochum, Germany).


The mechanisms underlying the various forms of neuropathic pain are explored by leading experts in the field. The reviews provide state-of-the-art knowledge in pain research from the molecular and cellular level up to imaging of pain in the human cortex and to the perception of pain. In a truly interdisciplinary approach pain researchers and pain therapists give insights into the latest developments in the field. Some symptoms of neuropathic pain can now be understood at the molecular level, e.g. by modifications in the subunit composition of sodium channels or by the molecular properties of the vanilloid receptor. Synaptic mechanisms similar to those involved in learning and memory formation have now been discovered in pain pathways and real-time images of brain activity in human patients give novel insights into the differential processing of sensory-discriminative versus emotional-aversive aspects of pain.
This volume also documents another remarkable achievement in pain research during the past decade: The development of a common language and the assimilation of scientific concepts across disciplines. When reading the contributions, it becomes clear that new concepts and ideas developed in one arena of pain research have had impact on concepts and hypotheses important to other fields of pain research. Much of the foundation on which future pain research will rest is described in this volume. Numerous cross-references between the chapters and a detailed subject index make this book highly accessible to the reader.


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© Elsevier Science 2000
Elsevier Science
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@from:P.J. Siddall @qu:...This is a high quality book which is an excellent resource for anyone who has an interest in pain medicine and neuroscience. It brings together the latest authoritative thinking on a defining concept in the way that we approach pain. ...I would highly recommend its purchase by libraries which serve either clinicians or scientists in this field. @source:Anaesthesia and Intensive Care

About the Editors

J. Sandkühler Editor

Affiliations and Expertise

Institute of Physiology and Pathophysiology, University of Heidelberg, 69120 Heidelberg, Germany

B. Bromm Editor

Affiliations and Expertise

Institute of Physiology, University Hospital Eppendorf, 20246 Hamburg, Germany

G.F. Gebhart Editor

Affiliations and Expertise

Department of Pharmacology, The University of Iowa College of Medicine, Iowa City, Iowa 52242, USA