Neonatal Respiratory Distress

Contributors

Foreword

Preface

Terminology

Contents of Volume I

I Clinical Aspects of Hyaline Membrane Disease


1 Historical Perspective: Past and Present Approaches to Therapy of Hyaline Membrane Disease

Text

References


2 Clinical Relevance of Pulmonary Surfactant

I. Introduction

II. The Clinical Physiology of Surfactant during Health

III. The History of the Discovery of Pulmonary Surfactant

IV. Hyaline Membrane Disease as a Model for Surfactant Deficiency

V. Lung Stability of Immature Lungs

VI. Role of Surfactant in Lung Liquid Balance

VII. Clinical Function Summary

References


3 Overview of Hyaline Membrane Disease

I. Introduction

II. Clinical Presentation

III. Diagnostic Criteria

IV. Differential Diagnosis

V. Consequences of Hyaline Membrane Disease

VI. Epidemiology

VII. Pathogenesis in Relationship to Pulmonary Surfactant Deficiency

VIII. Summary

References


4 Radiology of Hyaline Membrane Disease, Transient Tachypnea of the Newborn, and Bronchopulmonary Dysplasia

I. Radiographic Evaluation of the Infant Chest

II. Hyaline Membrane Disease

III. Transient Tachypnea of the Newborn

IV. Bronchopulmonary Dysplasia

References


5 Pulmonary Function Abnormalities in Hyaline Membrane Disease and Bronchopulmonary Dysplasia

I. Introduction

II. Clinical Evaluation of Pulmonary Function

III. Direct Assessment of Pulmonary Function

IV. Bronchopulmonary Dysplasia: Long-Term Pulmonary Function Sequel of HMD

References


6 Therapy of Hyaline Membrane Disease

I. Introduction

II. Supportive Care

III. Respiratory Management

IV. Maintenance and Recovery Phase

V. Perspective

References


7 Long-Term Consequences of Hyaline Membrane Disease

I. Introduction to Follow-Up Studies

II. General Observations

III. Neurologic Sequel

IV. Pulmonary Status of Children Surviving HMD

V. Summary and Conclusions

References

II Prevention of Hyaline Membrane Disease


8 Introduction to the Preventative Approach in Perinatal Care

I. Introduction

II. Need for Prevention of Hyaline Membrane Disease

III. Investigation of the Preventative Approach in Perinatology

References


9 Amniocentesis

I. Introduction

II. Indications

III. Technique

IV. Risks

V. Technical Complications

VI. Ultrasound

References


10 Prenatal Assessment of Fetal Lung Maturation: A Critical Review of Amniotic Fluid Phospholipid Tests

I. Introduction

II. Methodology

III. Clinical Interpretation

IV. Summary and Recommendations

References


11 Hormonal Aspects of Fetal Lung Development

I. Introduction

II. Effects of Administered Hormones

III. Physiologic Role of Endogenous Hormones

IV. Hormone Binding in Lung

References


12 The New Zealand Study of Antepartum Glucocorticoid Treatment

I. Introduction

II. Design

III. Findings

IV. Adverse Effects

V. Conclusions

VI. Implications

References


13 Design and Organization of a Multicenter Clinical Trial for the Study of Corticosteroid Effects on Human Lung Development

I. Background

II. Initiation and Conduct of the Study

III. Quality Control

IV. Summary of Advantages and Disadvantages of the Multicenter Approach

References


14 The NIH Multicenter Study and Miscellaneous Clinical Trials of Antenatal Corticosteroid Administration

I. Introduction and Objectives

II. Clinical Trials Using Antepartum Corticosteroids

III. The NIH Collaborative Study

IV. Summary

References


15 Current Recommendations for Use of Prenatal Corticosteroids Based on Assessment of the Risk-Benefit Relationship

Text

Index