Neonatal Respiratory Distress

Neonatal Respiratory Distress

1st Edition - January 1, 1982

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  • Editor: Philip M Farrell
  • eBook ISBN: 9781483269122

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Lung Development: Biological and Clinical Perspectives, Volume II: Neonatal Respiratory Distress is a collection of papers that addresses the needs of small infants who have respiratory diseases. This volume deals with fetal lung development with emphasis on hyaline membrane disease. This book also presents basic information on pulmonary surfactant in the clinical area, particularly in 1) diagnosis and movement of neonatal respiratory distress; 2) prenatal assessment of fetal lung maturity; and 3) prevention of hyaline membrane disease with corticosteroid therapy. One paper reviews the essential clinical aspects of hyaline membrane disease, while another paper discusses data of the physiology of surfactant from a patient with hyaline membrane disease. Another paper examines the radiology of hyaline membrane disease, transient tachypnea of the newborn, and bronchopulmonary dysplasia; this paper also describes the radiographic techniques to be applied on infants. Other papers cite a treatment using antepartum glucocorticoid, as well as other clinical trials involving antenatal corticosteroid. One paper proposes a design and organization of a multicenter clinical trial that will study the effects of corticosteroid in the development of the human lung. This book can prove useful for pediatricians, specialists in respiratory diseases, and researchers whose work involves cardiovascular medicine and radiology.

Table of Contents

  • Contributors




    Contents of Volume I

    I Clinical Aspects of Hyaline Membrane Disease

    1 Historical Perspective: Past and Present Approaches to Therapy of Hyaline Membrane Disease



    2 Clinical Relevance of Pulmonary Surfactant

    I. Introduction

    II. The Clinical Physiology of Surfactant during Health

    III. The History of the Discovery of Pulmonary Surfactant

    IV. Hyaline Membrane Disease as a Model for Surfactant Deficiency

    V. Lung Stability of Immature Lungs

    VI. Role of Surfactant in Lung Liquid Balance

    VII. Clinical Function Summary


    3 Overview of Hyaline Membrane Disease

    I. Introduction

    II. Clinical Presentation

    III. Diagnostic Criteria

    IV. Differential Diagnosis

    V. Consequences of Hyaline Membrane Disease

    VI. Epidemiology

    VII. Pathogenesis in Relationship to Pulmonary Surfactant Deficiency

    VIII. Summary


    4 Radiology of Hyaline Membrane Disease, Transient Tachypnea of the Newborn, and Bronchopulmonary Dysplasia

    I. Radiographic Evaluation of the Infant Chest

    II. Hyaline Membrane Disease

    III. Transient Tachypnea of the Newborn

    IV. Bronchopulmonary Dysplasia


    5 Pulmonary Function Abnormalities in Hyaline Membrane Disease and Bronchopulmonary Dysplasia

    I. Introduction

    II. Clinical Evaluation of Pulmonary Function

    III. Direct Assessment of Pulmonary Function

    IV. Bronchopulmonary Dysplasia: Long-Term Pulmonary Function Sequel of HMD


    6 Therapy of Hyaline Membrane Disease

    I. Introduction

    II. Supportive Care

    III. Respiratory Management

    IV. Maintenance and Recovery Phase

    V. Perspective


    7 Long-Term Consequences of Hyaline Membrane Disease

    I. Introduction to Follow-Up Studies

    II. General Observations

    III. Neurologic Sequel

    IV. Pulmonary Status of Children Surviving HMD

    V. Summary and Conclusions


    II Prevention of Hyaline Membrane Disease

    8 Introduction to the Preventative Approach in Perinatal Care

    I. Introduction

    II. Need for Prevention of Hyaline Membrane Disease

    III. Investigation of the Preventative Approach in Perinatology


    9 Amniocentesis

    I. Introduction

    II. Indications

    III. Technique

    IV. Risks

    V. Technical Complications

    VI. Ultrasound


    10 Prenatal Assessment of Fetal Lung Maturation: A Critical Review of Amniotic Fluid Phospholipid Tests

    I. Introduction

    II. Methodology

    III. Clinical Interpretation

    IV. Summary and Recommendations


    11 Hormonal Aspects of Fetal Lung Development

    I. Introduction

    II. Effects of Administered Hormones

    III. Physiologic Role of Endogenous Hormones

    IV. Hormone Binding in Lung


    12 The New Zealand Study of Antepartum Glucocorticoid Treatment

    I. Introduction

    II. Design

    III. Findings

    IV. Adverse Effects

    V. Conclusions

    VI. Implications


    13 Design and Organization of a Multicenter Clinical Trial for the Study of Corticosteroid Effects on Human Lung Development

    I. Background

    II. Initiation and Conduct of the Study

    III. Quality Control

    IV. Summary of Advantages and Disadvantages of the Multicenter Approach


    14 The NIH Multicenter Study and Miscellaneous Clinical Trials of Antenatal Corticosteroid Administration

    I. Introduction and Objectives

    II. Clinical Trials Using Antepartum Corticosteroids

    III. The NIH Collaborative Study

    IV. Summary


    15 Current Recommendations for Use of Prenatal Corticosteroids Based on Assessment of the Risk-Benefit Relationship



Product details

  • No. of pages: 334
  • Language: English
  • Copyright: © Academic Press 1982
  • Published: January 1, 1982
  • Imprint: Academic Press
  • eBook ISBN: 9781483269122

About the Editor

Philip M Farrell

Affiliations and Expertise

Robert Turell Professor in Medical Leadership Dean, University of Wisconsin Medical School Vice Chancellor for Medical Affairs

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