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Neonatal Respiratory Distress - 1st Edition - ISBN: 9780122497025, 9781483269122

Neonatal Respiratory Distress

1st Edition

Editor: Philip M Farrell
eBook ISBN: 9781483269122
Imprint: Academic Press
Published Date: 1st January 1982
Page Count: 334
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Lung Development: Biological and Clinical Perspectives, Volume II: Neonatal Respiratory Distress is a collection of papers that addresses the needs of small infants who have respiratory diseases. This volume deals with fetal lung development with emphasis on hyaline membrane disease. This book also presents basic information on pulmonary surfactant in the clinical area, particularly in 1) diagnosis and movement of neonatal respiratory distress; 2) prenatal assessment of fetal lung maturity; and 3) prevention of hyaline membrane disease with corticosteroid therapy. One paper reviews the essential clinical aspects of hyaline membrane disease, while another paper discusses data of the physiology of surfactant from a patient with hyaline membrane disease. Another paper examines the radiology of hyaline membrane disease, transient tachypnea of the newborn, and bronchopulmonary dysplasia; this paper also describes the radiographic techniques to be applied on infants. Other papers cite a treatment using antepartum glucocorticoid, as well as other clinical trials involving antenatal corticosteroid. One paper proposes a design and organization of a multicenter clinical trial that will study the effects of corticosteroid in the development of the human lung. This book can prove useful for pediatricians, specialists in respiratory diseases, and researchers whose work involves cardiovascular medicine and radiology.

Table of Contents





Contents of Volume I

I Clinical Aspects of Hyaline Membrane Disease

1 Historical Perspective: Past and Present Approaches to Therapy of Hyaline Membrane Disease



2 Clinical Relevance of Pulmonary Surfactant

I. Introduction

II. The Clinical Physiology of Surfactant during Health

III. The History of the Discovery of Pulmonary Surfactant

IV. Hyaline Membrane Disease as a Model for Surfactant Deficiency

V. Lung Stability of Immature Lungs

VI. Role of Surfactant in Lung Liquid Balance

VII. Clinical Function Summary


3 Overview of Hyaline Membrane Disease

I. Introduction

II. Clinical Presentation

III. Diagnostic Criteria

IV. Differential Diagnosis

V. Consequences of Hyaline Membrane Disease

VI. Epidemiology

VII. Pathogenesis in Relationship to Pulmonary Surfactant Deficiency

VIII. Summary


4 Radiology of Hyaline Membrane Disease, Transient Tachypnea of the Newborn, and Bronchopulmonary Dysplasia

I. Radiographic Evaluation of the Infant Chest

II. Hyaline Membrane Disease

III. Transient Tachypnea of the Newborn

IV. Bronchopulmonary Dysplasia


5 Pulmonary Function Abnormalities in Hyaline Membrane Disease and Bronchopulmonary Dysplasia

I. Introduction

II. Clinical Evaluation of Pulmonary Function

III. Direct Assessment of Pulmonary Function

IV. Bronchopulmonary Dysplasia: Long-Term Pulmonary Function Sequel of HMD


6 Therapy of Hyaline Membrane Disease

I. Introduction

II. Supportive Care

III. Respiratory Management

IV. Maintenance and Recovery Phase

V. Perspective


7 Long-Term Consequences of Hyaline Membrane Disease

I. Introduction to Follow-Up Studies

II. General Observations

III. Neurologic Sequel

IV. Pulmonary Status of Children Surviving HMD

V. Summary and Conclusions


II Prevention of Hyaline Membrane Disease

8 Introduction to the Preventative Approach in Perinatal Care

I. Introduction

II. Need for Prevention of Hyaline Membrane Disease

III. Investigation of the Preventative Approach in Perinatology


9 Amniocentesis

I. Introduction

II. Indications

III. Technique

IV. Risks

V. Technical Complications

VI. Ultrasound


10 Prenatal Assessment of Fetal Lung Maturation: A Critical Review of Amniotic Fluid Phospholipid Tests

I. Introduction

II. Methodology

III. Clinical Interpretation

IV. Summary and Recommendations


11 Hormonal Aspects of Fetal Lung Development

I. Introduction

II. Effects of Administered Hormones

III. Physiologic Role of Endogenous Hormones

IV. Hormone Binding in Lung


12 The New Zealand Study of Antepartum Glucocorticoid Treatment

I. Introduction

II. Design

III. Findings

IV. Adverse Effects

V. Conclusions

VI. Implications


13 Design and Organization of a Multicenter Clinical Trial for the Study of Corticosteroid Effects on Human Lung Development

I. Background

II. Initiation and Conduct of the Study

III. Quality Control

IV. Summary of Advantages and Disadvantages of the Multicenter Approach


14 The NIH Multicenter Study and Miscellaneous Clinical Trials of Antenatal Corticosteroid Administration

I. Introduction and Objectives

II. Clinical Trials Using Antepartum Corticosteroids

III. The NIH Collaborative Study

IV. Summary


15 Current Recommendations for Use of Prenatal Corticosteroids Based on Assessment of the Risk-Benefit Relationship




No. of pages:
© Academic Press 1982
1st January 1982
Academic Press
eBook ISBN:

About the Editor

Philip M Farrell

Affiliations and Expertise

Robert Turell Professor in Medical Leadership Dean, University of Wisconsin Medical School Vice Chancellor for Medical Affairs

Ratings and Reviews