Neonatal Malignant Disorders, An Issue of Clinics in Perinatology

1st Edition, Volume 48-1 - February 15, 2021
Editor: Daniel S. Wechsler
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 7 6 1 6 6 - 6
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 7 6 1 6 7 - 3

In collaboration with Consulting Editor, Dr. Lucky Jain, Guest Editor Dr. Daniel Wechsler has assembled expert authors to provide a current update on the diagnosis and treatment of… Read more

Neonatal Malignant Disorders, An Issue of Clinics in Perinatology

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In collaboration with Consulting Editor, Dr. Lucky Jain, Guest Editor Dr. Daniel Wechsler has assembled expert authors to provide a current update on the diagnosis and treatment of neonatal malignant disorders. Articles are specifically devoted to the following topics: Genetic Predisposition and Neonatal Cancer; Infant Leukemias; Neonatal Malignant Disorders: Brain Tumors; Retinoblastoma; Neonatal Malignant Disorders: Kidney Tumors; Neonatal Malignant Disorders: Liver Tumors; Neuroblastoma; Neonatal Malignant Disorders: Sarcoma; Neonatal Malignant Disorders: Germ Cell Tumors; Neonatal Histiocytoses; Lymphatic Malformations; and Long-Term Outcomes in Neonatal Cancer Survivors. Readers will come away with the information they need to improve outcomes in infants with neonatal malignant disorders.

Cover image
Title page
Table of Contents
Copyright
Contributors
CME Accreditation Page
Forthcoming Issues
Foreword
Preface
Cancer Predisposition in Neonates and Infants: Recognition, Tumor Types, and Surveillance
Key points
Introduction
Neuroblastoma
Retinoblastoma
Adrenocortical carcinoma
Rhabdoid tumor
Pleuropulmonary blastoma
Medullary thyroid carcinoma
Hepatoblastoma
Wilms tumor
Hematologic malignancies
Genetic testing in neonates
Preconception and prenatal testing
Summary
Neonatal Leukemia
Key points
Definitions and scope
Infant leukemia
Juvenile myelomonocytic leukemia
Transient abnormal myelopoiesis
Summary
Neonatal Central Nervous System Tumors
Key points
Introduction
Prenatal diagnosis and imaging
Types of neonatal brain tumors
Ethical challenges in neonatal brain tumor management
Genetic predisposition
Summary
Neonatal Retinoblastoma
Key points
Introduction
Clinical findings
Differential diagnosis
Diagnostic modalities
Disease classification
Treatment options
Genetics of retinoblastoma
Long-term recommendations
Summary points
Neonatal Renal Tumors
Key points
Introduction
Congenital mesoblastic nephroma
Wilms tumor
Malignant rhabdoid tumor
Clear cell sarcoma
Summary
Clinics care points
Neonatal Liver Tumors
Key points
Introduction
Malignant lesions
Benign lesions
Summary
Neonatal Neuroblastoma
Key points
Introduction
Pathology
Clinical presentation
Neuroblastoma screening
Workup
Risk stratification
Treatment
Summary
Advances in the Diagnosis and Management of Neonatal Sarcomas
Introduction
Epidemiology
Diagnostic considerations
Advances in the management of benign soft tissue tumors
Desmoid-type fibromatosis
Advances in the management of malignant neonatal sarcomas
Extrarenal rhabdoid tumors
Summary
Recent advances and best practices
Conflicts of interest
Ethical statement
Neonatal Malignant Disorders: Germ Cell Tumors
Key points
Introduction
Pathogenesis
Molecular genetics
Epidemiology
Risk factors
Clinical presentation
Histology
Serum tumor markers
Staging and revised risk stratification
Surgical management
Chemotherapy for malignant germ cell tumors
Summary
Clinics care points
Histiocytic Diseases of Neonates: Langerhans Cell Histiocytosis, Rosai-Dorfman Disease, and Juvenile Xanthogranuloma
Key points
Langerhans cell histiocytosis
Rosai-Dorfman disease
Juvenile xanthogranuloma
Clinical care points
Summary
Neonatal Vascular Tumors
Key points
Introduction
Infantile hemangioma
Congenital hemangioma
Tufted angioma and kaposiform hemangioendothelioma
Angiosarcoma
Summary
Late Effects in Survivors of Neonatal Cancer
Key points
Introduction
Late effects
Treatment exposures
Discussion
Summary
Clinical care points