Natural Toxins

Natural Toxins

Proceedings of the 6th International Symposium on Animal, Plant and Microbial Toxins, Uppsala, August 1979

1st Edition - January 1, 1980

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  • Editors: D. Eaker, T. Wadström
  • eBook ISBN: 9781483146560

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Natural Toxins presents the proceedings of the 6th International Symposium on Animal, Plant and Microbial Toxins, held in Uppsala, Sweden on August 1979. This book presents the methods for detection, diagnosis, treatment, and prevention of diseases that natural toxins cause. Organized into 17 parts encompassing 84 chapters, this compilation of papers begins with an overview of the embryonic development, structure, and function of the compound oral glands of venomous and non-venomous snakes in comparison with other exocrine glands. This text then examines the occupational hazards of snakebites in both agriculture and fishing in the Asian areas. Other chapters consider the toxicity and immunological relationships among venoms of several Agkistrodon species. This book discusses as well the characterization of cytotoxins and their mechanisms of action upon model lipid and cell membrane systems. The final chapter deals with neurotoxins as tools for the characterization of molecular components involved in nerve impulse propagation. This book is a valuable resource for biochemists, toxicologists, and pharmacologists.

Table of Contents

  • Preface

    Plenary Lectures

    Venom Glands, Venom Synthesis, Venom Secretion and Evolution

    Pharmacology of Venoms

    Pathophysiology of Envenomation

    Studies on snakebites in the Asian areas

    Crotalid Venom Shock: Mechanism and Treatment

    Renal Diseases in Snakebite

    Ultrastructural Changes in the Lungs, Kidneys and Erythrocytes after Naja Nigricollis Basic Phospholipase Administration

    Signs, Symptoms and Treatment of Severe Scorpion Poisoning in Children

    Histopathology and Physiological Action of Venom from the Brown Recluse Spider, Loxosceles reclusa

    Epidemic of Stings by the Jellyfish Pelagia Noctiluca in the Adriatic

    Venom Toxins and the Immune System

    Study on Immunological Relationships among Venoms of the Asiatic Agkistrodon

    Antigenicity-Determining Residues of Erabutoxin b

    Antisera Against Weever and Scorpionfish Venoms: A Preliminary Report

    Substances Affecting Blood Coagulation abd Fibrinolysis

    Snake Venom Proteases Affecting Blood Coagulation and Fibrinolysis

    Bacterial Activators of Prothrombin

    Classification of Phospholipases A2 Based upon their Anticoagulant Activity and Penetration Ability into Phospholipid Monolayers

    Interference of Endotoxin with Blood Coagulation

    Bacterial Infection and Disseminated Intravascular Coagulation

    Cytolytic Toxins

    Cytotoxins of Some Marine Invertebrates

    Cytolytic Toxins of Basidiomycetes

    Melittin: Structure and Activity

    Liposomes as Models for the Study of Cytolytic Toxins

    Activation of Self-Destruction as a Mechanism of Action for Cytolytic Toxins

    Mechanisms of Action of Cytolytic Toxins on Human Fibroblasts

    Phospholipases and Cell Membranes

    Hemolytic Effects of Snake Venoms

    The Actions of Bacterial Phospholipases C on Plasma Membrane

    Differential Phospholipid Hydrolysis by Phospholipase C in Sarcolemma of Muscles with Calcium or Sodium Generated Action Potentials

    Cooperative Action of Purified Bactericidal/Permeability Increasing Protein and Phospholipase A2 from Rabbit Polymorphonuclear Leukocytes


    Escherichia Coli Heat Labile Enterotoxin: DNA-Directed in Vitro Synthesis and Structure

    Pathogenesis of Vibrio Parahaemolyticus

    Purification of Aeromonas Hydrophila Enterotoxin and its Mode of Action in Experimental Model

    Lipid A and Endotoxin

    Differences in Lipopolysaccharide-Induced Prostaglandin-Release and Phagocytic Activity of Peritoneal Macrophages from LPS-Hyperreactive and Tolerant Mice

    LPS Regulation of the Immune Response: Cellular and Molecular Basis of Adjuvanticity and the Role of Suppressor T Cells on Host Responses

    The Role of Lipid A and Lipid A-Associated Protein in Cell Degranulation Mechanisms

    Platelet-Endotoxin Interactions in Normal and Resistant Animals

    Cell Growth and Candidacidal Activity of Mouse Peritoneal Macrophages in Response to Glucocorticoid, Choleragen and Lipopolysaccharide

    The Effect of Endotoxic Substances on Granulopoiesis

    Studies on Lipid A Immunity in Animals and Infected Children

    Tumor Regression Caused by Endotoxins Combined with Trehalose Dimycolate

    Bacterial Lipopolysaccharides Induce Changes in Lipoprotein and Acute Phase Proteins in C3H/HeJ 'Non-Responder' Mice

    Interaction of Lipopolysaccharides with Plasma High-Density Lipoprotein in Rats

    Effects of Bacterial Endotoxin on Cerebrospinal Proteins in Guinea Pigs

    Structure and Toxicity of Lipid A from Vibrio cholerae

    Escherichia Coli Endotoxin and Enterotoxin Implication on Pharmacokinetics of Drugs

    Edema and Purpura-Producing Toxins

    Studies on Toxicity and Immunogenicity of Staphylococcal Exfoliatins A and B

    Thermal Analysis and Nuclear Magnetic Resonance as Probes for the Study of Edema Induced in Rat Skin by Some Bacterial Toxins

    Novel Bacterial Toxins

    Clostridium Difficile and Pseudomembranous Colitis in Humans

    Studies on the Clostridial Toxin Associated with Antibiotic-Induced Pseudomembranous Colitis

    Interaction of Clostridium Difficile Toxin with Human Fibroblasts in vitro

    The Effect of Pseudomonas Aeruginosa Exotoxin A on Antibody-Forming Mouse Spleen Cells

    Toxins with Intracellular Targets

    Investigations into the Relationships Between Structure and Function of Diphtheria Toxin Fragment B

    Ricin Inhibition of Fungi Mitochondrial and Chloroplastic Protein Synthesis

    Inhibition of Hepatoma Tissue Culture Cell Growth and of Cellular Protein, DNA and RNA Synthesis by Ricin and Two of its Tryptic Peptides

    Action of Ricin on Steroid-Mediated Induction of Tyrosine Aminotransferase in Hepatoma Tissue Culture Cells

    Effect of Cholera Toxin on Ricin Activity

    Receptor-Mediated Binding and Internalization of Pseudomonas Exotoxin A and Diphtheria Exotoxin by Mammalian Cells

    Shigella Shigae Cytotoxin. Isolation, Characterization and Interaction with Cells

    Structure and Function of Polypeptide Neurotoxins

    Chemical Structure, Biological and Pharmacological Activities of Apamin and their Relations

    Structure-Function Relationships in Cerebratulus Toxin B-IV

    Conformation of Pardaxin, the Purified Polypeptide from the Toxic Secretion of the Flatfish Pardachirus Marmoratus Studied by Laser Raman Spectroscopy and Circular Dichroism

    Structure-Function Relationships in Postsynaptic Snake Neurotoxins

    Three-Dimensional Structure of α-Cobratoxin

    The Structure of the Reactive Site in Elapidae Neurotoxins

    Spin and Fluorescence Labelled Neurotoxin II. Conformational Studies and Interaction of the Toxin with the Acetylcholine Receptor

    Muscarinic Acetylcholine Receptor

    Venom Toxins Affecting Neurotransmitter Release

    Pharmacology of Presynaptic Neurotoxins from Snake Venoms

    Interaction of 3-Bungarotoxin with Synapses in the Mammalian Central Nervous System

    Biological Activities of Crotoxin and Amino Acid Sequence of Crotoxin B

    Muscle Necrosis Induced by Some Presynaptically Active Neurotoxins

    Black Widow Spider Toxin: Effect on Catecholamines Release and Cation Permeability in a Neurosecretory Cell Line (PC12)

    Botulinum and Tetanus Toxins

    Botulism: Clinical and Electrical Observations

    Botulinum A and Tetanus Toxin: Effects on Neurotransmission to Striated and Smooth Muscles

    Studies on the Prophylaxis and Treatment of Botulism

    Effect of Tetanus Toxin on the Excitatory Transmission of the Motoneurone and other Synapses in the Motor System

    New Trends in the Study of the Pathogenesis of Tetanus Symptoms in the Motor System

    Novel Toxins and Toxic Effects

    Structure-Activity Studies on Bee Venom Polypeptides

    Isolation, Purification and some Properties of Suberitine, the Toxic Protein from the Marine Sponge, Suberites Domuncula

    Toxins Selective to Insects Derived from Scorpion Venoms

    Toxic Effects of Cycasin, the Glycoside of Cycad Plant, upon Several Biological Species

    Enzymatic Hydrolysis of Amygdalin by Fecal Samples and some Foods


    Toxicological Evaluation of Trichothecene Mycotoxins

    Ochratoxins: Occurrence, Biological Effects and Causal Role in Diseases

    Metabolism and Mode of Action of Aflatoxin in Relation to the Etiology of Liver Diseases in Man and Farm Animals

    Effects of Mycotoxins on Immunity and Resistance of Animals

    Additional Paper

    Neurotoxins as Tools for Biochemical Characterization of Ion Channels

    Author Index

    Keyword Index

Product details

  • No. of pages: 732
  • Language: English
  • Copyright: © Pergamon 1980
  • Published: January 1, 1980
  • Imprint: Pergamon
  • eBook ISBN: 9781483146560

About the Editors

D. Eaker

T. Wadström

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