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Natural Resistance Systems Against Foreign Cells, Tumors, and Microbes - 1st Edition - ISBN: 9780121997359, 9780323156493

Natural Resistance Systems Against Foreign Cells, Tumors, and Microbes

1st Edition

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Editor: Gustavo Cudkowicz
eBook ISBN: 9780323156493
Imprint: Academic Press
Published Date: 1st January 1978
Page Count: 312
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Natural Resistance Systems Against Foreign Cells, Tumors, and Microbes presents the proceedings of an international conference held at Timber Cove Inn Jenner, California on October 18-22, 1976. It deals with the resistance to microorganisms and tumors, the dual problems of basic immunology, and the clinical aspects of immune reconstitution. It focuses on the identification and characterization of host defense systems, endowed with specificity, yet non-induced, non-adaptive, and non-thymus dependent. Divided into 12 chapters, the book initially discusses natural resistance to foreign hematopoietic and leukemic grafts. It goes on, examining the critical issues in clinical bone marrow transplantation and graft-versus-host (GVH) disease as a consequence of bone marrow grafting. Chapters 5 to 8 discuss the role of macrophage, Hh genes, major histocompatibility complex, and natural killer cell systems in natural resistance to normal and malignant cells. The final chapters cover the mechanism of cell’s natural resistance to intracellular bacteria, genetic resistance to leukomogenesis, and manipulations to control the allograft response and GVH disease. This book is an invaluable resource for those interested in basic immunology, immune reconstitution, natural resistance phenomena, and GHV disease.

Table of Contents




Natural Resistance to Foreign Hemopoietic and Leukemia Grafts

Thymic Functions and Resistance to Foreign Hemopoietic Grafts

Critical Issues in Clinical Bone Marrow Transplantation

Graft-versus-Host Disease as a Consequence of Bone Marrow Grafting

Macrophage Heterogeneity: Role in Hemopoiesis and Cytotoxicity for Normal and Neoplastic Targets

In Vitro Models of Hh-Mediated Resistance and MHC Incompatibility

MCH-Restricted Cellular Immunity: Altered Self and Minor Alloantigens

NK Cell Systems as Effectors of Resistance to Normal and Malignant Hemopoietic Cells

Distinctive Mechanisms in Naturally Occurring Genetic Resistance to Leukemogenesis

Mechanism of Natural Resistance to Intracellular Bacteria. Manipulations Weakening Host Resistance

Manipulations to Control the Allograft Response and GVH Disease

Conference Overview and Assessment


Author Index

Subject Index


No. of pages:
© Academic Press 1978
1st January 1978
Academic Press
eBook ISBN:

About the Editor

Gustavo Cudkowicz

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