Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids - 1st Edition - ISBN: 9780128022153, 9780128025277

Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids, Volume 36

1st Edition

Serial Volume Editors: Fuyuhiko Tamanoi S. Bathaie
eBook ISBN: 9780128025277
Hardcover ISBN: 9780128022153
Imprint: Academic Press
Published Date: 3rd December 2014
Page Count: 282
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Table of Contents

  • Preface
  • Chapter One: Introduction
    • Abstract
  • Chapter Two: Perillyl Alcohol (Monoterpene Alcohol), Limonene
    • Abstract
    • 1 Introduction
    • 2 Perillyl Alcohol
    • 3 Limonene
    • 4 Concluding Remarks
    • Acknowledgment
  • Chapter Three: Ganoderic Acid and Lucidenic Acid (Triterpenoid)
    • Abstract
    • 1 Introduction
    • 2 Lucidenic Acids and Ganoderic Acids from Ganoderma Species
    • 3 Biological Functions of Lucidenic Acids and Ganoderic Acids
    • 4 Pharmacokinetics of Ganoderic Acids
    • 5 Conclusion
  • Chapter Four: Anticancer Effect and Molecular Targets of Saffron Carotenoids
    • Abstract
    • 1 Introduction
    • 2 Anticancer Effect of Saffron and Its Carotenoids
    • 3 Comparing the Efficacy of Crocetin, Crocin, and Other Components
    • 4 Liposome Formulation of Saffron Compounds
    • 5 Effect of Crocetin and Crocin on Macromolecule Synthesis and Structure
    • 6 Effects on Cell Cycle, Apoptosis, and Signaling Pathways
    • 7 Role of Saffron Components on Chemoprevention
    • 8 Molecular Mechanisms Involved in the Protective Effect of Saffron Components against Various Damages in Different Tissues
    • 9 Antioxidant and Anti-inflammatory Effects of Saffron
    • 10 Safety
    • 11 Other Mechanisms
    • 12 Conclusions
  • Chapter Five: Zerumbone from Ginger (Monoterpenoid)
    • Abstract
    • 1 Introduction
    • 2 Characteristic Feature
    • 3 Target Pathways by Zerumbone
    • 4 Nuclear Factor-Kappa B
    • 5 Future Perspectives
  • Chapter Six: Research Progress on Natural Triterpenoid Saponins in the Chemoprevention and Chemotherapy of Cancer
    • Abstract
    • 1 Introduction
    • 2 Triterpenoid Saponins in the Prevention and Therapy of Cancers
    • 3 Anticancer Properties and Molecular Mechanisms of Triterpenoid Saponins
    • 4 Structure–Activity Relationships of Anticancer Activities of Triterpenoid Saponins
    • 5 Clinical Studies
    • 6 Summary and Perspectives
  • Chapter Seven: Neem Limonoids as Anticancer Agents: Modulation of Cancer Hallmarks and Oncogenic Signaling
    • Abstract
    • 1 Introduction
    • 2 Cytotoxicity of Neem Limonoids
    • 3 Neem Limonoids and Hallmarks of Cancer
    • 4 Oncogenic Signaling
    • 5 Conclusions and Future Perspectives
  • Chapter Eight: Curcumin: A Potent Modulator of Multiple Enzymes in Multiple Cancers
    • Abstract
    • 1 Introduction
    • 2 Structure–Activity Relationship of Curcumin
    • 3 Curcumin Binds and Modulates Multiple Enzymes
    • 4 Curcumin Binds and Modulates PKs
    • 5 Curcumin Directly Binds and Modulates Protein Reductases
    • 6 Others
    • 7 Curcumin Clinical Trials in Cancer
    • 8 Future Perspectives
    • Acknowledgment
  • Chapter Nine: Molecular Targets of Honokiol: A Promising Phytochemical for Effective Cancer Management
    • Abstract
    • 1 Introduction
    • 2 Honokiol: Structure–Activity Relationship
    • 3 Anticancer Effect of Honokiol
    • 4 Molecular Targets of Honokiol
    • 5 Pharmacokinetics of Honokiol
    • 6 Conclusion and Future Outlook
    • Acknowledgments
  • Chapter Ten: Effects of Tea Catechins on Cancer Signaling Pathways
    • Abstract
    • 1 Introduction
    • 2 Chemistry, Bioavailability, and Biotransformation of Tea Catechins
    • 3 Inhibition of Tumorigenesis by Tea Catechins in Animal Models and Possible Mechanisms
    • 4 Biochemical Activities of Tea Catechins
    • 5 Modulating Signaling Pathways and Cell Functions
    • 6 Issues in Extrapopulating Studies In Vitro to Situations In Vivo
    • 7 Concluding Remarks
    • Acknowledgments
  • Author Index
  • Subject Index


Natural compounds from a variety of natural resources including plants have emerged as important source of anticancer drug development. This special issue will highlight the significant advance in elucidating mechanisms of action of these natural compounds, focusing especially on isoprenoids and polyphenols/flavonoids.

Key Features

  • Informs and updates on all the latest developments in the field
  • Contributions from leading authorities and industry experts


Researchers in biochemistry, molecular and cell biology, pharmacology, and cancer


No. of pages:
© Academic Press 2014
Academic Press
eBook ISBN:
Hardcover ISBN:

Ratings and Reviews

About the Serial Volume Editors

Fuyuhiko Tamanoi Serial Volume Editor

Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997. Since 1996, he has been a Director of Signal Transduction Program Area at Jonsson Comprehensive Cancer Center. Dr. Tamanoi earned his B.S. and M.S. in Biochemistry at the University of Tokyo. He received PhD in Molecular Biology at Nagoya University in 1977. He was a postdoctoral fellow at Harvard Medical School, where he worked on bacteriophage DNA replication. From 1980 to 1985, he was a senior staff investigator at Cold Spring Harbor Laboratory, where he worked on adenovirus DNA replication. From 1985 to 1993, he was an Assistant Professor and then Associate Professor at the University of Chicago, where he initiated studies on lipid modification of the Ras family proteins. His laboratory research centers on signal transduction and signal transduction inhibitors. He is currently exploring ways to deliver signal transduction inhibitors using nanoparticles.

Affiliations and Expertise

Professor and Vice Chair, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles and Director, Signal Transduction Program Area, Jonsson Comprehensive Cancer Center, USA

S. Bathaie Serial Volume Editor

Affiliations and Expertise

Univeristy of California, Los Angeles, USA