This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The second of 3 volumes covering Natural product biosynthesis by microorganisms and plants.

Key Features

  • This new volume continues the legacy of this premier serial
  • Contains quality chapters authored by leaders in the field
  • The second of 3 volumes it has chapters on such topics as biological chlorination, bromination and iodination, and phylogenetic approaches to natural product structure prediction
  • Readership

    Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

    Table of Contents

    1. In vivo production of thiopeptide variants
      Feifei Zhang and Wendy L. Kelly
    2. Microviridin biosynthesis
      Thomas K. Hemscheidt
    3. Cyclotide isolation and characterization
      David J. Craik, Sonia Troeira Henriques, Joshua S. Mylne and Conan K. Wang
    4. Ribosomally-encoded cyclic peptide toxins from mushrooms
      Jonathan Walton, Hong Luo, and Heather Hallen-Adams
    5. The Pictet-Spengler mechanism involved in the biosynthesis of tetrahydroisoquinoline antitumor antibiotics: novel function for a non-ribosomal peptide synthetase
      Kento Koketsu, Atsushi Minami, Kenji Watanabe, Hiroki Oguri and Hideaki Oikawa
    6. Discovery and biosynthesis of phosphonate and phosphinate natural products
      Spencer C. Peck, Jiangtao Gao, and Wilfred A. van der Donk
    7. RlmN and AtsB as models for the overproduction and characterization of radical SAM proteins
      Nicholas D. Lanz, Tyler, L. Grove, Camelia Gogonea, Carsten Krebs, and Squire J. Booker
    8. Fe(II)-dependent, uridine-5’-monophosphate α-ketoglutarate dioxygenases in the synthesis of 5’-modified nucleosides
      Zhaoyong Yang, Jason Unrine, Koichi Nonaka, and Steven G. Van Lanen
    9. Heme-dependent Tailoring Enzymes in Natural Product Biosynthesis: Spectroscopic Characterisation of the L-tryptophan-nitrating Cytochrome P450 TxtE
      S. M. Barry and Greg Challis
    10. Oxidative Tailoring Reactions Catalysed by Non-heme Iron-dependent Enzymes: Streptorubin B Biosynthesis as an Example
      Paulina K. Sydor and Greg Challis
    11. The rare fluorinated natural products and biotechnological prospects for fluorine enzymology
      K. K. Jason Chan and David O’Hagan


    No. of pages:
    © 2012
    Academic Press
    Print ISBN:
    Electronic ISBN: