Natural, Metal, Fiber, and Macromolecular Carcinogens - 1st Edition - ISBN: 9780120593538, 9781483216027

Natural, Metal, Fiber, and Macromolecular Carcinogens

1st Edition

Structural Bases and Biological Mechanisms

Authors: Yin-Tak Woo David Y. Lai Joseph C. Arcos
eBook ISBN: 9781483216027
Imprint: Academic Press
Published Date: 28th July 1988
Page Count: 895
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Description

Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, Volume IIIC: Natural, Metal, Fiber, and Macromolecular Carcinogens covers structure-carcinogenicity relationships of carcinogenic mycotoxins, carcinogenic substances generated by plants, carcinogenic metals and metalloids, and foreign-body carcinogens.
The book discusses the metabolism and mechanism of carcinogenic action, physicochemical properties, other biological activities (principally mutagenicity and teratogenicity), modification of carcinogenic activity, formation and environmental significance. The text also describes the carcinogenic water-soluble high polymers and explores the intriguing problems of the carcinogenic effect of osmotic imbalance in tissue microenvironment, as well as of spontaneous malignant transformation occurring in cell cultures in vitro. Studies on tumor induction and carcinogenesis modification by nonviral nucleic acids, by nucleases, proteases, histones, and by antigenic stimulation as well as by antibodies are also considered.
The book further tackles tumor-released factors as possible modifiers of carcinogenesis. The text will prove invaluable to chemists and people involved in cancer research.

Table of Contents


General Plan

Preface

Acknowledgments

Part III (Continued) Structure-Activity Relationships of Chemical Carcinogens. Effect of Reactivity, Molecular Geometry, and Metabolism on Carcinogenic Activity

5 . Structure-Activity Relationships

5.3 Naturally Occurring Carcinogens

5.4 Inorganic Carcinogens: Metals, Metalloids, and Other Inorganic Chemicals

5.5 Foreign-Body Carcinogens: Fibers, Silica, and Implants

5.6 Special Topics

5.7 Nonviral Biological Carcinogens and Modifiers of Carcinogenesis

Appendix I: Novel Types of Carcinogens and Updating "News" Items

A. Novel Types of Carcinogens

B. Updating "News" Items

References to Appendix I

Special Reviews Pertaining to Appendix I

Proof-stage Notes to Appendix I

Appendix II: Nitroarenes

Introduction

Occurrence and Formation

Genotoxicity and Mutagenicity in Bacteria

Basis for the Mutagenicity of Nitroarenes in Bacteria

Genotoxicity and Mutagenicity in Mammalian Cells

Metabolism by Mammalian Cells and by Cell-Free Extracts

In Vivo Genotoxicity

Oncogenic Transformation

Carcinogenicity in Animals

Metabolism and Biodisposition in Whole Animals

Nitroarene-Induced Microsomal Monooxygenases

Competition of Nitroarenes with TCDD for Binding Sites

References to Appendix II

Source Book for Appendix II

Appendix III: Mutagens/Carcinogens in Pyrolysates of Amino Acids and Proteins and in Cooked Foods: Heterocyclic Aromatic Amines

Historical Background

Physicochemical Properties

Synthesis

Mutagenicity

Carcinogenicity

Other Biological Properties

Metabolism and Mechanism of Carcinogenesis

Quantification and Human Risk

Future Prospects

References to Appendix III

Source Books and Major Reviews for Appendix III

Appendix IV: Decontamination and Destruction of Chemical Carcinogens

Introduction

Waste Disposal

Handling Considerations

Destruction Procedures

Conclusion

References to Appendix IV

Appendix V: General Principles for the Prediction of Potential Carcinogenic Activity of Chemical Compounds

Introduction

Criteria for Suspecting a Chemical Agent of Having Carcinogenic Activity

Overview of Interactions Determining Tumor Outcome in the Carcinogenic Process

Physical and Chemical Properties Modulating the Carcinogenic Potential of a Chemical Compound

Structural Criteria

Functional Criteria

Possible Use of Artificial Intelligence in the Prediction of Suspected Carcinogens

References to Appendix V

Special Reviews Pertaining to Appendix V

Appendix VI: Evaluation of Scientific Uncertainty: Semantic-Probabilistic View of Narrative Expressions—An Aid to Hazard Assessment

Introduction

Assessing Chemical Hazard

Expressing Chemical Hazard Potential

Assessing the Use of Narrative Probability Expressions

Analysis of the Survey Results

Standardization Scheme

Best Estimate versus Uncertainty: Separating the Assessment into Two Segments

Conclusions

References to Appendix VI

Index

Cumulative Chemicals Index to Volumes IIA-IIIC




Details

No. of pages:
895
Copyright:
© Academic Press 1988
Published:
Imprint:
Academic Press
eBook ISBN:
9781483216027

About the Author

Yin-Tak Woo

David Y. Lai

Joseph C. Arcos