Natural, Metal, Fiber, and Macromolecular Carcinogens

Natural, Metal, Fiber, and Macromolecular Carcinogens

Structural Bases and Biological Mechanisms

1st Edition - January 1, 1988

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  • Authors: Yin-Tak Woo, David Y. Lai, Joseph C. Arcos
  • eBook ISBN: 9781483216027

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Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, Volume IIIC: Natural, Metal, Fiber, and Macromolecular Carcinogens covers structure-carcinogenicity relationships of carcinogenic mycotoxins, carcinogenic substances generated by plants, carcinogenic metals and metalloids, and foreign-body carcinogens. The book discusses the metabolism and mechanism of carcinogenic action, physicochemical properties, other biological activities (principally mutagenicity and teratogenicity), modification of carcinogenic activity, formation and environmental significance. The text also describes the carcinogenic water-soluble high polymers and explores the intriguing problems of the carcinogenic effect of osmotic imbalance in tissue microenvironment, as well as of spontaneous malignant transformation occurring in cell cultures in vitro. Studies on tumor induction and carcinogenesis modification by nonviral nucleic acids, by nucleases, proteases, histones, and by antigenic stimulation as well as by antibodies are also considered. The book further tackles tumor-released factors as possible modifiers of carcinogenesis. The text will prove invaluable to chemists and people involved in cancer research.

Table of Contents

  • General Plan



    Part III (Continued) Structure-Activity Relationships of Chemical Carcinogens. Effect of Reactivity, Molecular Geometry, and Metabolism on Carcinogenic Activity

    5 . Structure-Activity Relationships

    5.3 Naturally Occurring Carcinogens

    5.4 Inorganic Carcinogens: Metals, Metalloids, and Other Inorganic Chemicals

    5.5 Foreign-Body Carcinogens: Fibers, Silica, and Implants

    5.6 Special Topics

    5.7 Nonviral Biological Carcinogens and Modifiers of Carcinogenesis

    Appendix I: Novel Types of Carcinogens and Updating "News" Items

    A. Novel Types of Carcinogens

    B. Updating "News" Items

    References to Appendix I

    Special Reviews Pertaining to Appendix I

    Proof-stage Notes to Appendix I

    Appendix II: Nitroarenes


    Occurrence and Formation

    Genotoxicity and Mutagenicity in Bacteria

    Basis for the Mutagenicity of Nitroarenes in Bacteria

    Genotoxicity and Mutagenicity in Mammalian Cells

    Metabolism by Mammalian Cells and by Cell-Free Extracts

    In Vivo Genotoxicity

    Oncogenic Transformation

    Carcinogenicity in Animals

    Metabolism and Biodisposition in Whole Animals

    Nitroarene-Induced Microsomal Monooxygenases

    Competition of Nitroarenes with TCDD for Binding Sites

    References to Appendix II

    Source Book for Appendix II

    Appendix III: Mutagens/Carcinogens in Pyrolysates of Amino Acids and Proteins and in Cooked Foods: Heterocyclic Aromatic Amines

    Historical Background

    Physicochemical Properties




    Other Biological Properties

    Metabolism and Mechanism of Carcinogenesis

    Quantification and Human Risk

    Future Prospects

    References to Appendix III

    Source Books and Major Reviews for Appendix III

    Appendix IV: Decontamination and Destruction of Chemical Carcinogens


    Waste Disposal

    Handling Considerations

    Destruction Procedures


    References to Appendix IV

    Appendix V: General Principles for the Prediction of Potential Carcinogenic Activity of Chemical Compounds


    Criteria for Suspecting a Chemical Agent of Having Carcinogenic Activity

    Overview of Interactions Determining Tumor Outcome in the Carcinogenic Process

    Physical and Chemical Properties Modulating the Carcinogenic Potential of a Chemical Compound

    Structural Criteria

    Functional Criteria

    Possible Use of Artificial Intelligence in the Prediction of Suspected Carcinogens

    References to Appendix V

    Special Reviews Pertaining to Appendix V

    Appendix VI: Evaluation of Scientific Uncertainty: Semantic-Probabilistic View of Narrative Expressions—An Aid to Hazard Assessment


    Assessing Chemical Hazard

    Expressing Chemical Hazard Potential

    Assessing the Use of Narrative Probability Expressions

    Analysis of the Survey Results

    Standardization Scheme

    Best Estimate versus Uncertainty: Separating the Assessment into Two Segments


    References to Appendix VI


    Cumulative Chemicals Index to Volumes IIA-IIIC

Product details

  • No. of pages: 895
  • Language: English
  • Copyright: © Academic Press 1988
  • Published: January 1, 1988
  • Imprint: Academic Press
  • eBook ISBN: 9781483216027

About the Authors

Yin-Tak Woo

David Y. Lai

Joseph C. Arcos

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