Natural Cell-Mediated Immunity Against Tumors

Natural Cell-Mediated Immunity Against Tumors

1st Edition - January 1, 1980

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  • Editor: Ronald Herberman
  • eBook ISBN: 9780323141734

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Description

Natural Cell-Mediated Immunity Against Tumors aims to be the first book to provide a comprehensive discussion on natural cell-mediated immunity against tumors. This book is mostly a collection of different research contributed by leading laboratories. It also presents a better perspective of how natural mechanisms fit in with and relate to the traditional and more extensively studied components of the immune system. The book starts off with an overview of the contents of the volume – the historical development of the advances in the field of research and the status of knowledge in the subject area. Divided into four major sections, the book consists of a total of 98 chapters. The sections discuss the natural killer cells and related cells and the natural lymphokine production. This book also explains the natural macrophage and granulocyte cytotoxicity. The book will be a helpful reference for students, professionals, and researchers in biology, immunology, biochemistry, microbiology, and other related fields.

Table of Contents


  • Participants

    Preface

    Section I Natural Killer (NK) Cells and Related Cells

    A Characteristics of NK and Related Cells

    Characteristics of NK and Related Cells

    Alloantisera Selectively Reactive with NK Cells: Characterization and Use in Defining NK Cell Classes

    Asialo GMl and Thy 1 as Cell Surface Markers of Murine NK Cells

    Characteristics of Natural Cytostatic Effector Cells

    Characterization of the NK Cell in Man and Rodents

    Characteristics of Murine NK Cells in Relation to T Lymphocytes and K Cells

    Characteristics of NK Cells

    Antigenic Phenotype of Mouse Natural Killer Cells

    Natural Cytotoxicity of Macrophage Precursor Cells and of Mature MacrophageS

    Centrifugal Elutriation Allows Enrichment of Natural Killing and Separates Xenogeneic and Allogeneic Reactivity

    Effects of Alloantisera on Murine K and NK Cell Activity

    Characteristics of Human Natural Killer Cells

    Phenotypic Characteristics of NK Cells in the Mouse

    Morphology and Surface Properties of Human NK Cells

    Natural Cytotoxic (NC) Cells against Solid Tumors in Mice: General Characteristics and Comparison to Natural Killer (NK) Cells

    Ontogeny and Other Age-Related Effects of Natural Cytotoxic (NC) Cells in Mice

    Biophysical and Serological Characterization of Murine NK Cells

    Analysis of Recognition Patterns of NK Cells through Use of Varying Combinations of Mouse Strains and Tumor Targets

    FACS Analysis and Enrichment of NK Effector Cells

    B Mechanism of Cytotoxicity by NK Cells and Their Relationship to K Cells

    Summary: Characteristics of NK and Related Cells

    Mechanism of Cytotoxicity by NK Cells and Their Relationship to K Cells

    Quantitation of Human Natural and Antibody-Dependent Cytotoxicity

    The Relationship between Natural and Antibody-Dependent Cell-Mediated Cytotoxicity

    Differential Effects of Immune Complexes on Human Natural and Antibody-Dependent Cell-Mediated Cytotoxicity

    Natural Killing and Antibody-Dependent Cellular Cytotoxicity: Independent Mechanisms Mediated by Overlapping Cell

    Are Spontaneous and Antibody-Dependent Lysis Two Different Mechanisms of Cytotoxicity Mediated by the Same Cell?

    A Comparative Analysis of the NK Cytolytic Mechanism and Regulatory Genes

    Summary: Mechanism of Cytotoxicity by NK Cells and Their Relationship to K Cells

    C1 Immunogenetic Regulation of NK Activity

    Immunogenetics of Natural Immunity

    Augmentation of Natural Killer Cell Activity of Beige Mice by Interferon and Interferon Inducers

    Mutations That Influence Natural Cell-Mediated Cytotoxicity in Rodents

    Genetic Influences Affecting Natural Cytotoxic (NC) Cells in Mice

    Summary: Immunogenetic Regulation of NK Activity

    C2 Development of NK Activity during in Vitro Culture

    Development of NK Activity during in Vitro Culture

    In Vitro Development of Human NK Cells: Characteristics of Precursors and Effector Cells and Possible Cell Lineage

    MLC-Induced Cytotoxicity against NK-Sensitive Targets

    Summary: Development of NK Activity during in Vitro Culture

    C3 Augmentation of NK Activity

    Interferon and NK Cells in Resistance to Persistently Virus-Infected Cells and Tumors

    Interferon-Independent Activation of Murine Natural Killer Cell Activity

    Enhancement of Human NK Activity by Interferon. In Vivo and in Vitro Studies

    Regulatory Factors in Human Natural and Antibody-Dependent Cell-Mediated Cytotoxicity

    Spontaneous Cell-Mediated Cytotoxicity (SCMC) and Short-Term Mixed Leukocyte Culture (MLC): Role of Soluble Factors and of Cellular Interactions

    Augmentation of Human NK and ADCC by Interferon

    Factors Controlling the Augmentation of Natural Killer Cells

    Characteristics of Augmentation by Interferon of Cell-Mediated Cytotoxicity

    Spontaneous Cell-Mediated Cytotoxicity (SCMC): Enhancement by Interferons and Corynebacterium Parvum-Induced T-Cell Factor(s) Lacking Antiviral Activity

    Modulation of Natural Cytotoxicity in Man by BCG and Fibroblast Interferon

    Regulation of Human Natural Killer Activity by Interferon

    Spontaneous Cell-Mediated Cytotoxicity: Modulation by Interferon

    Activated Natural Killer Cells Induced during the Lymphocytic Choriomeningitis Virus Infection in Mice

    Augmentation of Human Natural Killer Cell Activity by Purified Interferon and Polyribonucleotides

    Summary: Augmentation of NK Activity

    C4 Suppression or Inhibition of NK Activity

    Prostaglandin-Mediated Inhibition of Murine Natural Killer Cell Activity

    C. Parvum-Mediated Suppression of the Phenomenon of Natural Killing and Its Analysis

    Inhibition As Well As Augmentation of Mouse NK Activity by Pyran Copolymer and Adriamycin

    The Effect of 17/3-Estradiol on Natural Killing in the Mouse

    Summary: Suppression or Inhibition of NK Activity

    D Specificity of Cytotoxicity by NK Cells and Nature of Recognition Structures on Effector and Target Cells

    Comparison of Natural Immunity to MTV and Natural Killer Reactivity

    The Use of Lymphoma Cell Variants Differing in Their Susceptibility to NK Cell-Mediated Lysis to Analyse NK Cell- Target Cell Interactions

    Kinetic Analysis of Specificity in Human Natural Cell-Mediated Cytotoxicity

    Human Natural Cell-Mediated Cytotoxicity: A Polyspecific System

    Interaction between NK Cells and Normal Tissue: Definition of a NK-Sensitive Thymocyte Population

    Specificity of NK Cells

    Heterogeneity in Natural Killing

    Are Natural Killer Cells Germ-Line V-Gene-Encoded Prothymocytes Specific for Self and Nonself Histocompatibility Antigens?

    Natural and Activated Lymphocyte Killers which Affect Tumor Cells

    Murine Retrovirus—Specific Natural Killer Cell Activity

    The Specificity of NK Cells at the Level of Target Antigens and Recognition Receptors

    Natural Cytotoxic (NC) Cells against Solid Tumors in Mice: Some Target Cell Characteristics and Blocking of Cytotoxicity by D-Mannose

    Modification of Target Susceptibility to Activated Mouse NK Cells by Interferon and Virus Infections

    Summary: Specificity of Cytotoxicity by NK Cells and Nature of Recognition Structures on Effector and Target Cells

    E NK Aactivity during Carcinogenesis and Tumor Growth and Its Expression within Tumors

    Intratumor NK Reactivity

    Cytotoxicity and Cytostasis Mediated by Splenocytes of Mice Subjected to Chemical Carcinogens and of Mice-Bearing

    NK Cell Activity in the Blood, Tumor-Draining Lymph Nodes, and Primary Tumors of Women with Mammary Carcinoma

    Natural Cell-Mediated Cytotoxicity in Human Tumor Patients

    Systemic and in Situ Natural Killer Activity in Tumor-Bearing Mice and Patients with Cancer

    Natural Killer Cells in Tumor-Bearing Patients

    Natural Cytotoxic (NC) Cells in Tumor-Bearing Mice

    Natural Killers in Human Cancer: Activity of Tumor-Infiltrating and Draining Node Lymphocytes

    Summary: NK Activity during Carcinogenesis and Tumor Growth and Its Expression within Tumors

    F In Vivo Role of NK Cells in Host Defense

    In Vivo Activity of Murine NK Cells

    Analogy between Rejection of Hemopoietic Transplants and Natural Killing

    Role of NK Cells in Rapid in Vivo Clearance of Radiolabeled Tumor Cells

    Summary: In Vivo Role of NK Cells in Host Defense

    G Natural Immunity and Resistance Against Microbial Agents

    Natural Resistance of Mice toward Orthomyxoviruses

    Natural Macrophage Cytotoxicity against Protozoa

    Natural Killer Cell Activity against Virus-Infected Cells

    Summary: Natural Immunity and Resistance against Microbial Agents

    Section II Natural Lymphokine Production

    Interferon Production in Murine Spleen Cell Cultures

    Natural Production of Macrophage-Migration Inhibitory Factor and Human-Leukocyte Inhibitory Factor

    Interferon Production in Lymphocytes Cultured with Tumor-Derived Cells

    Summary: Natural Lymphokine Production

    Section III Natural Macrophage Cytotoxicity

    Regulatory Capacities of Mononuclear Phagocytes with Particular Reference to Natural Immunity against Tumors

    Natural Cytotoxicity on Tumor Cells of Human Monocytes and Macrophages

    Summary: Natural Macrophage Cytotoxicity

    Section IV Natural Granulocyte Cytotoxicity

    The Role of Granulocytes in Host Defense against Tumors

    Summary: Natural Granulocyte Cytotoxicity

    Index




Product details

  • No. of pages: 1344
  • Language: English
  • Copyright: © Academic Press 1980
  • Published: January 1, 1980
  • Imprint: Academic Press
  • eBook ISBN: 9780323141734

About the Editor

Ronald Herberman

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